Gene description for UBA52
Gene name ubiquitin A-52 residue ribosomal protein fusion product 1
Gene symbol UBA52
Other names/aliases CEP52
HUBCEP52
L40
RPL40
Species Homo sapiens
 Database cross references - UBA52
ExoCarta ExoCarta_7311
Vesiclepedia VP_7311
Entrez Gene 7311
HGNC 12458
MIM 191321
UniProt P62987  
 UBA52 identified in sEVs derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 17956143    
Colorectal cancer cells 19837982    
Embryonic kidney cells 36706192    
Embryonic kidney cells 36706192    
Mesenchymal stem cells Unpublished / Not applicable
Neuroblastoma cells 25944692    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for UBA52
Molecular Function
    structural constituent of ribosome GO:0003735 IBA
    structural constituent of ribosome GO:0003735 IDA
    structural constituent of ribosome GO:0003735 NAS
    protein binding GO:0005515 IPI
    protein tag activity GO:0031386 IBA
    ubiquitin protein ligase binding GO:0031625 IBA
Biological Process
    cytoplasmic translation GO:0002181 IC
    cytoplasmic translation GO:0002181 IDA
    cytoplasmic translation GO:0002181 NAS
    translation GO:0006412 NAS
    protein ubiquitination GO:0016567 IBA
    modification-dependent protein catabolic process GO:0019941 IBA
    protein modification process GO:0036211 TAS
Subcellular Localization
    extracellular space GO:0005615 HDA
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 NAS
    mitochondrial outer membrane GO:0005741 TAS
    lysosomal membrane GO:0005765 HDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    endosome membrane GO:0010008 TAS
    cytosolic large ribosomal subunit GO:0022625 HDA
    cytosolic large ribosomal subunit GO:0022625 IDA
    cytosolic large ribosomal subunit GO:0022625 IPI
    cytosolic ribosome GO:0022626 IDA
    cytosolic ribosome GO:0022626 IDA
    endocytic vesicle membrane GO:0030666 TAS
    vesicle GO:0031982 HDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified UBA52 in sEVs
1
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 20
MISEV standards
✔
EM
Biophysical techniques
✔
HSP90|CD63|CD81|LAMP1
Enriched markers
✔
GOLGA2|cytochrome c
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
6
Experiment ID 21
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
7
Experiment ID 1275
MISEV standards
Biophysical techniques
✔
CD9|TSG101|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 1280
MISEV standards
Biophysical techniques
✔
TSG101|CD9|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T - Fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density 1.151 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
10
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
11
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
15
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
16
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UBA52
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSMA6 5687
Affinity Capture-MS Homo sapiens
2 SLFN11 91607
Proximity Label-MS Homo sapiens
3 ST8SIA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 GJD3  
Proximity Label-MS Homo sapiens
6 RAD21 5885
Affinity Capture-Western Homo sapiens
7 UBC 7316
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
8 CBX1 10951
Cross-Linking-MS (XL-MS) Homo sapiens
9 SPRTN  
Affinity Capture-MS Homo sapiens
10 UBE2A  
Co-fractionation Homo sapiens
11 OCLN 100506658
Proximity Label-MS Homo sapiens
12 METTL7A 25840
Proximity Label-MS Homo sapiens
13 RPL4 6124
Co-fractionation Homo sapiens
14 HIST1H4A 8359
Cross-Linking-MS (XL-MS) Homo sapiens
15 GJA1 2697
Proximity Label-MS Homo sapiens
16 NAA40  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 NEB 4703
Cross-Linking-MS (XL-MS) Homo sapiens
18 PTX3 5806
Affinity Capture-MS Homo sapiens
19 TNRC18  
Cross-Linking-MS (XL-MS) Homo sapiens
20 EIF2B2 8892
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 PEX1 5189
Affinity Capture-MS Homo sapiens
22 SUB1 10923
Affinity Capture-MS Homo sapiens
23 FUOM  
Affinity Capture-MS Homo sapiens
24 PLSCR4  
Two-hybrid Homo sapiens
25 RPS19 6223
Co-fractionation Homo sapiens
26 HIST1H2BB 3018
Cross-Linking-MS (XL-MS) Homo sapiens
27 HSD17B11 51170
Proximity Label-MS Homo sapiens
28 HSP90AB1 3326
Co-fractionation Homo sapiens
29 HIST3H2BB 128312
Cross-Linking-MS (XL-MS) Homo sapiens
30 VAMP2 6844
Co-fractionation Homo sapiens
31 LOC100132735  
Protein-RNA Homo sapiens
32 PSMD11 5717
Affinity Capture-MS Homo sapiens
33 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
34 PSMC6 5706
Affinity Capture-MS Homo sapiens
35 CFL1 1072
Co-fractionation Homo sapiens
36 HIST2H2BF 440689
Cross-Linking-MS (XL-MS) Homo sapiens
37 STX4 6810
Proximity Label-MS Homo sapiens
38 GAPDH 2597
Affinity Capture-MS Homo sapiens
39 SNRPD2 6633
Cross-Linking-MS (XL-MS) Homo sapiens
40 H2AFV 94239
Cross-Linking-MS (XL-MS) Homo sapiens
41 RPS3 6188
Co-fractionation Homo sapiens
42 UFC1 51506
Co-fractionation Homo sapiens
43 HIST2H2AA3 8337
Cross-Linking-MS (XL-MS) Homo sapiens
44 RNH1 6050
Affinity Capture-MS Homo sapiens
45 CHCHD4  
Affinity Capture-MS Homo sapiens
46 PARK2  
Affinity Capture-MS Homo sapiens
47 RPS20 6224
Co-fractionation Homo sapiens
48 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
49 B3GAT1  
Proximity Label-MS Homo sapiens
50 B3GNT2 10678
Affinity Capture-MS Homo sapiens
51 HIST3H2A 92815
Cross-Linking-MS (XL-MS) Homo sapiens
52 MTURN  
Two-hybrid Homo sapiens
53 MCM2 4171
Affinity Capture-MS Homo sapiens
54 UBE2K 3093
Affinity Capture-MS Homo sapiens
55 SLC13A2 9058
Affinity Capture-MS Homo sapiens
56 C18orf25 147339
Affinity Capture-MS Homo sapiens
57 PHLDA2 7262
Cross-Linking-MS (XL-MS) Homo sapiens
58 CCAR2 57805
Affinity Capture-MS Homo sapiens
59 TTN 7273
Cross-Linking-MS (XL-MS) Homo sapiens
60 HIST2H3A 333932
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
61 RPL24 6152
Co-fractionation Homo sapiens
62 UBL4A 8266
Affinity Capture-MS Homo sapiens
63 PSMD12 5718
Affinity Capture-MS Homo sapiens
64 MDH1 4190
Affinity Capture-MS Homo sapiens
65 FBLN2 2199
Affinity Capture-MS Homo sapiens
66 TAX1BP1 8887
Two-hybrid Homo sapiens
67 C11orf52 91894
Proximity Label-MS Homo sapiens
68 HMGA1 3159
Cross-Linking-MS (XL-MS) Homo sapiens
69 UBQLN1 29979
Two-hybrid Homo sapiens
70 AHCY 191
Co-fractionation Homo sapiens
71 RSRC1  
Affinity Capture-MS Homo sapiens
72 RGS20 8601
Affinity Capture-MS Homo sapiens
73 ITGA4 3676
Affinity Capture-MS Homo sapiens
74 DGCR2 9993
Affinity Capture-MS Homo sapiens
75 PLA2G10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 MT1M 4499
Affinity Capture-MS Homo sapiens
77 PRDX4 10549
Affinity Capture-MS Homo sapiens
78 MTHFR 4524
Affinity Capture-MS Homo sapiens
79 PGK2 5232
Cross-Linking-MS (XL-MS) Homo sapiens
80 ZSCAN18  
Co-fractionation Homo sapiens
81 UFM1 51569
Co-fractionation Homo sapiens
82 Mcm3 17215
Affinity Capture-MS Mus musculus
83 RAB35 11021
Proximity Label-MS Homo sapiens
84 MYCN  
Affinity Capture-MS Homo sapiens
85 WBP2 23558
Two-hybrid Homo sapiens
86 USP7 7874
Biochemical Activity Homo sapiens
87 NCK1 4690
Two-hybrid Homo sapiens
88 EBAG9 9166
Proximity Label-MS Homo sapiens
89 RAD23A 5886
Two-hybrid Homo sapiens
90 RPS2 6187
Co-fractionation Homo sapiens
91 RNF11 26994
Two-hybrid Homo sapiens
92 PES1 23481
Co-fractionation Homo sapiens
93 UNK  
Co-fractionation Homo sapiens
94 PXMP2  
Proximity Label-MS Homo sapiens
95 RABGEF1 27342
Two-hybrid Homo sapiens
96 LOC102724334 102724334
Cross-Linking-MS (XL-MS) Homo sapiens
97 PNPLA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 ATP2A2 488
Cross-Linking-MS (XL-MS) Homo sapiens
99 MTCH2 23788
Affinity Capture-MS Homo sapiens
100 MIB1 57534
Proximity Label-MS Homo sapiens
101 Uch 33397
Biochemical Activity Drosophila melanogaster
102 GCNT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 USP11 8237
Affinity Capture-MS Homo sapiens
104 HMGCS1 3157
Affinity Capture-MS Homo sapiens
105 HIST1H2BM 8342
Cross-Linking-MS (XL-MS) Homo sapiens
106 PLEKHB2 55041
Two-hybrid Homo sapiens
107 CXADR 1525
Proximity Label-MS Homo sapiens
108 CLSTN1 22883
Affinity Capture-MS Homo sapiens
109 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
110 MEPCE 56257
Affinity Capture-MS Homo sapiens
111 CLNS1A 1207
Co-fractionation Homo sapiens
112 SPIN2A  
Affinity Capture-MS Homo sapiens
113 LYN 4067
Proximity Label-MS Homo sapiens
114 PSMD14 10213
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 MTMR4  
Affinity Capture-MS Homo sapiens
116 KLK1 3816
Affinity Capture-MS Homo sapiens
117 DAZAP2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
118 LAPTM5 7805
Two-hybrid Homo sapiens
119 RPL18A 6142
Co-fractionation Homo sapiens
120 HIST1H2BN 8341
Cross-Linking-MS (XL-MS) Homo sapiens
121 MMAB 326625
Affinity Capture-MS Homo sapiens
122 CCNT2  
Affinity Capture-MS Homo sapiens
123 VCP 7415
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 SLC43A3 29015
Affinity Capture-MS Homo sapiens
125 FLOT1 10211
Proximity Label-MS Homo sapiens
126 UBE2L3 7332
Cross-Linking-MS (XL-MS) Homo sapiens
127 TPI1 7167
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
128 HIST1H1E 3008
Cross-Linking-MS (XL-MS) Homo sapiens
129 FAM135A  
Affinity Capture-MS Homo sapiens
130 STK17B 9262
Affinity Capture-MS Homo sapiens
131 PEX14 5195
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 RPL36 25873
Co-fractionation Homo sapiens
133 SMAD2 4087
Two-hybrid Homo sapiens
134 ARRDC3 57561
Two-hybrid Homo sapiens
135 RPL27A 6157
Co-fractionation Homo sapiens
136 PSMC1 5700
Affinity Capture-MS Homo sapiens
137 MDM2  
Affinity Capture-Western Homo sapiens
138 UBE2D3 7323
Cross-Linking-MS (XL-MS) Homo sapiens
139 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
140 Ube2i  
Two-hybrid Mus musculus
141 ACTR10 55860
Cross-Linking-MS (XL-MS) Homo sapiens
142 NCL 4691
Affinity Capture-MS Homo sapiens
143 RPS15A 6210
Co-fractionation Homo sapiens
144 NPEPPS 9520
Affinity Capture-MS Homo sapiens
145 SEC61B 10952
Proximity Label-MS Homo sapiens
146 LUCAT1  
Affinity Capture-RNA Homo sapiens
147 HIST1H2AB 8335
Cross-Linking-MS (XL-MS) Homo sapiens
148 NEIL3  
Affinity Capture-MS Homo sapiens
149 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
150 HIST2H2BE 8349
Cross-Linking-MS (XL-MS) Homo sapiens
151 RNF216P1  
Affinity Capture-MS Homo sapiens
152 DKK3 27122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 SMYD5 10322
Affinity Capture-MS Homo sapiens
154 HIST1H2BL 8340
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
155 UBE2N 7334
Cross-Linking-MS (XL-MS) Homo sapiens
156 RPL32 6161
Co-fractionation Homo sapiens
157 PKLR 5313
Affinity Capture-MS Homo sapiens
158 NUP37 79023
Affinity Capture-MS Homo sapiens
159 OAT 4942
Affinity Capture-MS Homo sapiens
160 RPLP2 6181
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
161 FANCD2  
Cross-Linking-MS (XL-MS) Homo sapiens
162 AIFM1 9131
Co-fractionation Homo sapiens
163 CDC73  
Affinity Capture-MS Homo sapiens
164 AHCYL1 10768
Co-fractionation Homo sapiens
165 CIAO1 9391
Affinity Capture-MS Homo sapiens
166 NR3C1 2908
Affinity Capture-MS Homo sapiens
167 PANX1 24145
Proximity Label-MS Homo sapiens
168 USP9X 8239
Co-fractionation Homo sapiens
169 S100A16 140576
Co-fractionation Homo sapiens
170 IFI16 3428
Affinity Capture-MS Homo sapiens
171 UBQLN2 29978
Two-hybrid Homo sapiens
172 LAMP1 3916
Proximity Label-MS Homo sapiens
173 PTH2R  
Affinity Capture-MS Homo sapiens
174 CYLC2  
Cross-Linking-MS (XL-MS) Homo sapiens
175 HSD3B7 80270
Proximity Label-MS Homo sapiens
176 RPS7 6201
Co-fractionation Homo sapiens
177 PDIA3 2923
Co-fractionation Homo sapiens
178 EGFR 1956
Negative Genetic Homo sapiens
179 YY1 7528
Cross-Linking-MS (XL-MS) Homo sapiens
180 ARF6 382
Proximity Label-MS Homo sapiens
181 FBXO6 26270
Affinity Capture-MS Homo sapiens
182 KLRG2 346689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
183 DCAF16 54876
Affinity Capture-MS Homo sapiens
184 EPRS 2058
Cross-Linking-MS (XL-MS) Homo sapiens
185 EIF2S2 8894
Affinity Capture-RNA Homo sapiens
186 NEXN 91624
Affinity Capture-MS Homo sapiens
187 ZFYVE19 84936
Co-fractionation Homo sapiens
188 HIST3H3 8290
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
189 HIST1H2BO 8348
Cross-Linking-MS (XL-MS) Homo sapiens
190 PDCD4 27250
Cross-Linking-MS (XL-MS) Homo sapiens
191 NPLOC4 55666
Affinity Capture-MS Homo sapiens
192 CEP250 11190
Cross-Linking-MS (XL-MS) Homo sapiens
193 MAPK6  
Two-hybrid Homo sapiens
194 CHRNB4  
Affinity Capture-MS Homo sapiens
195 MYC  
Affinity Capture-MS Homo sapiens
196 HIST1H2BJ 8970
Cross-Linking-MS (XL-MS) Homo sapiens
197 KLK3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
198 PPIL4  
Cross-Linking-MS (XL-MS) Homo sapiens
199 DNAJC9 23234
Cross-Linking-MS (XL-MS) Homo sapiens
200 HIST1H1C 3006
Cross-Linking-MS (XL-MS) Homo sapiens
201 RPS14 6208
Co-fractionation Homo sapiens
202 RPL35A 6165
Co-fractionation Homo sapiens
203 HSPA1A 3303
Cross-Linking-MS (XL-MS) Homo sapiens
204 PSMC5 5705
Affinity Capture-MS Homo sapiens
205 KMT2A  
Cross-Linking-MS (XL-MS) Homo sapiens
206 HK1 3098
Affinity Capture-MS Homo sapiens
207 SGTA 6449
Cross-Linking-MS (XL-MS) Homo sapiens
208 RHOB 388
Proximity Label-MS Homo sapiens
209 VDAC1 7416
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
210 SLC25A6 293
Cross-Linking-MS (XL-MS) Homo sapiens
211 MSN 4478
Co-fractionation Homo sapiens
212 SORD 6652
Cross-Linking-MS (XL-MS) Homo sapiens
213 AARS 16
Cross-Linking-MS (XL-MS) Homo sapiens
214 RAB5C 5878
Proximity Label-MS Homo sapiens
215 TAF4 6874
Cross-Linking-MS (XL-MS) Homo sapiens
216 GRB2 2885
Two-hybrid Homo sapiens
217 SMARCAL1  
Affinity Capture-MS Homo sapiens
218 HUWE1 10075
Affinity Capture-MS Homo sapiens
219 ACBD5 91452
Proximity Label-MS Homo sapiens
220 H2AFX 3014
Cross-Linking-MS (XL-MS) Homo sapiens
221 H3F3C 440093
Cross-Linking-MS (XL-MS) Homo sapiens
222 PSMB2 5690
Co-fractionation Homo sapiens
223 RPL13 6137
Co-fractionation Homo sapiens
224 RPL37 6167
Co-fractionation Homo sapiens
225 RPS27A 6233
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
226 ARRB2 409
Affinity Capture-MS Homo sapiens
227 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
228 GOT2 2806
Affinity Capture-MS Homo sapiens
229 CYP17A1 1586
Affinity Capture-MS Homo sapiens
230 SPOP  
Affinity Capture-MS Homo sapiens
231 VDAC3 7419
Co-fractionation Homo sapiens
232 RPS25 6230
Co-fractionation Homo sapiens
233 LAMTOR1 55004
Proximity Label-MS Homo sapiens
234 TMEM141  
Affinity Capture-MS Homo sapiens
235 UBE2O 63893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
236 HDGF 3068
Affinity Capture-MS Homo sapiens
237 ZRANB2 9406
Co-fractionation Homo sapiens
238 USP46 64854
Biochemical Activity Homo sapiens
239 TP53 7157
Affinity Capture-MS Homo sapiens
240 RPS21 6227
Co-fractionation Homo sapiens
241 NOTCH2 4853
Affinity Capture-MS Homo sapiens
242 EIF1AX 1964
Cross-Linking-MS (XL-MS) Homo sapiens
243 UBE2G1 7326
Affinity Capture-MS Homo sapiens
244 MCM5 4174
Affinity Capture-MS Homo sapiens
245 CTAG1B  
Affinity Capture-MS Homo sapiens
246 SEC23B 10483
Reconstituted Complex Homo sapiens
247 HNRNPA2B1 3181
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
248 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
249 RPL35 11224
Co-fractionation Homo sapiens
250 LITAF 9516
Two-hybrid Homo sapiens
251 RPS4X 6191
Co-fractionation Homo sapiens
252 Arhgap30  
Affinity Capture-MS Mus musculus
253 PDDC1 347862
Affinity Capture-MS Homo sapiens
254 CYTH1 9267
Affinity Capture-MS Homo sapiens
255 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
256 RPS5 6193
Co-fractionation Homo sapiens
257 ELOVL5 60481
Proximity Label-MS Homo sapiens
258 RPL34 6164
Co-fractionation Homo sapiens
259 PSMA1 5682
Affinity Capture-MS Homo sapiens
260 TOP2A 7153
Affinity Capture-MS Homo sapiens
261 PCNA 5111
Affinity Capture-MS Homo sapiens
262 VDAC2 7417
Co-fractionation Homo sapiens
263 FST 10468
Affinity Capture-MS Homo sapiens
264 HEXIM1 10614
Affinity Capture-MS Homo sapiens
265 UBB 7314
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
266 PPP1R13B  
Affinity Capture-MS Homo sapiens
267 RAB2A 5862
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
268 PSMA5 5686
Affinity Capture-MS Homo sapiens
269 UBE2B 7320
Co-fractionation Homo sapiens
270 H3F3A 3020
Cross-Linking-MS (XL-MS) Homo sapiens
271 ARRB1 408
Affinity Capture-MS Homo sapiens
272 ZNRF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
273 HOXA5  
Affinity Capture-MS Homo sapiens
274 TRIM31  
Affinity Capture-MS Homo sapiens
275 TCAF1 9747
Affinity Capture-MS Homo sapiens
276 SSSCA1 10534
Co-fractionation Homo sapiens
277 RPS8 6202
Co-fractionation Homo sapiens
278 Cdc6 23834
Affinity Capture-MS Mus musculus
279 ZUFSP 221302
Affinity Capture-MS Homo sapiens
280 TXNIP 10628
Affinity Capture-MS Homo sapiens
281 KRAS 3845
Proximity Label-MS Homo sapiens
Negative Genetic Homo sapiens
282 HNRNPU 3192
Affinity Capture-MS Homo sapiens
283 CYCS 54205
Affinity Capture-MS Homo sapiens
284 SERBP1 26135
Affinity Capture-MS Homo sapiens
285 SMURF2 64750
Affinity Capture-MS Homo sapiens
286 ANXA2 302
Co-fractionation Homo sapiens
287 CCNT1  
Affinity Capture-MS Homo sapiens
288 VAV3 10451
Affinity Capture-MS Homo sapiens
289 FLAD1 80308
Affinity Capture-MS Homo sapiens
290 CAV1 857
Proximity Label-MS Homo sapiens
291 ATP5A1 498
Affinity Capture-MS Homo sapiens
292 RPL17 6139
Co-fractionation Homo sapiens
293 ALDOA 226
Affinity Capture-MS Homo sapiens
294 CHMP1A 5119
Cross-Linking-MS (XL-MS) Homo sapiens
295 HIST1H2BA 255626
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which UBA52 is involved
PathwayEvidenceSource
ABC transporter disorders TAS Reactome
ABC-family proteins mediated transport TAS Reactome
Activated NOTCH1 Transmits Signal to the Nucleus IEA Reactome
Activated NOTCH1 Transmits Signal to the Nucleus TAS Reactome
activated TAK1 mediates p38 MAPK activation TAS Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) TAS Reactome
Activation of NF-kappaB in B cells TAS Reactome
Adaptive Immune System TAS Reactome
Adaptive Immune System IEA Reactome
Aerobic respiration and respiratory electron transport TAS Reactome
Aggrephagy IEA Reactome
Aggrephagy TAS Reactome
Alpha-protein kinase 1 signaling pathway TAS Reactome
Amyloid fiber formation TAS Reactome
Antigen processing-Cross presentation IEA Reactome
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome
Antiviral mechanism by IFN-stimulated genes TAS Reactome
APC-Cdc20 mediated degradation of Nek2A TAS Reactome
APC/C-mediated degradation of cell cycle proteins TAS Reactome
APC/C:Cdc20 mediated degradation of Cyclin B TAS Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
APC/C:Cdc20 mediated degradation of Securin TAS Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 TAS Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint TAS Reactome
Apoptosis IEA Reactome
Asparagine N-linked glycosylation TAS Reactome
Assembly Of The HIV Virion TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
Asymmetric localization of PCP proteins TAS Reactome
AUF1 (hnRNP D0) binds and destabilizes mRNA TAS Reactome
Autodegradation of Cdh1 by Cdh1:APC/C TAS Reactome
Autodegradation of the E3 ubiquitin ligase COP1 TAS Reactome
Autophagy IEA Reactome
Autophagy TAS Reactome
Axon guidance TAS Reactome
Axon guidance IEA Reactome
Bacterial Infection Pathways TAS Reactome
Bacterial Infection Pathways IEA Reactome
Beta-catenin independent WNT signaling TAS Reactome
Budding and maturation of HIV virion TAS Reactome
C-type lectin receptors (CLRs) TAS Reactome
Calnexin/calreticulin cycle TAS Reactome
Cap-dependent Translation Initiation TAS Reactome
Cargo recognition for clathrin-mediated endocytosis TAS Reactome
Cdc20:Phospho-APC/C mediated degradation of Cyclin A TAS Reactome
CDK-mediated phosphorylation and removal of Cdc6 TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cell death signalling via NRAGE, NRIF and NADE TAS Reactome
Cellular response to chemical stress TAS Reactome
Cellular response to hypoxia TAS Reactome
Cellular response to starvation IEA Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress TAS Reactome
Cellular responses to stress IEA Reactome
Cellular Senescence TAS Reactome
Chaperone Mediated Autophagy IEA Reactome
Circadian Clock IEA Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
Class I MHC mediated antigen processing & presentation IEA Reactome
Clathrin-mediated endocytosis TAS Reactome
CLEC7A (Dectin-1) signaling TAS Reactome
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants TAS Reactome
Constitutive Signaling by NOTCH1 HD Domain Mutants TAS Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants TAS Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants TAS Reactome
Cyclin A:Cdk2-associated events at S phase entry TAS Reactome
Cyclin D associated events in G1 TAS Reactome
Cyclin E associated events during G1/S transition TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
Cytosolic sensors of pathogen-associated DNA TAS Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta TAS Reactome
Deactivation of the beta-catenin transactivating complex TAS Reactome
Death Receptor Signaling TAS Reactome
Dectin-1 mediated noncanonical NF-kB signaling TAS Reactome
Defective CFTR causes cystic fibrosis TAS Reactome
Degradation of AXIN TAS Reactome
Degradation of beta-catenin by the destruction complex TAS Reactome
Degradation of DVL TAS Reactome
Degradation of GLI1 by the proteasome TAS Reactome
Degradation of GLI2 by the proteasome IEA Reactome
Deubiquitination TAS Reactome
Deubiquitination IEA Reactome
Developmental Biology TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Disease IEA Reactome
Diseases of carbohydrate metabolism TAS Reactome
Diseases of metabolism TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Disorders of transmembrane transporters TAS Reactome
DNA Damage Bypass TAS Reactome
DNA Damage Recognition in GG-NER TAS Reactome
DNA Double Strand Break Response TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA Repair TAS Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
Downregulation of ERBB2 signaling TAS Reactome
Downregulation of ERBB2:ERBB3 signaling TAS Reactome
Downregulation of ERBB4 signaling TAS Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity TAS Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity IEA Reactome
Downregulation of TGF-beta receptor signaling IEA Reactome
Downregulation of TGF-beta receptor signaling TAS Reactome
Downstream signaling events of B Cell Receptor (BCR) TAS Reactome
Downstream TCR signaling TAS Reactome
Dual Incision in GG-NER TAS Reactome
Dual incision in TC-NER TAS Reactome
E3 ubiquitin ligases ubiquitinate target proteins TAS Reactome
EGFR downregulation TAS Reactome
Endosomal Sorting Complex Required For Transport (ESCRT) TAS Reactome
ER Quality Control Compartment (ERQC) TAS Reactome
ER-Phagosome pathway IEA Reactome
Eukaryotic Translation Elongation IEA Reactome
Eukaryotic Translation Initiation TAS Reactome
Eukaryotic Translation Termination IEA Reactome
Evasion by RSV of host interferon responses TAS Reactome
Fanconi Anemia Pathway TAS Reactome
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
FCERI mediated NF-kB activation TAS Reactome
FLT3 Signaling TAS Reactome
FLT3 signaling by CBL mutants TAS Reactome
FLT3 signaling in disease TAS Reactome
Formation of a pool of free 40S subunits TAS Reactome
Formation of Incision Complex in GG-NER TAS Reactome
Formation of TC-NER Pre-Incision Complex TAS Reactome
G1 Phase TAS Reactome
G1/S DNA Damage Checkpoints TAS Reactome
G1/S Transition TAS Reactome
G2/M Checkpoints TAS Reactome
G2/M Transition TAS Reactome
Gap-filling DNA repair synthesis and ligation in GG-NER TAS Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
GLI3 is processed to GLI3R by the proteasome TAS Reactome
Global Genome Nucleotide Excision Repair (GG-NER) TAS Reactome
Glycogen metabolism TAS Reactome
Glycogen storage diseases TAS Reactome
Glycogen synthesis TAS Reactome
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 TAS Reactome
GTP hydrolysis and joining of the 60S ribosomal subunit TAS Reactome
HDR through Homologous Recombination (HRR) TAS Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) TAS Reactome
Hedgehog 'off' state TAS Reactome
Hedgehog 'off' state IEA Reactome
Hedgehog 'on' state TAS Reactome
Hedgehog 'on' state IEA Reactome
Hedgehog ligand biogenesis TAS Reactome
Hh mutants abrogate ligand secretion TAS Reactome
Hh mutants are degraded by ERAD TAS Reactome
HIV Infection TAS Reactome
HIV Life Cycle TAS Reactome
Homology Directed Repair TAS Reactome
Host Interactions of HIV factors TAS Reactome
IKK complex recruitment mediated by RIP1 TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Inactivation of CSF3 (G-CSF) signaling TAS Reactome
Infection with Mycobacterium tuberculosis TAS Reactome
Infectious disease TAS Reactome
Infectious disease IEA Reactome
Influenza Infection TAS Reactome
Influenza Viral RNA Transcription and Replication TAS Reactome
InlA-mediated entry of Listeria monocytogenes into host cells TAS Reactome
InlB-mediated entry of Listeria monocytogenes into host cell TAS Reactome
InlB-mediated entry of Listeria monocytogenes into host cell IEA Reactome
Innate Immune System TAS Reactome
Interferon alpha/beta signaling TAS Reactome
Interferon Signaling TAS Reactome
Interleukin-1 family signaling TAS Reactome
Interleukin-1 signaling TAS Reactome
Interleukin-17 signaling TAS Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling TAS Reactome
Intracellular signaling by second messengers TAS Reactome
Ion channel transport TAS Reactome
IRAK1 recruits IKK complex TAS Reactome
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation TAS Reactome
IRAK2 mediated activation of TAK1 complex TAS Reactome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TAS Reactome
Iron uptake and transport TAS Reactome
ISG15 antiviral mechanism TAS Reactome
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TAS Reactome
Josephin domain DUBs TAS Reactome
KEAP1-NFE2L2 pathway TAS Reactome
L13a-mediated translational silencing of Ceruloplasmin expression TAS Reactome
Late endosomal microautophagy IEA Reactome
Late Phase of HIV Life Cycle TAS Reactome
Late SARS-CoV-2 Infection Events IEA Reactome
Listeria monocytogenes entry into host cells TAS Reactome
Listeria monocytogenes entry into host cells IEA Reactome
M Phase TAS Reactome
Macroautophagy TAS Reactome
Macroautophagy IEA Reactome
Major pathway of rRNA processing in the nucleolus and cytosol TAS Reactome
MAP kinase activation TAS Reactome
MAP3K8 (TPL2)-dependent MAPK1/3 activation TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
MAPK6/MAPK4 signaling TAS Reactome
Maturation of protein E TAS Reactome
Maturation of protein E IEA Reactome
Membrane binding and targetting of GAG proteins TAS Reactome
Membrane Trafficking TAS Reactome
Metabolism TAS Reactome
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome
Metabolism of carbohydrates TAS Reactome
Metabolism of proteins TAS Reactome
Metabolism of proteins IEA Reactome
Metabolism of RNA TAS Reactome
Metalloprotease DUBs TAS Reactome
Mitophagy TAS Reactome
Mitotic Anaphase TAS Reactome
Mitotic G1 phase and G1/S transition TAS Reactome
Mitotic G2-G2/M phases TAS Reactome
Mitotic Metaphase and Anaphase TAS Reactome
Modulation by Mtb of host immune system TAS Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
Myoclonic epilepsy of Lafora TAS Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle TAS Reactome
Neddylation TAS Reactome
Negative regulation of FGFR1 signaling TAS Reactome
Negative regulation of FGFR2 signaling TAS Reactome
Negative regulation of FGFR3 signaling TAS Reactome
Negative regulation of FGFR4 signaling TAS Reactome
Negative regulation of FLT3 TAS Reactome
Negative regulation of MAPK pathway TAS Reactome
Negative regulation of MET activity TAS Reactome
Negative regulation of NOTCH4 signaling IEA Reactome
Negative regulators of DDX58/IFIH1 signaling TAS Reactome
Nervous system development TAS Reactome
Nervous system development IEA Reactome
NF-kB is activated and signals survival TAS Reactome
NIK-->noncanonical NF-kB signaling TAS Reactome
NOD1/2 Signaling Pathway TAS Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) TAS Reactome
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) TAS Reactome
Nonsense-Mediated Decay (NMD) TAS Reactome
NOTCH1 Intracellular Domain Regulates Transcription IEA Reactome
NOTCH2 Activation and Transmission of Signal to the Nucleus IEA Reactome
NOTCH3 Activation and Transmission of Signal to the Nucleus IEA Reactome
NOTCH3 Activation and Transmission of Signal to the Nucleus TAS Reactome
NRIF signals cell death from the nucleus TAS Reactome
Nuclear events mediated by NFE2L2 TAS Reactome
Nucleotide Excision Repair TAS Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TAS Reactome
Oncogene Induced Senescence TAS Reactome
Orc1 removal from chromatin TAS Reactome
Ovarian tumor domain proteases TAS Reactome
Oxidative Stress Induced Senescence TAS Reactome
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TAS Reactome
p53-Dependent G1 DNA Damage Response TAS Reactome
p53-Dependent G1/S DNA damage checkpoint TAS Reactome
p53-Independent DNA Damage Response TAS Reactome
p53-Independent G1/S DNA damage checkpoint TAS Reactome
p75 NTR receptor-mediated signalling TAS Reactome
p75NTR recruits signalling complexes TAS Reactome
p75NTR signals via NF-kB TAS Reactome
PCP/CE pathway TAS Reactome
Peptide chain elongation IEA Reactome
Peroxisomal protein import IEA Reactome
Peroxisomal protein import TAS Reactome
Pexophagy TAS Reactome
PINK1-PRKN Mediated Mitophagy TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Plasma lipoprotein assembly, remodeling, and clearance TAS Reactome
Plasma lipoprotein clearance TAS Reactome
Post-translational protein modification TAS Reactome
Post-translational protein modification IEA Reactome
Prevention of phagosomal-lysosomal fusion TAS Reactome
Processing of DNA double-strand break ends TAS Reactome
Programmed Cell Death IEA Reactome
Programmed Cell Death TAS Reactome
Protein localization IEA Reactome
Protein localization TAS Reactome
Protein ubiquitination TAS Reactome
Protein ubiquitination IEA Reactome
PTEN Regulation TAS Reactome
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 TAS Reactome
Pyruvate metabolism TAS Reactome
RAF/MAP kinase cascade TAS Reactome
RAS processing TAS Reactome
Recognition of DNA damage by PCNA-containing replication complex TAS Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TAS Reactome
Regulated Necrosis TAS Reactome
Regulation of activated PAK-2p34 by proteasome mediated degradation IEA Reactome
Regulation of APC/C activators between G1/S and early anaphase TAS Reactome
Regulation of Apoptosis IEA Reactome
Regulation of BACH1 activity TAS Reactome
Regulation of expression of SLITs and ROBOs TAS Reactome
Regulation of expression of SLITs and ROBOs IEA Reactome
Regulation of FZD by ubiquitination TAS Reactome
Regulation of innate immune responses to cytosolic DNA TAS Reactome
Regulation of mitotic cell cycle TAS Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements TAS Reactome
Regulation of necroptotic cell death TAS Reactome
Regulation of NF-kappa B signaling TAS Reactome
Regulation of PLK1 Activity at G2/M Transition TAS Reactome
Regulation of PTEN localization TAS Reactome
Regulation of PTEN stability and activity TAS Reactome
Regulation of pyruvate metabolism TAS Reactome
Regulation of RAS by GAPs TAS Reactome
Regulation of RUNX2 expression and activity IEA Reactome
Regulation of RUNX2 expression and activity TAS Reactome
Regulation of RUNX3 expression and activity TAS Reactome
Regulation of signaling by CBL TAS Reactome
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 TAS Reactome
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation TAS Reactome
Regulation of TNFR1 signaling TAS Reactome
Regulation of TP53 Activity TAS Reactome
Regulation of TP53 Activity through Methylation TAS Reactome
Regulation of TP53 Activity through Phosphorylation TAS Reactome
Regulation of TP53 Degradation TAS Reactome
Regulation of TP53 Expression and Degradation TAS Reactome
Respiratory Syncytial Virus Infection Pathway TAS Reactome
Response of EIF2AK4 (GCN2) to amino acid deficiency IEA Reactome
Response of Mtb to phagocytosis TAS Reactome
RIPK1-mediated regulated necrosis TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
rRNA processing TAS Reactome
rRNA processing in the nucleus and cytosol TAS Reactome
RSV-host interactions TAS Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs TAS Reactome
S Phase TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV Infections IEA Reactome
SARS-CoV-1 activates/modulates innate immune responses TAS Reactome
SARS-CoV-1 Infection TAS Reactome
SARS-CoV-1-host interactions TAS Reactome
SARS-CoV-2 activates/modulates innate and adaptive immune responses TAS Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2 Infection IEA Reactome
SARS-CoV-2-host interactions TAS Reactome
SCF(Skp2)-mediated degradation of p27/p21 TAS Reactome
SCF-beta-TrCP mediated degradation of Emi1 TAS Reactome
Selective autophagy TAS Reactome
Selective autophagy IEA Reactome
Selenoamino acid metabolism IEA Reactome
Selenocysteine synthesis IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Separation of Sister Chromatids TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
Signaling by CSF1 (M-CSF) in myeloid cells IEA Reactome
Signaling by CSF3 (G-CSF) TAS Reactome
Signaling by EGFR TAS Reactome
Signaling by EGFR in Cancer TAS Reactome
Signaling by ERBB2 TAS Reactome
Signaling by ERBB4 TAS Reactome
Signaling by FGFR TAS Reactome
Signaling by FGFR1 TAS Reactome
Signaling by FGFR2 TAS Reactome
Signaling by FGFR3 TAS Reactome
Signaling by FGFR4 TAS Reactome
Signaling by Hedgehog TAS Reactome
Signaling by Hedgehog IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by Ligand-Responsive EGFR Variants in Cancer TAS Reactome
Signaling by MET TAS Reactome
Signaling by Non-Receptor Tyrosine Kinases TAS Reactome
Signaling by NOTCH IEA Reactome
Signaling by NOTCH TAS Reactome
Signaling by NOTCH1 IEA Reactome
Signaling by NOTCH1 TAS Reactome
Signaling by NOTCH1 HD Domain Mutants in Cancer TAS Reactome
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer TAS Reactome
Signaling by NOTCH1 in Cancer TAS Reactome
Signaling by NOTCH1 PEST Domain Mutants in Cancer TAS Reactome
Signaling by NOTCH2 IEA Reactome
Signaling by NOTCH3 IEA Reactome
Signaling by NOTCH3 TAS Reactome
Signaling by NOTCH4 IEA Reactome
Signaling by PTK6 TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by ROBO receptors TAS Reactome
Signaling by ROBO receptors IEA Reactome
Signaling by TGF-beta Receptor Complex TAS Reactome
Signaling by TGF-beta Receptor Complex IEA Reactome
Signaling by TGFB family members TAS Reactome
Signaling by TGFB family members IEA Reactome
Signaling by the B Cell Receptor (BCR) TAS Reactome
Signaling by WNT TAS Reactome
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription IEA Reactome
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TAS Reactome
Spry regulation of FGF signaling TAS Reactome
SRP-dependent cotranslational protein targeting to membrane IEA Reactome
SRP-dependent cotranslational protein targeting to membrane TAS Reactome
Stabilization of p53 TAS Reactome
Stimuli-sensing channels TAS Reactome
Suppression of phagosomal maturation TAS Reactome
Switching of origins to a post-replicative state TAS Reactome
Synthesis And Processing Of GAG, GAGPOL Polyproteins TAS Reactome
Synthesis of active ubiquitin: roles of E1 and E2 enzymes TAS Reactome
Synthesis of active ubiquitin: roles of E1 and E2 enzymes IEA Reactome
Synthesis of DNA TAS Reactome
TAK1-dependent IKK and NF-kappa-B activation TAS Reactome
TCF dependent signaling in response to WNT TAS Reactome
TCR signaling TAS Reactome
Termination of translesion DNA synthesis TAS Reactome
TGF-beta receptor signaling activates SMADs IEA Reactome
TGF-beta receptor signaling activates SMADs TAS Reactome
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TAS Reactome
The role of GTSE1 in G2/M progression after G2 checkpoint TAS Reactome
TICAM1, RIP1-mediated IKK complex recruitment TAS Reactome
TICAM1,TRAF6-dependent induction of TAK1 complex TAS Reactome
TICAM1-dependent activation of IRF3/IRF7 TAS Reactome
TNF signaling TAS Reactome
TNFR1-induced NF-kappa-B signaling pathway TAS Reactome
TNFR2 non-canonical NF-kB pathway TAS Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TAS Reactome
TRAF6-mediated induction of TAK1 complex within TLR4 complex TAS Reactome
Transcription-Coupled Nucleotide Excision Repair (TC-NER) TAS Reactome
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer TAS Reactome
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IEA Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by RUNX2 IEA Reactome
Transcriptional regulation by RUNX2 TAS Reactome
Transcriptional regulation by RUNX3 TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome
Translation TAS Reactome
Translation IEA Reactome
Translation of Structural Proteins TAS Reactome
Translation of Structural Proteins IEA Reactome
Translesion Synthesis by POLH TAS Reactome
Translesion synthesis by POLI TAS Reactome
Translesion synthesis by POLK TAS Reactome
Translesion synthesis by REV1 TAS Reactome
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template TAS Reactome
Transport of small molecules TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
Ub-specific processing proteases TAS Reactome
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TAS Reactome
Ubiquitin-dependent degradation of Cyclin D TAS Reactome
UCH proteinases IEA Reactome
UCH proteinases TAS Reactome
Vesicle-mediated transport TAS Reactome
Vif-mediated degradation of APOBEC3G TAS Reactome
Viral Infection Pathways TAS Reactome
Viral Infection Pathways IEA Reactome
Viral mRNA Translation TAS Reactome
VLDLR internalisation and degradation TAS Reactome
Vpu mediated degradation of CD4 TAS Reactome





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