Gene description for HMGA1
Gene name high mobility group AT-hook 1
Gene symbol HMGA1
Other names/aliases HMG-R
HMGA1A
HMGIY
Species Homo sapiens
 Database cross references - HMGA1
ExoCarta ExoCarta_3159
Vesiclepedia VP_3159
Entrez Gene 3159
HGNC 5010
MIM 600701
UniProt P17096  
 HMGA1 identified in sEVs derived from the following tissue/cell type
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 35918900    
Breast cancer cells 35918900    
Chondrocytes 35931686    
Chondrocytes 35931686    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Prostate cancer cells 25844599    
Squamous carcinoma cells 20124223    
T lymphocytes 34108659    
 Gene ontology annotations for HMGA1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISS
    cis-regulatory region sequence-specific DNA binding GO:0000987 IDA
    transcription coregulator binding GO:0001221 IDA
    DNA binding GO:0003677 EXP
    DNA binding GO:0003677 IDA
    minor groove of adenine-thymine-rich DNA binding GO:0003680 IDA
    minor groove of adenine-thymine-rich DNA binding GO:0003680 ISS
    minor groove of adenine-thymine-rich DNA binding GO:0003680 TAS
    chromatin binding GO:0003682 ISS
    transcription coregulator activity GO:0003712 IBA
    transcription coactivator activity GO:0003713 EXP
    transcription coactivator activity GO:0003713 IMP
    transcription coactivator activity GO:0003713 ISS
    RNA binding GO:0003723 IPI
    DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906 IDA
    protein binding GO:0005515 IPI
    DNA binding, bending GO:0008301 EXP
    enzyme binding GO:0019899 IPI
    nuclear receptor coactivator activity GO:0030374 IMP
    structural constituent of chromatin GO:0030527 TAS
    nuclear retinoic acid receptor binding GO:0042974 IDA
    peroxisome proliferator activated receptor binding GO:0042975 IDA
    nuclear retinoid X receptor binding GO:0046965 IDA
    5'-deoxyribose-5-phosphate lyase activity GO:0051575 IDA
    molecular adaptor activity GO:0060090 IDA
    molecular function activator activity GO:0140677 IMP
Biological Process
    DNA unwinding involved in DNA replication GO:0006268 NAS
    base-excision repair GO:0006284 IDA
    nucleosome disassembly GO:0006337 TAS
    regulation of DNA-templated transcription GO:0006355 IBA
    negative regulation of cell population proliferation GO:0008285 IMP
    negative regulation of DNA-templated transcription GO:0045892 IMP
    positive regulation of DNA-templated transcription GO:0045893 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    oncogene-induced cell senescence GO:0090402 IDA
Subcellular Localization
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 TAS
    cytosol GO:0005829 TAS
    focal adhesion GO:0005925 HDA
    senescence-associated heterochromatin focus GO:0035985 IDA
    RNA polymerase II transcription regulator complex GO:0090575 ISS
 Experiment description of studies that identified HMGA1 in sEVs
1
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
2
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
3
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 1334
MISEV standards
Biophysical techniques
✔
CD9
Enriched markers
✔
ACTB
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35918900    
Organism Homo sapiens
Experiment description Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL)
Authors "Bauzá-Martinez J, Armony G, Pronker MF, Wu W. "
Journal name J Extracell Vesicles
Publication year 2022
Sample Breast cancer cells
Sample name LM2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectometry
6
Experiment ID 1336
MISEV standards
Biophysical techniques
✔
CD9
Enriched markers
✔
ACTB
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35918900    
Organism Homo sapiens
Experiment description Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL)
Authors "Bauzá-Martinez J, Armony G, Pronker MF, Wu W. "
Journal name J Extracell Vesicles
Publication year 2022
Sample Breast cancer cells
Sample name LM2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectometry
7
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
10
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
15
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 234
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
19
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
20
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
21
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
22
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
23
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
24
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
25
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
28
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
29
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
30
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
31
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
32
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
33
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
34
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
35
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
36
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
37
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
38
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
39
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for HMGA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDC14B 8555
Proximity Label-MS Homo sapiens
2 SLFN11 91607
Affinity Capture-MS Homo sapiens
3 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 MCM7 4176
Affinity Capture-MS Homo sapiens
6 ORC2  
Affinity Capture-Western Homo sapiens
7 MSL1 339287
Affinity Capture-MS Homo sapiens
8 CBX1 10951
Affinity Capture-MS Homo sapiens
9 KPNA3 3839
Affinity Capture-MS Homo sapiens
10 HDAC2 3066
Co-localization Homo sapiens
11 ELF1 1997
Reconstituted Complex Homo sapiens
12 TOP2B 7155
Affinity Capture-MS Homo sapiens
13 XPC  
Affinity Capture-MS Homo sapiens
14 RACGAP1 29127
Affinity Capture-MS Homo sapiens
15 HIST1H1D 3007
Affinity Capture-MS Homo sapiens
16 SP1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
17 NFATC1 4772
Affinity Capture-MS Homo sapiens
18 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
19 CABIN1  
Affinity Capture-MS Homo sapiens
20 HIST1H2BJ 8970
Cross-Linking-MS (XL-MS) Homo sapiens
21 BRD7  
Affinity Capture-MS Homo sapiens
22 PRMT6  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 KIF20A 10112
Affinity Capture-MS Homo sapiens
24 USP9X 8239
Affinity Capture-MS Homo sapiens
25 CDC26 246184
Affinity Capture-MS Homo sapiens
26 CSNK2A1 1457
Biochemical Activity Homo sapiens
27 Csk 12988
Affinity Capture-MS Mus musculus
28 PARK7 11315
Affinity Capture-MS Homo sapiens
29 PRKDC 5591
Affinity Capture-MS Homo sapiens
30 APP 351
Reconstituted Complex Homo sapiens
31 CENPA  
Proximity Label-MS Homo sapiens
32 APEX1 328
Cross-Linking-MS (XL-MS) Homo sapiens
33 KAT7  
Affinity Capture-MS Homo sapiens
34 DPPA4  
Affinity Capture-MS Homo sapiens
35 CHRAC1  
Affinity Capture-MS Homo sapiens
36 TOP2A 7153
Affinity Capture-MS Homo sapiens
37 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
38 SRCAP  
Affinity Capture-MS Homo sapiens
39 HP1BP3 50809
Affinity Capture-MS Homo sapiens
40 MTF2  
Affinity Capture-MS Homo sapiens
41 VPS72  
Affinity Capture-MS Homo sapiens
42 HIST1H2BM 8342
Cross-Linking-MS (XL-MS) Homo sapiens
43 MCM2 4171
Affinity Capture-MS Homo sapiens
44 BAZ1A 11177
Affinity Capture-MS Homo sapiens
45 H1FX 8971
Affinity Capture-MS Homo sapiens
46 INIP  
Affinity Capture-MS Homo sapiens
47 SMARCA1 6594
Affinity Capture-MS Homo sapiens
48 PRC1 9055
Affinity Capture-MS Homo sapiens
49 C4orf27  
Reconstituted Complex Homo sapiens
50 MDC1  
Affinity Capture-MS Homo sapiens
51 HIST1H2AG 8969
Affinity Capture-MS Homo sapiens
52 POU5F1  
Affinity Capture-MS Homo sapiens
53 NPM1 4869
Far Western Homo sapiens
54 H2AFY2 55506
Affinity Capture-MS Homo sapiens
55 OBSL1 23363
Affinity Capture-MS Homo sapiens
56 EWSR1 2130
Two-hybrid Homo sapiens
57 MCM6 4175
Affinity Capture-MS Homo sapiens
58 THRAP3 9967
Affinity Capture-MS Homo sapiens
59 ORC6  
Reconstituted Complex Homo sapiens
60 ZNF644  
Affinity Capture-MS Homo sapiens
61 HMGA2 8091
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
62 CDC27 996
Affinity Capture-MS Homo sapiens
63 POU3F1  
Reconstituted Complex Homo sapiens
64 BCOR  
Affinity Capture-MS Homo sapiens
65 ANAPC7 51434
Affinity Capture-MS Homo sapiens
66 ATG16L1 55054
Affinity Capture-MS Homo sapiens
67 Gspt1 14852
Affinity Capture-MS Mus musculus
68 MECP2 4204
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 MYCN  
Affinity Capture-MS Homo sapiens
70 PARP2  
Affinity Capture-MS Homo sapiens
71 POGZ 23126
Affinity Capture-MS Homo sapiens
72 WDR5 11091
Affinity Capture-MS Homo sapiens
73 SMARCB1 6598
Affinity Capture-MS Homo sapiens
74 NEDD4 4734
Affinity Capture-MS Homo sapiens
75 MTA2 9219
Affinity Capture-MS Homo sapiens
76 RBM8A 9939
Affinity Capture-MS Homo sapiens
77 KIF14 9928
Affinity Capture-MS Homo sapiens
78 HIST3H2BB 128312
Cross-Linking-MS (XL-MS) Homo sapiens
79 GTF2I 2969
Cross-Linking-MS (XL-MS) Homo sapiens
80 POLE3  
Affinity Capture-MS Homo sapiens
81 E2F4  
Affinity Capture-MS Homo sapiens
82 HIST2H2AA3 8337
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
83 HTT 3064
Affinity Capture-Luminescence Homo sapiens
84 VRK3 51231
Affinity Capture-MS Homo sapiens
85 JMJD6 23210
Affinity Capture-MS Homo sapiens
86 RBBP7 5931
Affinity Capture-MS Homo sapiens
87 UBN2  
Affinity Capture-MS Homo sapiens
88 FOXA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 HIST2H2AB 317772
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 Klc4  
Two-hybrid Mus musculus
91 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 USP10 9100
Affinity Capture-MS Homo sapiens
93 TRIM58 25893
Affinity Capture-MS Homo sapiens
94 RFC5 5985
Affinity Capture-MS Homo sapiens
95 SMARCA5 8467
Affinity Capture-MS Homo sapiens
96 UBB 7314
Affinity Capture-MS Homo sapiens
97 WHSC1 7468
Affinity Capture-MS Homo sapiens
98 IRF1  
Reconstituted Complex Homo sapiens
99 WDR89  
Affinity Capture-MS Homo sapiens
100 RPS10 6204
Cross-Linking-MS (XL-MS) Homo sapiens
101 NCOR2  
Affinity Capture-Western Homo sapiens
102 MSX2  
Affinity Capture-MS Homo sapiens
103 DOT1L 84444
Cross-Linking-MS (XL-MS) Homo sapiens
104 NAA40  
Affinity Capture-MS Homo sapiens
105 ATF2  
Reconstituted Complex Homo sapiens
106 CBX3 11335
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 VRK1 7443
Affinity Capture-MS Homo sapiens
108 UBE2I 7329
Affinity Capture-Western Homo sapiens
109 ABCF2 10061
Cross-Linking-MS (XL-MS) Homo sapiens
110 Kifc1  
Affinity Capture-MS Mus musculus
111 IWS1  
Affinity Capture-MS Homo sapiens
112 SMARCA4 6597
Affinity Capture-MS Homo sapiens
113 Srp72  
Affinity Capture-MS Mus musculus
114 CHMP4B 128866
Affinity Capture-MS Homo sapiens
115 BTF3 689
Affinity Capture-MS Homo sapiens
116 BARD1 580
Affinity Capture-MS Homo sapiens
117 Stag2  
Affinity Capture-MS Mus musculus
118 ACTL6A 86
Affinity Capture-MS Homo sapiens
119 CBX5 23468
Affinity Capture-MS Homo sapiens
120 HIST1H1E 3008
Cross-Linking-MS (XL-MS) Homo sapiens
121 USP7 7874
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
122 HEMGN  
Two-hybrid Homo sapiens
123 BANF1 8815
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 HIST1H1C 3006
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
125 MB21D1  
Proximity Label-MS Homo sapiens
126 SAFB2 9667
Affinity Capture-MS Homo sapiens
127 SCOC 60592
Affinity Capture-MS Homo sapiens
128 CTR9 9646
Affinity Capture-MS Homo sapiens
129 MRPL11 65003
Proximity Label-MS Homo sapiens
130 POLB 5423
Affinity Capture-MS Homo sapiens
131 Ube2i  
Two-hybrid Mus musculus
132 HIST2H2BF 440689
Cross-Linking-MS (XL-MS) Homo sapiens
133 SCAF11  
Affinity Capture-MS Homo sapiens
134 ATG7 10533
Co-fractionation Homo sapiens
135 CEBPA  
Protein-peptide Homo sapiens
136 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
137 MED15  
Cross-Linking-MS (XL-MS) Homo sapiens
138 RAI1 10743
Affinity Capture-MS Homo sapiens
139 YWHAE 7531
Co-fractionation Homo sapiens
140 ZMYM4  
Affinity Capture-MS Homo sapiens
141 ANLN 54443
Affinity Capture-MS Homo sapiens
142 TPX2  
Affinity Capture-MS Homo sapiens
143 ASH2L 9070
Affinity Capture-MS Homo sapiens
144 NUMA1 4926
Affinity Capture-MS Homo sapiens
145 HIST1H2BL 8340
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
146 PER2  
Proximity Label-MS Homo sapiens
147 GOLGA3 2802
Cross-Linking-MS (XL-MS) Homo sapiens
148 HIST1H3A 8350
Proximity Label-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
149 FANCD2  
Affinity Capture-MS Homo sapiens
150 SMARCE1 6605
Affinity Capture-MS Homo sapiens
151 BAZ1B 9031
Affinity Capture-MS Homo sapiens
152 LMNB1 4001
Proximity Label-MS Homo sapiens
153 ECT2 1894
Affinity Capture-MS Homo sapiens
154 IKZF3  
Affinity Capture-MS Homo sapiens
155 RNF169  
Affinity Capture-MS Homo sapiens
156 PPARG 5468
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
157 RFC2 5982
Affinity Capture-MS Homo sapiens
158 HCFC1 3054
Affinity Capture-MS Homo sapiens
159 CD274 29126
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
160 PHIP 55023
Affinity Capture-MS Homo sapiens
161 CUL3 8452
Affinity Capture-MS Homo sapiens
162 PBRM1 55193
Affinity Capture-MS Homo sapiens
163 EGFR 1956
Affinity Capture-MS Homo sapiens
164 RPL24 6152
Cross-Linking-MS (XL-MS) Homo sapiens
165 H1F0 3005
Affinity Capture-MS Homo sapiens
166 MCM4 4173
Affinity Capture-MS Homo sapiens
167 IKZF1  
Affinity Capture-MS Homo sapiens
168 POLR2A 5430
Affinity Capture-MS Homo sapiens
169 SUZ12  
Affinity Capture-MS Homo sapiens
170 FN1 2335
Affinity Capture-MS Homo sapiens
171 HIST1H2BO 8348
Cross-Linking-MS (XL-MS) Homo sapiens
172 JUN 3725
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
173 C12orf65  
Proximity Label-MS Homo sapiens
174 CDK2 1017
Affinity Capture-MS Homo sapiens
175 ZSCAN5A  
Affinity Capture-MS Homo sapiens
176 LSM4 25804
Cross-Linking-MS (XL-MS) Homo sapiens
177 TNRC18  
Cross-Linking-MS (XL-MS) Homo sapiens
178 MYC  
Affinity Capture-MS Homo sapiens
179 HIST1H2BA 255626
Cross-Linking-MS (XL-MS) Homo sapiens
180 RUVBL2 10856
Affinity Capture-MS Homo sapiens
181 EMC2 9694
Affinity Capture-MS Homo sapiens
182 ING5  
Affinity Capture-MS Homo sapiens
183 TERF2  
Co-fractionation Homo sapiens
184 USP24 23358
Affinity Capture-MS Homo sapiens
185 EED  
Affinity Capture-MS Homo sapiens
186 NFKB1 4790
Reconstituted Complex Homo sapiens
187 KMT2A  
Cross-Linking-MS (XL-MS) Homo sapiens
188 PCGF1 84759
Affinity Capture-MS Homo sapiens
189 KAT6A  
Affinity Capture-MS Homo sapiens
190 FKBP3 2287
Affinity Capture-MS Homo sapiens
191 RNF2  
Affinity Capture-MS Homo sapiens
192 PYCR2 29920
Affinity Capture-MS Homo sapiens
193 POU2F2 5452
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
194 NFYA 4800
Far Western Homo sapiens
195 NANOG  
Affinity Capture-MS Homo sapiens
196 RBBP5 5929
Affinity Capture-MS Homo sapiens
197 HMG20A  
Affinity Capture-MS Homo sapiens
198 LIG3 3980
Affinity Capture-MS Homo sapiens
199 UPF2 26019
Two-hybrid Homo sapiens
200 HMGB1P1 10357
Affinity Capture-MS Homo sapiens
201 PHF14 9678
Affinity Capture-MS Homo sapiens
202 XRCC5 7520
Affinity Capture-MS Homo sapiens
203 NCDN 23154
Affinity Capture-MS Homo sapiens
204 CBX7  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
205 TXLNA 200081
Cross-Linking-MS (XL-MS) Homo sapiens
206 H2AFX 3014
Affinity Capture-MS Homo sapiens
207 CBX2  
Affinity Capture-MS Homo sapiens
208 RPS27A 6233
Cross-Linking-MS (XL-MS) Homo sapiens
209 RARA 5914
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
210 TSFM 10102
Proximity Label-MS Homo sapiens
211 PARP1 142
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
212 SUPT5H 6829
Affinity Capture-MS Homo sapiens
213 HIST1H2AC 8334
Affinity Capture-MS Homo sapiens
214 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
215 ARRDC5  
Affinity Capture-MS Homo sapiens
216 HIST1H2BB 3018
Cross-Linking-MS (XL-MS) Homo sapiens
217 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
218 FOLR1 2348
Affinity Capture-MS Homo sapiens
219 ICT1 3396
Proximity Label-MS Homo sapiens
220 Fbl 14113
Affinity Capture-MS Mus musculus
221 SRSF9 8683
Affinity Capture-MS Homo sapiens
222 SMARCC1 6599
Affinity Capture-MS Homo sapiens
223 KAT2B  
Biochemical Activity Homo sapiens
224 CHAMP1  
Affinity Capture-MS Homo sapiens
225 RIF1  
Affinity Capture-MS Homo sapiens
226 DPY30 84661
Affinity Capture-MS Homo sapiens
227 UBA52 7311
Cross-Linking-MS (XL-MS) Homo sapiens
228 ZNF512  
Affinity Capture-MS Homo sapiens
229 HIST1H2BN 8341
Cross-Linking-MS (XL-MS) Homo sapiens
230 PSIP1 11168
Affinity Capture-MS Homo sapiens
231 AHCTF1 25909
Affinity Capture-MS Homo sapiens
232 VPS35 55737
Affinity Capture-MS Homo sapiens
233 MTA1 9112
Affinity Capture-MS Homo sapiens
234 CREBBP  
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
235 HIST1H2BD 3017
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
236 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
237 CHD1 1105
Affinity Capture-Western Homo sapiens
238 CREB1  
Affinity Capture-MS Homo sapiens
239 H2AFY 9555
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
240 ZMYM3  
Affinity Capture-MS Homo sapiens
241 POU2F1 5451
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
242 ZNF280C  
Affinity Capture-MS Homo sapiens
243 COMMD3-BMI1 100532731
Affinity Capture-MS Homo sapiens
244 RBFOX2 23543
Two-hybrid Homo sapiens
245 LOC102724334 102724334
Cross-Linking-MS (XL-MS) Homo sapiens
246 TRIM37  
Proximity Label-MS Homo sapiens
247 LCOR 84458
Affinity Capture-MS Homo sapiens
248 EZH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
249 H2AFZ 3015
Affinity Capture-MS Homo sapiens
250 DDB1 1642
Affinity Capture-MS Homo sapiens
251 PRKCA 5578
Biochemical Activity Homo sapiens
252 TCF20  
Affinity Capture-MS Homo sapiens
253 AP4M1 9179
Affinity Capture-MS Homo sapiens
254 SARNP 84324
Cross-Linking-MS (XL-MS) Homo sapiens
255 GRSF1 2926
Proximity Label-MS Homo sapiens
256 C1QBP 708
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
257 CEBPB  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
258 INTS3 65123
Affinity Capture-MS Homo sapiens
259 HIRA  
Affinity Capture-MS Homo sapiens
260 CUL7 9820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
261 KRAS 3845
Negative Genetic Homo sapiens
262 UHRF1 29128
Affinity Capture-MS Homo sapiens
263 PHF10  
Affinity Capture-MS Homo sapiens
264 RSF1  
Affinity Capture-MS Homo sapiens
265 TRIM29 23650
Affinity Capture-MS Homo sapiens
266 PWWP2A  
Affinity Capture-MS Homo sapiens
267 RBBP4 5928
Affinity Capture-MS Homo sapiens
268 FOXE1  
Affinity Capture-MS Homo sapiens
269 CHD4 1108
Affinity Capture-MS Homo sapiens
270 RCOR1  
Affinity Capture-MS Homo sapiens
271 RN7SK 125050
Protein-RNA Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here