Gene description for CRKL
Gene name v-crk avian sarcoma virus CT10 oncogene homolog-like
Gene symbol CRKL
Other names/aliases -
Species Homo sapiens
 Database cross references - CRKL
ExoCarta ExoCarta_1399
Vesiclepedia VP_1399
Entrez Gene 1399
HGNC 2363
MIM 602007
UniProt P46109  
 CRKL identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
 Gene ontology annotations for CRKL
Molecular Function
    phosphotyrosine residue binding GO:0001784 IPI
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    receptor tyrosine kinase binding GO:0030971 IBA
    signaling adaptor activity GO:0035591 IBA
    identical protein binding GO:0042802 IPI
    cadherin binding GO:0045296 HDA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IDA
Biological Process
    regulation of cell growth GO:0001558 IEA
    blood vessel development GO:0001568 IEA
    urogenital system development GO:0001655 IEA
    neuron migration GO:0001764 IEA
    B cell apoptotic process GO:0001783 IEA
    negative regulation of protein phosphorylation GO:0001933 IMP
    positive regulation of protein phosphorylation GO:0001934 IMP
    outflow tract morphogenesis GO:0003151 IEA
    lipid metabolic process GO:0006629 IEA
    enzyme-linked receptor protein signaling pathway GO:0007167 IBA
    JNK cascade GO:0007254 TAS
    Ras protein signal transduction GO:0007265 TAS
    spermatogenesis GO:0007283 IEA
    single fertilization GO:0007338 IEA
    positive regulation of cell population proliferation GO:0008284 IMP
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    male gonad development GO:0008584 IEA
    anterior/posterior pattern specification GO:0009952 IEA
    negative regulation of gene expression GO:0010629 IMP
    dendrite development GO:0016358 IEA
    cell migration GO:0016477 IBA
    hippocampus development GO:0021766 IEA
    cerebral cortex development GO:0021987 IEA
    establishment of cell polarity GO:0030010 IEA
    regulation of cell adhesion mediated by integrin GO:0033628 IEA
    positive regulation of Rac protein signal transduction GO:0035022 IEA
    intracellular signal transduction GO:0035556 TAS
    helper T cell diapedesis GO:0035685 IEA
    reelin-mediated signaling pathway GO:0038026 IEA
    retinoic acid receptor signaling pathway GO:0048384 IEA
    thymus development GO:0048538 IEA
    regulation of dendrite development GO:0050773 IEA
    T cell receptor signaling pathway GO:0050852 IEA
    parathyroid gland development GO:0060017 IEA
    cell chemotaxis GO:0060326 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IBA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP
    cellular response to xenobiotic stimulus GO:0071466 IEA
    cellular response to transforming growth factor beta stimulus GO:0071560 IMP
    endothelin receptor signaling pathway GO:0086100 IEA
    acetylcholine receptor signaling pathway GO:0095500 IEA
    postsynaptic specialization assembly GO:0098698 IEA
    cerebellar neuron development GO:0098749 IEA
    cellular response to interleukin-7 GO:0098761 IEA
    chordate pharynx development GO:0160093 IEA
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IMP
    positive regulation of glial cell migration GO:1903977 IMP
    positive regulation of skeletal muscle acetylcholine-gated channel clustering GO:1904395 IEA
    cranial skeletal system development GO:1904888 IEA
    regulation of T cell migration GO:2000404 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    neuromuscular junction GO:0031594 IEA
    protein-containing complex GO:0032991 IEA
    extrinsic component of postsynaptic membrane GO:0098890 IEA
 Experiment description of studies that identified CRKL in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
12
Experiment ID 211
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 212
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 275
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
18
Experiment ID 274
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for CRKL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 Pik3r2  
Affinity Capture-MS Mus musculus
3 SGK223  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ETV6  
Affinity Capture-Western Homo sapiens
5 SHC1 6464
Affinity Capture-Western Homo sapiens
6 CD34  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 RIN3  
Affinity Capture-MS Homo sapiens
8 CRK 1398
Negative Genetic Homo sapiens
9 ABL1 25
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
10 EPS15 2060
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 KIF20A 10112
Affinity Capture-MS Homo sapiens
12 IMPACT 55364
Affinity Capture-MS Homo sapiens
13 GDPGP1  
Affinity Capture-MS Homo sapiens
14 PTPN11 5781
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
15 CAPZB 832
Affinity Capture-MS Homo sapiens
16 WAS 7454
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
17 GPATCH4 54865
Affinity Capture-MS Homo sapiens
18 KIF23 9493
Affinity Capture-MS Homo sapiens
19 MCM2 4171
Affinity Capture-MS Homo sapiens
20 RAF1 5894
Co-localization Homo sapiens
21 PNRC1 10957
Affinity Capture-MS Homo sapiens
22 TELO2 9894
Affinity Capture-MS Homo sapiens
23 PTPN4  
Affinity Capture-MS Homo sapiens
24 MAP4K5 11183
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
25 KHDRBS1 10657
Two-hybrid Homo sapiens
26 SYK 6850
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
27 PEAK1 79834
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 EPOR  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
29 SLX4  
Affinity Capture-MS Homo sapiens
30 ELMO2 63916
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 DDX6 1656
Affinity Capture-MS Homo sapiens
32 DOCK1 1793
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 FCGR1A  
Affinity Capture-Western Homo sapiens
34 CBLB 868
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 USP7 7874
Affinity Capture-MS Homo sapiens
36 ERBB2 2064
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
37 FGFR1 2260
Affinity Capture-Western Homo sapiens
38 ARHGAP9 64333
Affinity Capture-MS Homo sapiens
39 KIF14 9928
Affinity Capture-MS Homo sapiens
40 PRNP 5621
Affinity Capture-MS Homo sapiens
41 PLEKHA1 59338
Two-hybrid Homo sapiens
42 MAPK1 5594
Co-localization Homo sapiens
43 EDC4 23644
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 NEDD9 4739
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
45 BCAR1 9564
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
46 STAT5A 6776
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
47 KIT 3815
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
48 PLSCR1 5359
Two-hybrid Homo sapiens
49 IFIT5 24138
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 HCK 3055
Co-localization Homo sapiens
51 IGF1R 3480
Co-localization Homo sapiens
52 ERBB3 2065
Protein-peptide Homo sapiens
53 CBL 867
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
54 GORAB 92344
Affinity Capture-MS Homo sapiens
55 CDH1 999
Proximity Label-MS Homo sapiens
56 CHMP4B 128866
Affinity Capture-MS Homo sapiens
57 TYK2 7297
Affinity Capture-Western Homo sapiens
58 NTRK1 4914
Affinity Capture-MS Homo sapiens
59 RPL31 6160
Two-hybrid Homo sapiens
60 MEGF6  
Two-hybrid Homo sapiens
61 DCP1A 55802
Affinity Capture-MS Homo sapiens
62 RPA4  
Proximity Label-MS Homo sapiens
63 CRY2  
Affinity Capture-MS Homo sapiens
64 FLT1 2321
Co-localization Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
65 PIK3R1 5295
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
66 KIAA0430  
Affinity Capture-MS Homo sapiens
67 C19orf35  
Affinity Capture-MS Homo sapiens
68 GAREM  
Two-hybrid Homo sapiens
69 CLIC4 25932
Co-fractionation Homo sapiens
70 SP100 6672
Affinity Capture-MS Homo sapiens
71 PIK3CB 5291
Affinity Capture-MS Homo sapiens
72 BAG3 9531
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
73 OGT 8473
Co-fractionation Homo sapiens
74 ARHGAP32  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
75 ELMO1 9844
Affinity Capture-MS Homo sapiens
76 PTEN 5728
Affinity Capture-MS Homo sapiens
77 EGLN3  
Affinity Capture-MS Homo sapiens
78 AOX1 316
Two-hybrid Homo sapiens
79 APOB 338
Affinity Capture-MS Homo sapiens
80 PDGFRA 5156
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
81 ARHGAP42  
Affinity Capture-MS Homo sapiens
82 ASAP3 55616
Affinity Capture-MS Homo sapiens
83 LTBP4 8425
Two-hybrid Homo sapiens
84 EGFR 1956
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Co-localization Homo sapiens
85 YY1 7528
Two-hybrid Homo sapiens
86 C15orf54  
Affinity Capture-MS Homo sapiens
87 PTK2 5747
Co-localization Homo sapiens
88 PDGFRB 5159
Co-localization Homo sapiens
89 HIP1R 9026
Co-fractionation Homo sapiens
90 UBL5 59286
Affinity Capture-MS Homo sapiens
91 ABL2  
Affinity Capture-MS Homo sapiens
92 GAB1  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
93 NXF1 10482
Affinity Capture-RNA Homo sapiens
94 PRR3  
Affinity Capture-MS Homo sapiens
95 MYC  
Affinity Capture-MS Homo sapiens
96 RPA3 6119
Proximity Label-MS Homo sapiens
97 ARHGEF5  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
98 MSL1 339287
Two-hybrid Homo sapiens
99 MPZL1 9019
Affinity Capture-MS Homo sapiens
100 TNS2 23371
Two-hybrid Homo sapiens
101 BICD1 636
Proximity Label-MS Homo sapiens
102 INPP5D 3635
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
103 ASAP1 50807
Affinity Capture-MS Homo sapiens
104 WAC  
Two-hybrid Homo sapiens
105 HUWE1 10075
Affinity Capture-MS Homo sapiens
106 CD99L2 83692
Cross-Linking-MS (XL-MS) Homo sapiens
107 PHC2  
Two-hybrid Homo sapiens
108 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
109 GRN 2896
Two-hybrid Homo sapiens
110 HNRNPH2 3188
Co-fractionation Homo sapiens
111 DOCK2 1794
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
112 SHANK3 85358
Two-hybrid Homo sapiens
113 GRB2 2885
Affinity Capture-Western Homo sapiens
114 DOCK5 80005
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 NOTCH2 4853
Two-hybrid Homo sapiens
116 RAPGEF1 2889
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
117 EPHA4 2043
Cross-Linking-MS (XL-MS) Homo sapiens
118 PDCD6 10016
Co-fractionation Homo sapiens
119 MAGEL2  
Proximity Label-MS Homo sapiens
120 SOS1 6654
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
121 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
122 OTUB1 55611
Affinity Capture-MS Homo sapiens
123 GAB2 9846
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
124 PPFIBP2 8495
Two-hybrid Homo sapiens
125 TRAP1 10131
Affinity Capture-MS Homo sapiens
126 BIK  
Two-hybrid Homo sapiens
127 DOK1 1796
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
128 MOV10 4343
Affinity Capture-RNA Homo sapiens
129 PXN 5829
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
130 LAMA5 3911
Two-hybrid Homo sapiens
131 EDC3 80153
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 SOS2 6655
Affinity Capture-MS Homo sapiens
133 PIK3R2 5296
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
134 CUL7 9820
Affinity Capture-MS Homo sapiens
135 POLR1D 51082
Two-hybrid Homo sapiens
136 BLNK  
Affinity Capture-Western Homo sapiens
137 IRS4 8471
Reconstituted Complex Homo sapiens
138 DCP2  
Affinity Capture-MS Homo sapiens
139 SEPHS1 22929
Co-fractionation Homo sapiens
140 MAP4K1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
141 BCR 613
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here