Gene description for PRKDC
Gene name protein kinase, DNA-activated, catalytic polypeptide
Gene symbol PRKDC
Other names/aliases DNA-PKcs
DNAPK
DNPK1
HYRC
HYRC1
IMD26
XRCC7
p350
Species Homo sapiens
 Database cross references - PRKDC
ExoCarta ExoCarta_5591
Vesiclepedia VP_5591
Entrez Gene 5591
HGNC 9413
MIM 600899
UniProt P78527  
 PRKDC identified in sEVs derived from the following tissue/cell type
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 17956143    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 36706192    
Embryonic kidney cells 36706192    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Neuroblastoma cells 25944692    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
T lymphocytes 34108659    
Thymus 23844026    
 Gene ontology annotations for PRKDC
Molecular Function
    double-stranded DNA binding GO:0003690 IDA
    RNA binding GO:0003723 HDA
    protein kinase activity GO:0004672 IDA
    protein kinase activity GO:0004672 IMP
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 TAS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IDA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    enzyme binding GO:0019899 IEA
    protein domain specific binding GO:0019904 IPI
    U3 snoRNA binding GO:0034511 IDA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IDA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    maturation of 5.8S rRNA GO:0000460 IDA
    telomere maintenance GO:0000723 IBA
    somitogenesis GO:0001756 IEA
    negative regulation of protein phosphorylation GO:0001933 ISS
    activation of innate immune response GO:0002218 IDA
    B cell lineage commitment GO:0002326 IEA
    immature B cell differentiation GO:0002327 IEA
    pro-B cell differentiation GO:0002328 IEA
    T cell lineage commitment GO:0002360 IEA
    double-strand break repair GO:0006302 IBA
    double-strand break repair GO:0006302 IMP
    double-strand break repair via nonhomologous end joining GO:0006303 NAS
    double-strand break repair via nonhomologous end joining GO:0006303 TAS
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IDA
    protein phosphorylation GO:0006468 IMP
    DNA damage response GO:0006974 IDA
    brain development GO:0007420 IEA
    heart development GO:0007507 IEA
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IBA
    response to gamma radiation GO:0010332 IEA
    telomere capping GO:0016233 IMP
    peptidyl-serine phosphorylation GO:0018105 IDA
    peptidyl-serine phosphorylation GO:0018105 IDA
    peptidyl-threonine phosphorylation GO:0018107 IDA
    mitotic G1 DNA damage checkpoint signaling GO:0031571 IMP
    protein destabilization GO:0031648 IEA
    cellular response to insulin stimulus GO:0032869 IMP
    T cell differentiation in thymus GO:0033077 IEA
    immunoglobulin V(D)J recombination GO:0033152 IBA
    T cell receptor V(D)J recombination GO:0033153 IEA
    small-subunit processome assembly GO:0034462 IDA
    ectopic germ cell programmed cell death GO:0035234 IEA
    protein modification process GO:0036211 TAS
    regulation of circadian rhythm GO:0042752 ISS
    positive regulation of apoptotic process GO:0043065 IEA
    negative regulation of apoptotic process GO:0043066 IMP
    innate immune response GO:0045087 IEA
    positive regulation of lymphocyte differentiation GO:0045621 ISS
    positive regulation of erythrocyte differentiation GO:0045648 ISS
    positive regulation of translation GO:0045727 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    rhythmic process GO:0048511 IEA
    regulation of smooth muscle cell proliferation GO:0048660 IMP
    regulation of epithelial cell proliferation GO:0050678 IMP
    double-strand break repair via alternative nonhomologous end joining GO:0097681 TAS
    negative regulation of cGAS/STING signaling pathway GO:0160049 IDA
    regulation of hematopoietic stem cell differentiation GO:1902036 ISS
    positive regulation of platelet formation GO:1905221 ISS
    positive regulation of double-strand break repair via nonhomologous end joining GO:2001034 IDA
Subcellular Localization
    chromosome, telomeric region GO:0000781 HDA
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IDA
    nucleolus GO:0005730 IDA
    cytosol GO:0005829 TAS
    DNA-dependent protein kinase-DNA ligase 4 complex GO:0005958 IDA
    membrane GO:0016020 HDA
    small-subunit processome GO:0032040 IDA
    protein-containing complex GO:0032991 IMP
    protein-DNA complex GO:0032993 IDA
    DNA-dependent protein kinase complex GO:0070418 IPI
    nonhomologous end joining complex GO:0070419 IDA
 Experiment description of studies that identified PRKDC in sEVs
1
Experiment ID 412
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
2
Experiment ID 414
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
3
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 494
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 498
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 20
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
10
Experiment ID 282
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
11
Experiment ID 283
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
12
Experiment ID 285
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Sequential centrifugal ultrafiltration - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Sequential centrifugal ultrafiltration
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
13
Experiment ID 286
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Sequential centrifugal ultrafiltration - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Sequential centrifugal ultrafiltration
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
14
Experiment ID 1203
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
15
Experiment ID 407
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
16
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
20
Experiment ID 1275
MISEV standards
Biophysical techniques
✔ Enriched markers
✔ Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 1280
MISEV standards
Biophysical techniques
✔ Enriched markers
✔ Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T - Fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density 1.151 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 405
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
23
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
24
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
25
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
26
Experiment ID 235
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
27
Experiment ID 417
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
28
Experiment ID 411
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
29
Experiment ID 254
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name MNT-1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
30
Experiment ID 255
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name G1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
31
Experiment ID 256
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 501mel
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
32
Experiment ID 257
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
33
Experiment ID 259
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
34
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
35
Experiment ID 418
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
36
Experiment ID 418
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
37
Experiment ID 219
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name C666-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
38
Experiment ID 220
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP69
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
39
Experiment ID 221
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP460
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
40
Experiment ID 224
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
41
Experiment ID 413
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
42
Experiment ID 211
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
43
Experiment ID 212
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
44
Experiment ID 406
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
45
Experiment ID 415
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
46
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
47
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
48
Experiment ID 408
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
49
Experiment ID 409
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
50
Experiment ID 416
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
51
Experiment ID 834
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
52
Experiment ID 835
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
53
Experiment ID 410
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
54
Experiment ID 217
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PRKDC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TACR3  
Affinity Capture-MS Homo sapiens
2 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
3 ADAM11 4185
Affinity Capture-MS Homo sapiens
4 ISG15 9636
Affinity Capture-MS Homo sapiens
5 ALOX15  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 SHC1 6464
Affinity Capture-MS Homo sapiens
7 Ruvbl1 56505
Affinity Capture-MS Mus musculus
8 PRPF8 10594
Co-fractionation Homo sapiens
9 SKI 6497
Affinity Capture-MS Homo sapiens
10 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 BRCA1 672
Protein-peptide Homo sapiens
12 MAP4 4134
Affinity Capture-MS Homo sapiens
13 KIF20A 10112
Affinity Capture-MS Homo sapiens
14 CSNK2A1 1457
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
15 VHL  
Negative Genetic Homo sapiens
16 NCF1  
Biochemical Activity Homo sapiens
17 PRKDC 5591
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
18 CENPA  
Affinity Capture-MS Homo sapiens
19 HDAC3 8841
Biochemical Activity Homo sapiens
20 WDR76  
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
21 DDA1  
Affinity Capture-MS Homo sapiens
22 DTX3  
Affinity Capture-MS Homo sapiens
23 C1D  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
24 CHAF1A  
Affinity Capture-MS Homo sapiens
25 KIF23 9493
Affinity Capture-MS Homo sapiens
26 PPP6C 5537
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
27 SF3B1 23451
Co-fractionation Homo sapiens
28 POU5F1  
Affinity Capture-MS Homo sapiens
29 PPEF1  
Affinity Capture-MS Homo sapiens
30 MECP2 4204
Affinity Capture-MS Homo sapiens
31 PPP6R3 55291
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
32 RPS11 6205
Co-fractionation Homo sapiens
33 MTA2 9219
Co-fractionation Homo sapiens
34 NEIL3  
Protein-RNA Homo sapiens
35 KIF14 9928
Affinity Capture-MS Homo sapiens
36 RBMX 27316
Co-fractionation Homo sapiens
37 XRCC4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
38 CHMP4C 92421
Affinity Capture-MS Homo sapiens
39 RNF4 6047
Affinity Capture-MS Homo sapiens
40 C19orf38  
Affinity Capture-MS Homo sapiens
41 CRY1  
Affinity Capture-MS Homo sapiens
42 MRE11A 4361
Protein-peptide Homo sapiens
43 PPP6R2 9701
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
44 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
45 UBAC2 337867
Affinity Capture-MS Homo sapiens
46 CDH1 999
Co-fractionation Homo sapiens
47 LRRFIP1 9208
Co-fractionation Homo sapiens
48 YAP1 10413
Affinity Capture-MS Homo sapiens
49 SLX4  
Affinity Capture-MS Homo sapiens
50 NOS2  
Affinity Capture-MS Homo sapiens
51 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
52 HECTD1 25831
Affinity Capture-MS Homo sapiens
53 MAPK8 5599
Biochemical Activity Homo sapiens
54 SEC61B 10952
Affinity Capture-MS Homo sapiens
55 METTL1 4234
Co-fractionation Homo sapiens
56 MGMT 4255
Affinity Capture-MS Homo sapiens
57 SCARNA22  
Affinity Capture-RNA Homo sapiens
58 ANLN 54443
Affinity Capture-MS Homo sapiens
59 PHLPP1  
Proximity Label-MS Homo sapiens
60 HSPA5 3309
Affinity Capture-MS Homo sapiens
61 AHSA1 10598
Affinity Capture-Western Homo sapiens
62 EIF2S1 1965
Co-fractionation Homo sapiens
63 SIRT7  
Affinity Capture-MS Homo sapiens
64 EPAS1  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
65 Terf1  
Affinity Capture-MS Mus musculus
66 IQCB1  
Affinity Capture-MS Homo sapiens
67 CD274 29126
Affinity Capture-MS Homo sapiens
68 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 FKBP8 23770
Affinity Capture-MS Homo sapiens
70 ATRIP  
Reconstituted Complex Homo sapiens
71 PHKG2 5261
Affinity Capture-MS Homo sapiens
72 EIF2S2 8894
Co-fractionation Homo sapiens
Co-purification Homo sapiens
73 FN1 2335
Affinity Capture-MS Homo sapiens
74 THRA  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
75 PCBP1 5093
Proximity Label-MS Homo sapiens
76 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
77 NUCB1 4924
Co-fractionation Homo sapiens
78 DLST 1743
Co-fractionation Homo sapiens
79 HIST1H1A 3024
Biochemical Activity Homo sapiens
80 ILK 3611
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 PRKAB2 5565
Affinity Capture-MS Homo sapiens
82 AKT1 207
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Negative Genetic Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
83 NFATC2  
Affinity Capture-MS Homo sapiens
84 SUPT16H 11198
Affinity Capture-MS Homo sapiens
85 BIRC5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
86 GBAS 2631
Affinity Capture-MS Homo sapiens
87 MAGEA8  
Affinity Capture-MS Homo sapiens
88 RELA 5970
Affinity Capture-MS Homo sapiens
89 GRK5 2869
Affinity Capture-MS Homo sapiens
90 KAT8  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
91 IGHD  
Affinity Capture-MS Homo sapiens
92 EIF3I 8668
Cross-Linking-MS (XL-MS) Homo sapiens
93 RUVBL2 10856
Affinity Capture-MS Homo sapiens
94 ZEB1  
Affinity Capture-MS Homo sapiens
95 DFFA 1676
Co-fractionation Homo sapiens
96 RBM25 58517
Co-fractionation Homo sapiens
97 CHRM4  
Affinity Capture-MS Homo sapiens
98 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
99 TRA2B 6434
Co-fractionation Homo sapiens
100 Ppp6r1  
Affinity Capture-MS Mus musculus
101 CDK4 1019
Negative Genetic Homo sapiens
102 RAD21 5885
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
103 PTGES3 10728
Affinity Capture-MS Homo sapiens
104 SNW1 22938
Affinity Capture-MS Homo sapiens
105 SNRPA1 6627
Co-fractionation Homo sapiens
106 ATR  
Co-localization Homo sapiens
107 LIG4 3981
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
108 NCOA6  
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
109 SPRTN  
Affinity Capture-MS Homo sapiens
110 EIF2S3 1968
Co-fractionation Homo sapiens
111 RPA2 6118
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
112 VPRBP 9730
Biochemical Activity Homo sapiens
113 ADRB2  
Affinity Capture-MS Homo sapiens
114 XPA  
Biochemical Activity Homo sapiens
115 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
116 ATM 472
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
117 CREM  
Affinity Capture-MS Homo sapiens
118 XRCC1 7515
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
119 NR1H4  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
120 NCOR1  
Cross-Linking-MS (XL-MS) Homo sapiens
121 B3GNT2 10678
Affinity Capture-MS Homo sapiens
122 DIAPH1 1729
Co-fractionation Homo sapiens
123 NUCKS1 64710
Affinity Capture-MS Homo sapiens
124 FZR1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
125 PRC1 9055
Affinity Capture-MS Homo sapiens
126 NPM1 4869
Co-fractionation Homo sapiens
127 PPP6R1 22870
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
128 PTER 9317
Co-fractionation Homo sapiens
129 OBSL1 23363
Affinity Capture-MS Homo sapiens
130 TINF2  
Affinity Capture-MS Homo sapiens
131 MBP 4155
Biochemical Activity Homo sapiens
132 ITFG3 83986
Affinity Capture-MS Homo sapiens
133 DNAJC7 7266
Affinity Capture-MS Homo sapiens
134 VCAM1 7412
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 E4F1  
Protein-peptide Homo sapiens
136 CUL1 8454
Affinity Capture-MS Homo sapiens
137 AKTIP  
Affinity Capture-Western Homo sapiens
138 GSK3B 2932
Biochemical Activity Homo sapiens
139 GTF2I 2969
Co-fractionation Homo sapiens
140 GZMB  
Biochemical Activity Homo sapiens
141 YBX1 4904
Co-fractionation Homo sapiens
142 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
143 CTDP1 9150
Biochemical Activity Homo sapiens
Protein-peptide Homo sapiens
144 LYN 4067
Reconstituted Complex Homo sapiens
145 NBN 4683
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
146 VRK1 7443
Affinity Capture-MS Homo sapiens
147 CCNB1 891
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
148 PBXIP1 57326
Affinity Capture-MS Homo sapiens
149 PLK1 5347
Affinity Capture-MS Homo sapiens
150 PPP2CA 5515
Affinity Capture-Western Homo sapiens
151 Bag2  
Affinity Capture-MS Mus musculus
152 ARHGEF6 9459
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
153 DCLRE1B  
Affinity Capture-MS Homo sapiens
154 NCF4 4689
Biochemical Activity Homo sapiens
155 CYLD  
Affinity Capture-MS Homo sapiens
156 UBXN6 80700
Affinity Capture-MS Homo sapiens
157 MLNR  
Affinity Capture-MS Homo sapiens
158 KDF1  
Affinity Capture-MS Homo sapiens
159 RECQL5  
Affinity Capture-MS Homo sapiens
160 SLC15A1  
Affinity Capture-MS Homo sapiens
161 CLN3 1201
Affinity Capture-MS Homo sapiens
162 SMARCAD1  
Affinity Capture-MS Homo sapiens
163 ILKAP 80895
Cross-Linking-MS (XL-MS) Homo sapiens
164 PTH2R  
Affinity Capture-MS Homo sapiens
165 MEX3A  
Affinity Capture-RNA Homo sapiens
166 RASSF1  
Protein-peptide Homo sapiens
167 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
168 FUS 2521
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
169 RIPK4  
Affinity Capture-MS Homo sapiens
170 EFTUD2 9343
Co-fractionation Homo sapiens
171 CDK2 1017
Affinity Capture-MS Homo sapiens
172 MYC  
Affinity Capture-MS Homo sapiens
Synthetic Lethality Homo sapiens
Affinity Capture-MS Homo sapiens
173 SERBP1 26135
Affinity Capture-MS Homo sapiens
174 PDX1  
Biochemical Activity Homo sapiens
175 Them6  
Affinity Capture-MS Mus musculus
176 SAP25  
Affinity Capture-MS Homo sapiens
177 CUL7 9820
Affinity Capture-MS Homo sapiens
178 DDRGK1 65992
Affinity Capture-MS Homo sapiens
179 Yap1  
Reconstituted Complex Mus musculus
180 BMI1  
Affinity Capture-Western Homo sapiens
181 NFYA 4800
Co-fractionation Homo sapiens
182 LMNA 4000
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
183 HUWE1 10075
Affinity Capture-MS Homo sapiens
184 PHGDH 26227
Co-fractionation Homo sapiens
185 DSP 1832
Cross-Linking-MS (XL-MS) Homo sapiens
186 MAS1  
Affinity Capture-MS Homo sapiens
187 Ruvbl2 20174
Affinity Capture-MS Mus musculus
188 PARP1 142
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
189 HDGF 3068
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
190 ATXN3 4287
Affinity Capture-MS Homo sapiens
191 H3F3A 3020
Affinity Capture-MS Homo sapiens
192 TP53 7157
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
193 MKNK1  
Two-hybrid Homo sapiens
194 SSRP1 6749
Affinity Capture-MS Homo sapiens
195 HDAC6 10013
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
196 RYK 6259
Affinity Capture-MS Homo sapiens
197 ATG101  
Affinity Capture-MS Homo sapiens
198 MLH1 4292
Affinity Capture-MS Homo sapiens
199 PRKACA 5566
Affinity Capture-MS Homo sapiens
200 POU2F1 5451
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
201 ESR1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
202 AUP1 550
Affinity Capture-MS Homo sapiens
203 HEXIM1 10614
Co-fractionation Homo sapiens
204 BCL2L1 598
Affinity Capture-MS Homo sapiens
205 DHX38 9785
Co-fractionation Homo sapiens
206 C16orf72 29035
Affinity Capture-MS Homo sapiens
207 YBX3 8531
Co-fractionation Homo sapiens
208 PRDX1 5052
Co-fractionation Homo sapiens
209 KIR2DL4  
Affinity Capture-MS Homo sapiens
210 LPAR4  
Affinity Capture-MS Homo sapiens
211 VASN 114990
Affinity Capture-MS Homo sapiens
212 ATOH1  
Affinity Capture-MS Homo sapiens
213 IKBKB 3551
Biochemical Activity Homo sapiens
214 PRMT1 3276
Affinity Capture-MS Homo sapiens
215 ZBTB7A 51341
Affinity Capture-MS Homo sapiens
216 RANBP2 5903
Co-fractionation Homo sapiens
217 HNRNPC 3183
Biochemical Activity Homo sapiens
218 THRB 7068
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
219 CTPS2 56474
Co-fractionation Homo sapiens
220 SP1  
Biochemical Activity Homo sapiens
221 PGR  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
222 AKT2 208
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
223 TRIM28 10155
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
224 MCM2 4171
Affinity Capture-MS Homo sapiens
225 CASP3 836
Biochemical Activity Homo sapiens
226 HLA-B 3106
Affinity Capture-MS Homo sapiens
227 PNKP 11284
Affinity Capture-MS Homo sapiens
228 TELO2 9894
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
229 MDC1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
230 SRP14 6727
Co-fractionation Homo sapiens
231 EPHA1 2041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
232 ITGA4 3676
Affinity Capture-MS Homo sapiens
233 ATRX 546
Affinity Capture-MS Homo sapiens
234 CALR 811
Co-fractionation Homo sapiens
235 TFCP2 7024
Affinity Capture-MS Homo sapiens
236 IL13RA2 3598
Affinity Capture-MS Homo sapiens
237 EHD1 10938
Co-fractionation Homo sapiens
238 MSL3  
Affinity Capture-Western Homo sapiens
239 Cebpb  
Affinity Capture-Western Rattus norvegicus
240 HSPA8 3312
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
241 MTNR1B  
Two-hybrid Homo sapiens
242 MYO18A 399687
Cross-Linking-MS (XL-MS) Homo sapiens
243 FOXC1  
Affinity Capture-MS Homo sapiens
244 PARK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
245 IGF1R 3480
Negative Genetic Homo sapiens
246 COPE 11316
Affinity Capture-MS Homo sapiens
247 MEX3C 51320
Affinity Capture-MS Homo sapiens
248 CHMP4B 128866
Affinity Capture-MS Homo sapiens
249 BTF3 689
Affinity Capture-MS Homo sapiens
250 NTRK1 4914
Affinity Capture-MS Homo sapiens
251 GPR182  
Affinity Capture-MS Homo sapiens
252 ARNT 405
Co-localization Homo sapiens
253 CIB1 10519
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
254 DHX9 1660
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
255 HDAC5 10014
Affinity Capture-MS Homo sapiens
256 ASB5  
Affinity Capture-MS Homo sapiens
257 EFNA4  
Affinity Capture-MS Homo sapiens
258 TNFAIP8L1  
Affinity Capture-MS Homo sapiens
259 CDC73  
Affinity Capture-MS Homo sapiens
260 ECT2 1894
Affinity Capture-MS Homo sapiens
261 FAM60A  
Affinity Capture-MS Homo sapiens
262 U2AF2 11338
Co-fractionation Homo sapiens
263 MGARP  
Affinity Capture-MS Homo sapiens
264 NR3C1 2908
Biochemical Activity Homo sapiens
265 NPY2R  
Affinity Capture-MS Homo sapiens
266 YY1 7528
Co-purification Homo sapiens
267 FBXO6 26270
Affinity Capture-MS Homo sapiens
268 AP2M1 1173
Affinity Capture-MS Homo sapiens
269 RRM2 6241
Negative Genetic Homo sapiens
270 C3orf18  
Affinity Capture-MS Homo sapiens
271 YWHAQ 10971
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
272 MTOR 2475
Negative Genetic Homo sapiens
273 TOP1 7150
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
274 SLC22A15  
Affinity Capture-MS Homo sapiens
275 MATR3 9782
Co-fractionation Homo sapiens
276 HDLBP 3069
Affinity Capture-Western Homo sapiens
277 FLII 2314
Co-fractionation Homo sapiens
278 CHUK 1147
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
279 ILF3 3609
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
280 XRCC5 7520
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
281 RBBP8  
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
282 HIF1A 3091
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
283 DZIP3  
Affinity Capture-MS Homo sapiens
284 CRLF2 64109
Affinity Capture-MS Homo sapiens
285 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
286 JUP 3728
Co-fractionation Homo sapiens
287 FBXL6  
Affinity Capture-MS Homo sapiens
288 CWC27 10283
Co-fractionation Homo sapiens
289 OPALIN  
Affinity Capture-MS Homo sapiens
290 RPA1 6117
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
291 IKBKG 8517
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
292 SNRPA 6626
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
293 PIDD1  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
294 AICDA  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
295 ABL1 25
Reconstituted Complex Homo sapiens
296 CHD1L 9557
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
297 THOC6 79228
Co-fractionation Homo sapiens
298 GPRC5D  
Affinity Capture-MS Homo sapiens
299 PCNA 5111
Affinity Capture-MS Homo sapiens
300 UFL1 23376
Affinity Capture-MS Homo sapiens
301 NFYB  
Co-fractionation Homo sapiens
302 LRRK2 120892
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
303 RTCB 51493
Co-fractionation Homo sapiens
304 METTL3  
Affinity Capture-MS Homo sapiens
305 C14orf166 51637
Co-fractionation Homo sapiens
306 ERG  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
307 AR 367
Affinity Capture-MS Homo sapiens
308 UBA6 55236
Co-fractionation Homo sapiens
309 VIM 7431
Co-fractionation Homo sapiens
310 NOTCH1 4851
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
311 EP300 2033
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
312 UBE2H 7328
Affinity Capture-MS Homo sapiens
313 LGR4 55366
Affinity Capture-MS Homo sapiens
314 POT1  
Affinity Capture-MS Homo sapiens
315 MSH6 2956
Affinity Capture-Western Homo sapiens
316 USP5 8078
Co-fractionation Homo sapiens
317 KLRK1  
Affinity Capture-MS Homo sapiens
318 FPR1  
Affinity Capture-MS Homo sapiens
319 ANKRD28 23243
Affinity Capture-MS Homo sapiens
320 ATG4C  
Affinity Capture-MS Homo sapiens
321 TMPO 7112
Affinity Capture-MS Homo sapiens
322 ILF2 3608
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
323 GSK3A 2931
Biochemical Activity Homo sapiens
324 USP36  
Affinity Capture-MS Homo sapiens
325 USP18  
Affinity Capture-MS Homo sapiens
326 SRP54 6729
Co-fractionation Homo sapiens
327 TOP2A 7153
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
328 TGFB1 7040
Affinity Capture-MS Homo sapiens
329 COPS5 10987
Affinity Capture-MS Homo sapiens
330 FBXW7  
Affinity Capture-MS Homo sapiens
331 RPL24 6152
Cross-Linking-MS (XL-MS) Homo sapiens
332 HMGA1 3159
Affinity Capture-MS Homo sapiens
333 DGCR2 9993
Affinity Capture-MS Homo sapiens
334 PMS2  
Affinity Capture-MS Homo sapiens
335 METTL14  
Affinity Capture-MS Homo sapiens
336 MYCN  
Affinity Capture-MS Homo sapiens
337 FAF2 23197
Affinity Capture-MS Homo sapiens
338 GPR17 2840
Affinity Capture-MS Homo sapiens
339 TPT1 7178
Co-fractionation Homo sapiens
340 WRN 7486
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
341 USP22 23326
Affinity Capture-MS Homo sapiens
342 H2AFZ 3015
Affinity Capture-MS Homo sapiens
343 CHRM3 1131
Affinity Capture-MS Homo sapiens
344 RNF144A  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
345 NHEJ1  
Biochemical Activity Homo sapiens
346 EMD 2010
Affinity Capture-MS Homo sapiens
347 SMARCA5 8467
Co-fractionation Homo sapiens
348 CLSTN1 22883
Affinity Capture-MS Homo sapiens
349 Ppp6c 67857
Affinity Capture-MS Mus musculus
350 STAU1 6780
Affinity Capture-MS Homo sapiens
351 LRRC25  
Affinity Capture-MS Homo sapiens
352 TERF1 7013
Affinity Capture-Western Homo sapiens
353 UBE2I 7329
Biochemical Activity Homo sapiens
354 DDX5 1655
Co-fractionation Homo sapiens
355 ACTL6A 86
Co-fractionation Homo sapiens
356 CHEK1  
Reconstituted Complex Homo sapiens
Negative Genetic Homo sapiens
Protein-peptide Homo sapiens
357 SUMO2 6613
Reconstituted Complex Homo sapiens
358 AP1B1 162
Protein-peptide Homo sapiens
359 SRF  
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
360 SF3B6 51639
Co-fractionation Homo sapiens
361 CRY2  
Affinity Capture-MS Homo sapiens
362 EED  
Affinity Capture-MS Homo sapiens
363 CAMKK2 10645
Affinity Capture-MS Homo sapiens
364 CEBPA  
Protein-peptide Homo sapiens
365 PRKACB 5567
Affinity Capture-MS Homo sapiens
366 BAG3 9531
Affinity Capture-MS Homo sapiens
367 TPR 7175
Co-fractionation Homo sapiens
368 TTI1 9675
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
369 AIRE  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
370 HIST1H3A 8350
Co-localization Homo sapiens
371 FANCD2  
Affinity Capture-MS Homo sapiens
Synthetic Lethality Homo sapiens
372 PLRG1 5356
Co-fractionation Homo sapiens
373 CTNNB1 1499
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
374 RFC2 5982
Co-fractionation Homo sapiens
375 THYN1 29087
Co-fractionation Homo sapiens
376 HOXB7 3217
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
377 DCLRE1C  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
378 AURKB 9212
Affinity Capture-MS Homo sapiens
379 JUN 3725
Biochemical Activity Homo sapiens
380 SETD1A 9739
Affinity Capture-MS Homo sapiens
381 FKBP5 2289
Affinity Capture-MS Homo sapiens
382 HNRNPA1 3178
Biochemical Activity Homo sapiens
383 KAT5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
384 SRSF10 10772
Co-fractionation Homo sapiens
385 P2RY10  
Affinity Capture-MS Homo sapiens
386 CCDC8  
Affinity Capture-MS Homo sapiens
387 H2AFX 3014
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
388 IKBKAP 8518
Affinity Capture-MS Homo sapiens
389 SIRT6  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
390 BKRF1  
Affinity Capture-MS
391 KAT2A  
Biochemical Activity Homo sapiens
392 FOXRED2  
Affinity Capture-MS Homo sapiens
393 RAD17  
Protein-peptide Homo sapiens
394 DNAJA2 10294
Co-fractionation Homo sapiens
395 ZNF746  
Affinity Capture-MS Homo sapiens
396 TPTE  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
397 CUL5 8065
Affinity Capture-MS Homo sapiens
398 DGCR8  
Affinity Capture-MS Homo sapiens
399 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
400 HIST1H1A  
Biochemical Activity Bos taurus
401 NCF2 4688
Biochemical Activity Homo sapiens
402 ANAPC2 29882
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
403 CD80 941
Affinity Capture-MS Homo sapiens
404 KIAA1429 25962
Affinity Capture-MS Homo sapiens
405 TTI2 80185
Affinity Capture-MS Homo sapiens
406 BECN1 8678
Affinity Capture-MS Homo sapiens
407 MAPK9 5601
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
408 HSF1  
Reconstituted Complex Homo sapiens
409 CDK9 1025
Negative Genetic Homo sapiens
410 PINK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
411 XRCC6 2547
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
412 EIF5A 1984
Cross-Linking-MS (XL-MS) Homo sapiens
413 DRD4  
Affinity Capture-MS Homo sapiens
414 C9orf72  
Affinity Capture-MS Homo sapiens
415 USF1  
Affinity Capture-Western Homo sapiens
416 CDC5L 988
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
417 MTTP 4547
Cross-Linking-MS (XL-MS) Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here