Gene description for BCR
Gene name breakpoint cluster region
Gene symbol BCR
Other names/aliases ALL
BCR1
CML
D22S11
D22S662
PHL
Species Homo sapiens
 Database cross references - BCR
ExoCarta ExoCarta_613
Vesiclepedia VP_613
Entrez Gene 613
HGNC 1014
MIM 151410
UniProt P11274  
 BCR identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Urine 19056867    
 Gene ontology annotations for BCR
Molecular Function
    protein serine/threonine kinase activity GO:0004674 TAS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein tyrosine kinase activity GO:0004713 TAS
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
    guanyl-nucleotide exchange factor activity GO:0005085 IMP
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    GTPase activator activity GO:0005096 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    negative regulation of cellular extravasation GO:0002692 IEA
    renal system process GO:0003014 IEA
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 TAS
    phagocytosis GO:0006909 IEA
    signal transduction GO:0007165 TAS
    small GTPase-mediated signal transduction GO:0007264 IMP
    brain development GO:0007420 IEA
    actin cytoskeleton organization GO:0030036 IEA
    keratinocyte differentiation GO:0030216 IMP
    regulation of Rho protein signal transduction GO:0035023 IMP
    inner ear morphogenesis GO:0042472 IEA
    regulation of vascular permeability GO:0043114 IEA
    neutrophil degranulation GO:0043312 IEA
    negative regulation of neutrophil degranulation GO:0043314 IEA
    focal adhesion assembly GO:0048041 IMP
    homeostasis of number of cells GO:0048872 IEA
    negative regulation of inflammatory response GO:0050728 IEA
    positive regulation of phagocytosis GO:0050766 IEA
    modulation of chemical synaptic transmission GO:0050804 ISS
    neuromuscular process controlling balance GO:0050885 IEA
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    regulation of cell cycle GO:0051726 IEA
    definitive hemopoiesis GO:0060216 IEA
    negative regulation of respiratory burst GO:0060268 IEA
    negative regulation of blood vessel remodeling GO:0060313 IEA
    intracellular protein transmembrane transport GO:0065002 IEA
    cellular response to lipopolysaccharide GO:0071222 IEA
    activation of GTPase activity GO:0090630 IDA
    activation of GTPase activity GO:0090630 IMP
    macrophage migration GO:1905517 IEA
    negative regulation of macrophage migration GO:1905522 IEA
    negative regulation of reactive oxygen species metabolic process GO:2000378 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IEA
    postsynaptic density GO:0014069 IEA
    membrane GO:0016020 HDA
    membrane GO:0016020 IBA
    axon GO:0030424 IEA
    protein-containing complex GO:0032991 IDA
    dendritic spine GO:0043197 IEA
    extracellular exosome GO:0070062 HDA
    Schaffer collateral - CA1 synapse GO:0098685 ISS
    glutamatergic synapse GO:0098978 ISS
 Experiment description of studies that identified BCR in sEVs
1
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for BCR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GRAP2 9402
Affinity Capture-MS Homo sapiens
2 AP2B1 163
Proximity Label-MS Homo sapiens
3 SHC1 6464
Affinity Capture-MS Homo sapiens
4 YWHAE 7531
Affinity Capture-MS Homo sapiens
5 CRK 1398
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
6 HOXA9  
Phenotypic Enhancement Homo sapiens
7 TRIM66  
Affinity Capture-MS Homo sapiens
8 SOS1 6654
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 CCDC183  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TSG101 7251
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
11 UBC 7316
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
12 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SPAG9 9043
Affinity Capture-MS Homo sapiens
14 IL3 3562
Affinity Capture-Western Homo sapiens
15 WDR48 57599
Affinity Capture-MS Homo sapiens
16 RDX 5962
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 MLLT4 4301
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Biochemical Activity Homo sapiens
18 MCM2 4171
Affinity Capture-MS Homo sapiens
19 AP2A1 160
Affinity Capture-MS Homo sapiens
20 RAC1 5879
Reconstituted Complex Homo sapiens
21 FES 2242
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
22 ACTR1A 10121
Proximity Label-MS Homo sapiens
23 PIK3CG  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
24 BRPF3  
Affinity Capture-MS Homo sapiens
25 YWHAG 7532
Affinity Capture-MS Homo sapiens
26 GAB2 9846
Affinity Capture-Western Homo sapiens
27 MCM6 4175
Affinity Capture-MS Homo sapiens
28 RHOA 387
Reconstituted Complex Homo sapiens
29 TULP3 7289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 YWHAH 7533
Affinity Capture-MS Homo sapiens
31 NAGK 55577
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 CSNK2B 1460
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 HSPD1 3329
Affinity Capture-Western Homo sapiens
34 HSPA8 3312
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
35 YWHAB 7529
Affinity Capture-MS Homo sapiens
36 PFN1 5216
Proximity Label-MS Homo sapiens
37 XPO1 7514
Affinity Capture-MS Homo sapiens
38 USP15 9958
Affinity Capture-MS Homo sapiens
39 KIT 3815
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
40 ARHGEF39 84904
Affinity Capture-MS Homo sapiens
41 HCK 3055
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 CBL 867
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
43 UBASH3B 84959
Affinity Capture-MS Homo sapiens
44 SP110  
Affinity Capture-MS Homo sapiens
45 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
46 BACE2 25825
Affinity Capture-MS Homo sapiens
47 CRKL 1399
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
48 SYNC  
Affinity Capture-MS Homo sapiens
49 Numb  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
50 ARRDC3 57561
Affinity Capture-MS Homo sapiens
51 UNC119 9094
Two-hybrid Homo sapiens
52 PIK3R1 5295
Far Western Homo sapiens
53 NTRK1 4914
Affinity Capture-MS Homo sapiens
54 PXN 5829
Affinity Capture-Western Homo sapiens
55 PTPN6 5777
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
56 JPH4 84502
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 CECR2  
Affinity Capture-MS Homo sapiens
58 SEC13 6396
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 SURF6  
Affinity Capture-MS Homo sapiens
60 YWHAZ 7534
Affinity Capture-MS Homo sapiens
61 HOOK3 84376
Proximity Label-MS Homo sapiens
62 Grasp  
Two-hybrid Rattus norvegicus
63 WEE1 7465
Affinity Capture-MS Homo sapiens
64 PSD4  
Affinity Capture-MS Homo sapiens
65 AP2M1 1173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 MAPRE3  
Proximity Label-MS Homo sapiens
67 AGO4  
Affinity Capture-MS Homo sapiens
68 LRRK1 79705
Affinity Capture-MS Homo sapiens
69 MCM4 4173
Affinity Capture-MS Homo sapiens
70 MYC  
Affinity Capture-MS Homo sapiens
71 RPA3 6119
Proximity Label-MS Homo sapiens
72 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 PTGES3 10728
Affinity Capture-Western Homo sapiens
74 HSPA4 3308
Affinity Capture-Western Homo sapiens
75 RHOB 388
Proximity Label-MS Homo sapiens
76 CTNNA1 1495
Proximity Label-MS Homo sapiens
77 PDZK1 5174
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 INPP5D 3635
Affinity Capture-Western Homo sapiens
79 NAA10 8260
Affinity Capture-MS Homo sapiens
80 COMMD1 150684
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 HIF1A 3091
Affinity Capture-Western Homo sapiens
82 STUB1 10273
Biochemical Activity Homo sapiens
83 GRK5 2869
Affinity Capture-MS Homo sapiens
84 Scai 320271
Affinity Capture-MS Mus musculus
85 SLA2 84174
Affinity Capture-MS Homo sapiens
86 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
87 GRB2 2885
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
88 VPS28 51160
Affinity Capture-Western Homo sapiens
89 TP53 7157
Co-localization Homo sapiens
Two-hybrid Homo sapiens
90 CDC42 998
Reconstituted Complex Homo sapiens
91 USP1 7398
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
92 RSPH9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 EZR 7430
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 SQSTM1 8878
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
95 ABL1 25
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
96 DCTN2 10540
Proximity Label-MS Homo sapiens
97 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
98 DDX58 23586
Affinity Capture-RNA Homo sapiens
99 RB1 5925
Affinity Capture-Western Homo sapiens
100 ERCC3  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Far Western Homo sapiens
Two-hybrid Homo sapiens
101 DOK1 1796
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
102 GABRR1  
Affinity Capture-MS Homo sapiens
103 RAB2A 5862
Proximity Label-MS Homo sapiens
104 DDR1 780
Affinity Capture-MS Homo sapiens
105 CEP135  
Proximity Label-MS Homo sapiens
106 CLTA 1211
Proximity Label-MS Homo sapiens
107 IGSF21  
Two-hybrid Homo sapiens
108 PIK3R2 5296
Affinity Capture-MS Homo sapiens
109 ANK3  
Proximity Label-MS Homo sapiens
110 SMURF2 64750
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
111 LNX1  
Two-hybrid Homo sapiens
View the network image/svg+xml



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