Gene description for ABL1
Gene name	ABL proto-oncogene 1, non-receptor tyrosine kinase
Gene symbol	ABL1
Other names/aliases	ABL JTK7 bcr/abl c-ABL c-ABL1 p150 v-abl
Species	Homo sapiens
Database cross references - ABL1
ExoCarta	ExoCarta_25
Vesiclepedia	VP_25
Entrez Gene	25
HGNC	76
MIM	189980
UniProt	P00519
ABL1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocytes	26054723

Gene ontology annotations for ABL1

Molecular Function     magnesium ion binding GO:0000287 IDA     four-way junction DNA binding GO:0000400 IDA     bubble DNA binding GO:0000405 IDA     phosphotyrosine residue binding GO:0001784 IPI     DNA binding GO:0003677 NAS     transcription coactivator activity GO:0003713 TAS     actin monomer binding GO:0003785 TAS     nicotinate-nucleotide adenylyltransferase activity GO:0004515 TAS     protein kinase activity GO:0004672 IDA     protein kinase activity GO:0004672 IMP     protein tyrosine kinase activity GO:0004713 EXP     protein tyrosine kinase activity GO:0004713 IBA     protein tyrosine kinase activity GO:0004713 IDA     protein tyrosine kinase activity GO:0004713 IMP     protein tyrosine kinase activity GO:0004713 TAS     non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA     non-membrane spanning protein tyrosine kinase activity GO:0004715 IMP     protein kinase C binding GO:0005080 IPI     protein binding GO:0005515 IPI     ATP binding GO:0005524 IDA     kinase activity GO:0016301 IMP     SH3 domain binding GO:0017124 IPI     syntaxin binding GO:0019905 IPI     manganese ion binding GO:0030145 IDA     histone H3Y41 kinase activity GO:0035401 IEA     neuropilin binding GO:0038191 IPI     SH2 domain binding GO:0042169 IPI     ephrin receptor binding GO:0046875 ISS     actin filament binding GO:0051015 IEA     mitogen-activated protein kinase binding GO:0051019 IPI     proline-rich region binding GO:0070064 IDA     proline-rich region binding GO:0070064 IPI     delta-catenin binding GO:0070097 IEA     supercoiled DNA binding GO:0097100 IDA     histone H2AXY142 kinase activity GO:0140801 IEA     sequence-specific double-stranded DNA binding GO:1990837 IDA Biological Process     mitotic cell cycle GO:0000278 TAS     neural tube closure GO:0001843 IEA     B-1 B cell homeostasis GO:0001922 IEA     positive regulation of protein phosphorylation GO:0001934 IMP     B cell proliferation involved in immune response GO:0002322 IEA     transitional one stage B cell differentiation GO:0002333 IEA     mismatch repair GO:0006298 TAS     chromatin remodeling GO:0006338 IEA     regulation of DNA-templated transcription GO:0006355 TAS     autophagy GO:0006914 IEA     DNA damage response GO:0006974 IDA     response to oxidative stress GO:0006979 IGI     epidermal growth factor receptor signaling pathway GO:0007173 IBA     positive regulation of cytosolic calcium ion concentration GO:0007204 IMP     integrin-mediated signaling pathway GO:0007229 IBA     integrin-mediated signaling pathway GO:0007229 IMP     canonical NF-kappaB signal transduction GO:0007249 IEA     associative learning GO:0008306 IEA     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 TAS     response to xenobiotic stimulus GO:0009410 IEA     post-embryonic development GO:0009791 IEA     regulation of autophagy GO:0010506 TAS     positive regulation of endothelial cell migration GO:0010595 IBA     positive regulation of endothelial cell migration GO:0010595 IMP     peptidyl-tyrosine phosphorylation GO:0018108 IDA     peptidyl-tyrosine phosphorylation GO:0018108 IMP     peptidyl-tyrosine phosphorylation GO:0018108 TAS     cerebellum morphogenesis GO:0021587 IEA     negative regulation of cell-cell adhesion GO:0022408 IEA     microspike assembly GO:0030035 IEA     actin cytoskeleton organization GO:0030036 ISS     actin filament polymerization GO:0030041 IEA     regulation of endocytosis GO:0030100 TAS     regulation of cell adhesion GO:0030155 TAS     neuron differentiation GO:0030182 IEA     BMP signaling pathway GO:0030509 IEA     negative regulation of BMP signaling pathway GO:0030514 IEA     regulation of axon extension GO:0030516 IMP     phospholipase C-inhibiting G protein-coupled receptor signaling pathway GO:0030845 IMP     regulation of microtubule polymerization GO:0031113 IMP     regulation of Cdc42 protein signal transduction GO:0032489 IMP     positive regulation of type II interferon production GO:0032729 IEA     positive regulation of interleukin-2 production GO:0032743 IEA     regulation of actin cytoskeleton organization GO:0032956 IMP     regulation of actin cytoskeleton organization GO:0032956 TAS     positive regulation of osteoblast proliferation GO:0033690 IEA     substrate adhesion-dependent cell spreading GO:0034446 IEA     cellular response to oxidative stress GO:0034599 TAS     response to endoplasmic reticulum stress GO:0034976 IEA     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IMP     protein modification process GO:0036211 NAS     peptidyl-tyrosine autophosphorylation GO:0038083 IMP     Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS     neuropilin signaling pathway GO:0038189 IMP     signal transduction in response to DNA damage GO:0042770 IDA     positive regulation of apoptotic process GO:0043065 IDA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA     positive regulation of neuron apoptotic process GO:0043525 IEA     endothelial cell migration GO:0043542 IMP     regulation of T cell differentiation GO:0045580 ISS     positive regulation of vasoconstriction GO:0045907 IEA     negative regulation of mitotic cell cycle GO:0045930 IEA     positive regulation of mitotic cell cycle GO:0045931 IEA     positive regulation of transcription by RNA polymerase II GO:0045944 TAS     alpha-beta T cell differentiation GO:0046632 IEA     protein autophosphorylation GO:0046777 IDA     positive regulation of fibroblast proliferation GO:0048146 IEA     spleen development GO:0048536 IEA     thymus development GO:0048538 IEA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     activated T cell proliferation GO:0050798 IEA     T cell receptor signaling pathway GO:0050852 IEA     B cell receptor signaling pathway GO:0050853 IEA     neuromuscular process controlling balance GO:0050885 IEA     positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IEA     positive regulation of oxidoreductase activity GO:0051353 IDA     neuron apoptotic process GO:0051402 IEA     negative regulation of ubiquitin-protein transferase activity GO:0051444 IDA     negative regulation of ubiquitin-protein transferase activity GO:0051444 TAS     myoblast proliferation GO:0051450 IEA     positive regulation of stress fiber assembly GO:0051496 IMP     establishment of localization in cell GO:0051649 IEA     regulation of cell cycle GO:0051726 TAS     mitochondrial depolarization GO:0051882 TAS     positive regulation of focal adhesion assembly GO:0051894 IMP     Bergmann glial cell differentiation GO:0060020 IEA     cardiac muscle cell proliferation GO:0060038 IEA     neuroepithelial cell differentiation GO:0060563 IEA     cellular response to hydrogen peroxide GO:0070301 IDA     ERK1 and ERK2 cascade GO:0070371 IEA     negative regulation of ERK1 and ERK2 cascade GO:0070373 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     DNA conformation change GO:0071103 IDA     cellular response to lipopolysaccharide GO:0071222 IEA     cellular response to transforming growth factor beta stimulus GO:0071560 IEA     response to epinephrine GO:0071871 IEA     negative regulation of protein serine/threonine kinase activity GO:0071901 IDA     positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 IEA     cellular senescence GO:0090398 IEA     cell-cell adhesion GO:0098609 IEA     regulation of postsynaptic specialization assembly GO:0099150 IEA     positive regulation of dendrite development GO:1900006 IEA     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IMP     negative regulation of long-term synaptic potentiation GO:1900272 ISS     regulation of hematopoietic stem cell differentiation GO:1902036 TAS     positive regulation of extracellular matrix organization GO:1903055 IEA     podocyte apoptotic process GO:1903210 IEA     cellular response to dopamine GO:1903351 TAS     positive regulation of establishment of T cell polarity GO:1903905 ISS     DN4 thymocyte differentiation GO:1904157 IEA     protein localization to cytoplasmic microtubule plus-end GO:1904518 IMP     positive regulation of microtubule binding GO:1904528 IMP     positive regulation of actin filament binding GO:1904531 IMP     regulation of modification of synaptic structure GO:1905244 ISS     positive regulation of blood vessel branching GO:1905555 IEA     activation of protein kinase C activity GO:1990051 IDA     negative regulation of double-strand break repair via homologous recombination GO:2000042 IDA     positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 IEA     regulation of cell motility GO:2000145 TAS     negative regulation of endothelial cell apoptotic process GO:2000352 IEA     positive regulation of T cell migration GO:2000406 ISS     negative regulation of cellular senescence GO:2000773 IEA Subcellular Localization     ruffle GO:0001726 IEA     nucleus GO:0005634 IDA     nucleus GO:0005634 ISS     nucleus GO:0005634 NAS     nucleus GO:0005634 TAS     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     nucleolus GO:0005730 IDA     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 TAS     mitochondrion GO:0005739 NAS     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IBA     postsynaptic density GO:0014069 IEA     actin cytoskeleton GO:0015629 TAS     nuclear body GO:0016604 IDA     dendrite GO:0030425 ISS     growth cone GO:0030426 IEA     nuclear membrane GO:0031965 IEA     protein-containing complex GO:0032991 IPI     neuronal cell body GO:0043025 ISS     perinuclear region of cytoplasm GO:0048471 IDA     postsynapse GO:0098794 TAS     glutamatergic synapse GO:0098978 IEA