Gene description for NOTCH2
Gene name notch 2
Gene symbol NOTCH2
Other names/aliases AGS2
HJCYS
hN2
Species Homo sapiens
 Database cross references - NOTCH2
ExoCarta ExoCarta_4853
Vesiclepedia VP_4853
Entrez Gene 4853
HGNC 7882
MIM 600275
UniProt Q04721  
 NOTCH2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Endothelial cells 26027894    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocytes 26054723    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for NOTCH2
Molecular Function
    cis-regulatory region sequence-specific DNA binding GO:0000987 IDA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IEA
    signaling receptor activity GO:0038023 NAS
    NF-kappaB binding GO:0051059 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    in utero embryonic development GO:0001701 IEA
    cell fate determination GO:0001709 TAS
    heart looping GO:0001947 IEA
    morphogenesis of an epithelial sheet GO:0002011 IEA
    marginal zone B cell differentiation GO:0002315 ISS
    inflammatory response to antigenic stimulus GO:0002437 IEA
    atrioventricular node development GO:0003162 NAS
    pulmonary valve morphogenesis GO:0003184 IMP
    apoptotic process GO:0006915 TAS
    humoral immune response GO:0006959 IEA
    Notch signaling pathway GO:0007219 IBA
    Notch signaling pathway GO:0007219 IDA
    Notch signaling pathway GO:0007219 IMP
    nervous system development GO:0007399 NAS
    axon guidance GO:0007411 IBA
    animal organ morphogenesis GO:0009887 IEP
    negative regulation of gene expression GO:0010629 IDA
    positive regulation of keratinocyte proliferation GO:0010838 IDA
    hemopoiesis GO:0030097 TAS
    embryonic limb morphogenesis GO:0030326 IEA
    BMP signaling pathway GO:0030509 IEA
    positive regulation of BMP signaling pathway GO:0030513 IEA
    multicellular organism growth GO:0035264 IEA
    intracellular signal transduction GO:0035556 IDA
    intrahepatic bile duct development GO:0035622 IEA
    wound healing GO:0042060 IEA
    defense response to bacterium GO:0042742 IEA
    myeloid dendritic cell differentiation GO:0043011 IEA
    positive regulation of apoptotic process GO:0043065 IEA
    negative regulation of apoptotic process GO:0043066 TAS
    positive regulation of osteoclast differentiation GO:0045672 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of Ras protein signal transduction GO:0046579 IDA
    bone remodeling GO:0046849 IMP
    positive regulation of smooth muscle cell differentiation GO:0051152 IDA
    atrial septum morphogenesis GO:0060413 IMP
    placenta blood vessel development GO:0060674 IEA
    ciliary body morphogenesis GO:0061073 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    left/right axis specification GO:0070986 IEA
    cellular response to tumor cell GO:0071228 IDA
    proximal tubule development GO:0072014 IEA
    podocyte development GO:0072015 IEA
    glomerular capillary formation GO:0072104 IEA
    hepatocyte proliferation GO:0072574 IEA
    positive regulation of miRNA transcription GO:1902895 IMP
    cholangiocyte proliferation GO:1990705 IEA
    regulation of osteoclast development GO:2001204 IMP
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    extracellular region GO:0005576 TAS
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    endoplasmic reticulum membrane GO:0005789 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    cilium GO:0005929 IEA
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    membrane GO:0016020 HDA
    receptor complex GO:0043235 IBA
    receptor complex GO:0043235 IDA
 Experiment description of studies that identified NOTCH2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
11
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
12
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
16
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
17
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NOTCH2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 ZNF407  
Affinity Capture-MS Homo sapiens
3 ZNF282  
Affinity Capture-MS Homo sapiens
4 ZKSCAN1  
Affinity Capture-MS Homo sapiens
5 ZNF668  
Affinity Capture-MS Homo sapiens
6 LRRIQ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 GJD3  
Proximity Label-MS Homo sapiens
8 SLIT2 9353
Affinity Capture-MS Homo sapiens
9 NOTCH3 4854
Affinity Capture-MS Homo sapiens
10 NPNT 255743
Affinity Capture-MS Homo sapiens
11 PATZ1  
Affinity Capture-MS Homo sapiens
12 INHBE 83729
Affinity Capture-MS Homo sapiens
13 ZNF761  
Affinity Capture-MS Homo sapiens
14 OCLN 100506658
Proximity Label-MS Homo sapiens
15 FBN2 2201
Affinity Capture-MS Homo sapiens
16 ZNF649  
Affinity Capture-MS Homo sapiens
17 METTL7A 25840
Proximity Label-MS Homo sapiens
18 LAMP3  
Proximity Label-MS Homo sapiens
19 ATG9A 79065
Proximity Label-MS Homo sapiens
20 ZXDC  
Affinity Capture-MS Homo sapiens
21 GJA1 2697
Proximity Label-MS Homo sapiens
22 ZNF324B  
Affinity Capture-MS Homo sapiens
23 ZNF107  
Affinity Capture-MS Homo sapiens
24 ZNF253  
Affinity Capture-MS Homo sapiens
25 ASPH 444
Affinity Capture-MS Homo sapiens
26 PARD3 56288
Proximity Label-MS Homo sapiens
27 TRIM66  
Affinity Capture-MS Homo sapiens
28 MARCH2  
Affinity Capture-MS Homo sapiens
29 CFC1  
Affinity Capture-MS Homo sapiens
30 MYOC 4653
Two-hybrid Homo sapiens
31 ZNF32  
Affinity Capture-MS Homo sapiens
32 RPL10 6134
Affinity Capture-MS Homo sapiens
33 LGALS1 3956
Affinity Capture-MS Homo sapiens
34 HSD17B11 51170
Proximity Label-MS Homo sapiens
35 LAMP2 3920
Proximity Label-MS Homo sapiens
36 DNAJC25 548645
Proximity Label-MS Homo sapiens
37 ZNF888  
Affinity Capture-MS Homo sapiens
38 IGFBP4 3487
Affinity Capture-MS Homo sapiens
39 SLURP1  
Affinity Capture-MS Homo sapiens
40 RABGGTB 5876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 ANKRD28 23243
Proximity Label-MS Homo sapiens
42 ZNF358 140467
Affinity Capture-MS Homo sapiens
43 SCARF2 91179
Affinity Capture-MS Homo sapiens
44 ZNF687  
Affinity Capture-MS Homo sapiens
45 ZBTB17  
Affinity Capture-MS Homo sapiens
46 ZNF397  
Affinity Capture-MS Homo sapiens
47 B3GAT1  
Proximity Label-MS Homo sapiens
48 RDX 5962
Co-fractionation Homo sapiens
49 SULF2 55959
Affinity Capture-MS Homo sapiens
50 MLLT4 4301
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
51 JAG1 182
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
52 ZFP64  
Affinity Capture-MS Homo sapiens
53 DYRK1A 1859
Affinity Capture-MS Homo sapiens
54 ZBTB21  
Affinity Capture-MS Homo sapiens
55 ZNF623  
Affinity Capture-MS Homo sapiens
56 CCR2  
Two-hybrid Homo sapiens
57 RNASE4 6038
Affinity Capture-MS Homo sapiens
58 DUSP11  
Affinity Capture-MS Homo sapiens
59 SEC24C 9632
Co-fractionation Homo sapiens
60 RAB3B 5865
Proximity Label-MS Homo sapiens
61 PRC1 9055
Affinity Capture-MS Homo sapiens
62 ZNF518A 9849
Affinity Capture-MS Homo sapiens
63 CLEC2B  
Affinity Capture-MS Homo sapiens
64 MAZ 4150
Affinity Capture-MS Homo sapiens
65 MARCH1  
Affinity Capture-MS Homo sapiens
66 ZNF320  
Affinity Capture-MS Homo sapiens
67 ZNF460  
Affinity Capture-MS Homo sapiens
68 ST14 6768
Affinity Capture-MS Homo sapiens
69 OBSL1 23363
Affinity Capture-MS Homo sapiens
70 C11orf52 91894
Proximity Label-MS Homo sapiens
71 PIGH  
Affinity Capture-MS Homo sapiens
72 ZNF408  
Affinity Capture-MS Homo sapiens
73 POLRMT 5442
Affinity Capture-MS Homo sapiens
74 ADAMTS1 9510
Affinity Capture-MS Homo sapiens
75 FOXD4L6  
Affinity Capture-MS Homo sapiens
76 ZBTB39  
Affinity Capture-MS Homo sapiens
77 ZNF431  
Affinity Capture-MS Homo sapiens
78 STX6 10228
Proximity Label-MS Homo sapiens
79 IGFL3  
Affinity Capture-MS Homo sapiens
80 NDUFV1 4723
Co-fractionation Homo sapiens
81 ZNF526  
Affinity Capture-MS Homo sapiens
82 SENP5  
Affinity Capture-MS Homo sapiens
83 ZNF446  
Affinity Capture-MS Homo sapiens
84 ZKSCAN2  
Affinity Capture-MS Homo sapiens
85 BMPER 168667
Affinity Capture-MS Homo sapiens
86 RAB35 11021
Proximity Label-MS Homo sapiens
87 ELSPBP1  
Affinity Capture-MS Homo sapiens
88 ZNF780A  
Affinity Capture-MS Homo sapiens
89 CYR61 3491
Affinity Capture-MS Homo sapiens
90 EBAG9 9166
Proximity Label-MS Homo sapiens
91 ZNF341  
Affinity Capture-MS Homo sapiens
92 MARCKS 4082
Proximity Label-MS Homo sapiens
93 ADAMTS15 170689
Affinity Capture-MS Homo sapiens
94 GSK3B 2932
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
95 LAMTOR1 55004
Proximity Label-MS Homo sapiens
96 RPS26 6231
Affinity Capture-MS Homo sapiens
97 TAF5L  
Affinity Capture-MS Homo sapiens
98 CBX6  
Affinity Capture-MS Homo sapiens
99 LMAN1 3998
Proximity Label-MS Homo sapiens
100 ZNF579  
Affinity Capture-MS Homo sapiens
101 CRISPLD1 83690
Affinity Capture-MS Homo sapiens
102 RAB5A 5868
Proximity Label-MS Homo sapiens
103 BRICD5  
Affinity Capture-MS Homo sapiens
104 RPL17 6139
Affinity Capture-MS Homo sapiens
105 ZNF696  
Affinity Capture-MS Homo sapiens
106 PLAUR 5329
Co-fractionation Homo sapiens
107 VEZF1  
Affinity Capture-MS Homo sapiens
108 ZNF555  
Affinity Capture-MS Homo sapiens
109 ZBTB48  
Affinity Capture-MS Homo sapiens
110 ZNF189  
Affinity Capture-MS Homo sapiens
111 ZNF777  
Affinity Capture-MS Homo sapiens
112 ZNF444  
Affinity Capture-MS Homo sapiens
113 ZBTB9  
Affinity Capture-MS Homo sapiens
114 EMD 2010
Proximity Label-MS Homo sapiens
115 FBLN1 2192
Affinity Capture-MS Homo sapiens
116 NTN1 9423
Affinity Capture-MS Homo sapiens
117 ZNF430  
Affinity Capture-MS Homo sapiens
118 ZC3H3  
Affinity Capture-MS Homo sapiens
119 CXADR 1525
Proximity Label-MS Homo sapiens
120 IGSF5  
Affinity Capture-MS Homo sapiens
121 ADAMTS9  
Affinity Capture-MS Homo sapiens
122 PRSS12 8492
Affinity Capture-MS Homo sapiens
123 ZNF324  
Affinity Capture-MS Homo sapiens
124 LYN 4067
Proximity Label-MS Homo sapiens
125 ZNF480 147657
Affinity Capture-MS Homo sapiens
126 MCAM 4162
Proximity Label-MS Homo sapiens
127 MYNN 55892
Affinity Capture-MS Homo sapiens
128 RAB4A 5867
Proximity Label-MS Homo sapiens
129 WISP3  
Affinity Capture-MS Homo sapiens
130 ZKSCAN8  
Affinity Capture-MS Homo sapiens
131 DNAJC5 80331
Proximity Label-MS Homo sapiens
132 ZBTB33  
Affinity Capture-MS Homo sapiens
133 EMILIN2 84034
Affinity Capture-MS Homo sapiens
134 MKRN2 23609
Affinity Capture-RNA Homo sapiens
135 ZFP41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 SP1  
Affinity Capture-MS Homo sapiens
137 DIRAS3  
Proximity Label-MS Homo sapiens
138 CRKL 1399
Two-hybrid Homo sapiens
139 ZNF512  
Affinity Capture-MS Homo sapiens
140 CNTN1 1272
Affinity Capture-Western Homo sapiens
141 DTX2 113878
Proximity Label-MS Homo sapiens
142 EEF2 1938
Co-fractionation Homo sapiens
143 ZSCAN26  
Affinity Capture-MS Homo sapiens
144 CDH1 999
Proximity Label-MS Homo sapiens
145 JAG2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
146 NDNF  
Affinity Capture-MS Homo sapiens
147 LYPD1  
Affinity Capture-MS Homo sapiens
148 ZFP91 80829
Affinity Capture-MS Homo sapiens
149 RPN1 6184
Proximity Label-MS Homo sapiens
150 WNT10A  
Affinity Capture-MS Homo sapiens
151 Bmpr1a  
Affinity Capture-MS Mus musculus
152 ZNF483  
Affinity Capture-MS Homo sapiens
153 ZNF813  
Affinity Capture-MS Homo sapiens
154 PDIA6 10130
Co-fractionation Homo sapiens
155 ZNF708  
Affinity Capture-MS Homo sapiens
156 LATS2 26524
Proximity Label-MS Homo sapiens
157 RPS26P11  
Affinity Capture-MS Homo sapiens
158 ELOVL5 60481
Proximity Label-MS Homo sapiens
159 ADAMTS17  
Affinity Capture-MS Homo sapiens
160 SEC61B 10952
Proximity Label-MS Homo sapiens
161 SP2  
Affinity Capture-MS Homo sapiens
162 ZBTB44  
Affinity Capture-MS Homo sapiens
163 ZNF574  
Affinity Capture-MS Homo sapiens
164 PPP1R12B 4660
Affinity Capture-MS Homo sapiens
165 ZNF747  
Affinity Capture-MS Homo sapiens
166 ZNF398  
Affinity Capture-MS Homo sapiens
167 TJP1 7082
Co-fractionation Homo sapiens
168 MARCH3 115123
Affinity Capture-MS Homo sapiens
169 HSPA5 3309
Affinity Capture-MS Homo sapiens
170 ZNF316  
Affinity Capture-MS Homo sapiens
171 E4F1  
Affinity Capture-MS Homo sapiens
172 PLAT 5327
Affinity Capture-MS Homo sapiens
173 ZNF664  
Affinity Capture-MS Homo sapiens
174 PRG3  
Affinity Capture-MS Homo sapiens
175 MRPS12  
Affinity Capture-MS Homo sapiens
176 ZNF768 79724
Affinity Capture-MS Homo sapiens
177 RPS2 6187
Affinity Capture-MS Homo sapiens
178 ZNF611  
Affinity Capture-MS Homo sapiens
179 LRRC59 55379
Proximity Label-MS Homo sapiens
180 PANX1 24145
Proximity Label-MS Homo sapiens
181 ZBTB24  
Affinity Capture-MS Homo sapiens
182 WNT5A 7474
Affinity Capture-MS Homo sapiens
183 LAMB2 3913
Affinity Capture-MS Homo sapiens
184 EPB41L4A 64097
Proximity Label-MS Homo sapiens
185 LAMP1 3916
Proximity Label-MS Homo sapiens
186 MARCH8  
Affinity Capture-MS Homo sapiens
187 MAML1  
Reconstituted Complex Homo sapiens
188 PRG2  
Affinity Capture-MS Homo sapiens
189 HSD3B7 80270
Proximity Label-MS Homo sapiens
190 CUL3 8452
Affinity Capture-MS Homo sapiens
191 CACNG3  
Affinity Capture-MS Homo sapiens
192 LTBP4 8425
Affinity Capture-MS Homo sapiens
193 TMEM9B 56674
Affinity Capture-MS Homo sapiens
194 EGFL7 51162
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
195 ARF6 382
Proximity Label-MS Homo sapiens
196 ZNF771  
Affinity Capture-MS Homo sapiens
197 SMOC1 64093
Affinity Capture-MS Homo sapiens
198 ZNF275  
Affinity Capture-MS Homo sapiens
199 CDC42 998
Co-fractionation Homo sapiens
200 SMAD1 4086
Two-hybrid Homo sapiens
201 ZNF672 79894
Affinity Capture-MS Homo sapiens
202 SUPT3H  
Affinity Capture-MS Homo sapiens
203 GRN 2896
Affinity Capture-MS Homo sapiens
204 ZNF594  
Affinity Capture-MS Homo sapiens
205 ZNF92  
Affinity Capture-MS Homo sapiens
206 SPEN 23013
Co-fractionation Homo sapiens
207 ZNF628  
Affinity Capture-MS Homo sapiens
208 ATP2A1 487
Proximity Label-MS Homo sapiens
209 FBXO2 26232
Affinity Capture-MS Homo sapiens
210 ZMYND8 23613
Affinity Capture-MS Homo sapiens
211 RAB9A 9367
Proximity Label-MS Homo sapiens
212 ZNF587B  
Affinity Capture-MS Homo sapiens
213 TIMP3 7078
Affinity Capture-MS Homo sapiens
214 ZSCAN2  
Affinity Capture-MS Homo sapiens
215 DLL1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
216 ZNF121  
Affinity Capture-MS Homo sapiens
217 ZNF724P  
Affinity Capture-MS Homo sapiens
218 LTBP1 4052
Affinity Capture-MS Homo sapiens
219 RPL24 6152
Affinity Capture-MS Homo sapiens
220 PXDN 7837
Affinity Capture-MS Homo sapiens
221 RHOB 388
Proximity Label-MS Homo sapiens
222 RPUSD4 84881
Affinity Capture-MS Homo sapiens
223 EDN3  
Affinity Capture-MS Homo sapiens
224 ZNF136  
Affinity Capture-MS Homo sapiens
225 MSN 4478
Co-fractionation Homo sapiens
226 NDUFV2 4729
Co-fractionation Homo sapiens
227 C9orf163  
Affinity Capture-MS Homo sapiens
228 WNT2  
Affinity Capture-MS Homo sapiens
229 RPS23 6228
Affinity Capture-MS Homo sapiens
230 PSMB1 5689
Co-fractionation Homo sapiens
231 ZNF787  
Affinity Capture-MS Homo sapiens
232 FLOT1 10211
Proximity Label-MS Homo sapiens
233 ZNF263  
Affinity Capture-MS Homo sapiens
234 PIGR 5284
Affinity Capture-MS Homo sapiens
235 ZNF276 92822
Affinity Capture-MS Homo sapiens
236 XXYLT1 152002
Affinity Capture-MS Homo sapiens
237 ZNF765  
Affinity Capture-MS Homo sapiens
238 ZNF219  
Affinity Capture-MS Homo sapiens
239 ZNF417  
Affinity Capture-MS Homo sapiens
240 ZNF624 57547
Affinity Capture-MS Homo sapiens
241 ZNF707  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
242 RBPJ 3516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
243 PRKCSH 5589
Cross-Linking-MS (XL-MS) Homo sapiens
244 FIZ1  
Affinity Capture-MS Homo sapiens
245 ZNF689  
Affinity Capture-MS Homo sapiens
246 ZNF592 9640
Affinity Capture-MS Homo sapiens
247 CKAP4 10970
Proximity Label-MS Homo sapiens
248 SIN3A  
Co-fractionation Homo sapiens
249 ZNF235  
Affinity Capture-MS Homo sapiens
250 ZNF783  
Affinity Capture-MS Homo sapiens
251 MDK 4192
Affinity Capture-MS Homo sapiens
252 PCMT1 5110
Co-fractionation Homo sapiens
253 DNAJA2 10294
Proximity Label-MS Homo sapiens
254 ZNF746  
Affinity Capture-MS Homo sapiens
255 EZR 7430
Proximity Label-MS Homo sapiens
256 CD55 1604
Affinity Capture-MS Homo sapiens
257 UBA52 7311
Affinity Capture-MS Homo sapiens
258 ZNF823  
Affinity Capture-MS Homo sapiens
259 LCK 3932
Proximity Label-MS Homo sapiens
260 ZSCAN21  
Affinity Capture-MS Homo sapiens
261 RPS4X 6191
Affinity Capture-MS Homo sapiens
262 ZNF48  
Affinity Capture-MS Homo sapiens
263 RPL23 9349
Affinity Capture-MS Homo sapiens
264 ANKRD44 91526
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
265 RBAK  
Affinity Capture-MS Homo sapiens
266 DLK1  
Affinity Capture-MS Homo sapiens
267 FBXL17  
Affinity Capture-MS Homo sapiens
268 ZNF490  
Affinity Capture-MS Homo sapiens
269 WNT10B 7480
Affinity Capture-MS Homo sapiens
270 ERGIC1 57222
Proximity Label-MS Homo sapiens
271 ATP2A2 488
Co-fractionation Homo sapiens
272 ZNF7  
Affinity Capture-MS Homo sapiens
273 ZNF419  
Affinity Capture-MS Homo sapiens
274 RAB11FIP1 80223
Affinity Capture-Western Homo sapiens
275 LATS1  
Proximity Label-MS Homo sapiens
276 ZNF627  
Affinity Capture-MS Homo sapiens
277 ZNF317 57693
Affinity Capture-MS Homo sapiens
278 ZNF497  
Affinity Capture-MS Homo sapiens
279 SULF1 23213
Affinity Capture-MS Homo sapiens
280 ZNF646  
Affinity Capture-MS Homo sapiens
281 TRIM37  
Proximity Label-MS Homo sapiens
282 ZNF335 63925
Affinity Capture-MS Homo sapiens
283 ZNF260  
Affinity Capture-MS Homo sapiens
284 RAB2A 5862
Proximity Label-MS Homo sapiens
285 ASB14  
Affinity Capture-MS Homo sapiens
286 ZNF766  
Affinity Capture-MS Homo sapiens
287 SEC62 7095
Proximity Label-MS Homo sapiens
288 NTN5  
Affinity Capture-MS Homo sapiens
289 ZNF775  
Affinity Capture-MS Homo sapiens
290 ZSCAN25  
Affinity Capture-MS Homo sapiens
291 WNT3A 89780
Affinity Capture-MS Homo sapiens
292 RAB7A 7879
Proximity Label-MS Homo sapiens
293 RAB11A 8766
Proximity Label-MS Homo sapiens
294 ZNF791  
Affinity Capture-MS Homo sapiens
295 RPS27A 6233
Affinity Capture-MS Homo sapiens
296 EPHA2 1969
Proximity Label-MS Homo sapiens
297 ZNF629 23361
Affinity Capture-MS Homo sapiens
298 GLI4  
Affinity Capture-MS Homo sapiens
299 ZNF445  
Affinity Capture-MS Homo sapiens
300 DNAJC1 64215
Proximity Label-MS Homo sapiens
301 KRAS 3845
Proximity Label-MS Homo sapiens
302 RAB5C 5878
Proximity Label-MS Homo sapiens
303 RPL36AL 6166
Affinity Capture-MS Homo sapiens
304 ZNF709  
Affinity Capture-MS Homo sapiens
305 VASN 114990
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
306 STX4 6810
Proximity Label-MS Homo sapiens
307 ZNF362  
Affinity Capture-MS Homo sapiens
308 CILP2  
Affinity Capture-MS Homo sapiens
309 ZNF142  
Affinity Capture-MS Homo sapiens
310 CAV1 857
Proximity Label-MS Homo sapiens
311 REPIN1  
Affinity Capture-MS Homo sapiens
312 NOTCH1 4851
Affinity Capture-MS Homo sapiens
313 AGRP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
314 PRKRIR  
Affinity Capture-MS Homo sapiens
315 ZNF865  
Affinity Capture-MS Homo sapiens
316 ZNF146  
Affinity Capture-MS Homo sapiens
317 GREM2 64388
Affinity Capture-MS Homo sapiens
318 DERL1 79139
Proximity Label-MS Homo sapiens
319 ZBTB45  
Affinity Capture-MS Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here