Gene description for PLCG1
Gene name phospholipase C, gamma 1
Gene symbol PLCG1
Other names/aliases NCKAP3
PLC-II
PLC1
PLC148
PLCgamma1
Species Homo sapiens
 Database cross references - PLCG1
ExoCarta ExoCarta_5335
Vesiclepedia VP_5335
Entrez Gene 5335
HGNC 9065
MIM 172420
UniProt P19174  
 PLCG1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 34887515    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for PLCG1
Molecular Function
    phosphatidylinositol phospholipase C activity GO:0004435 IBA
    phosphatidylinositol phospholipase C activity GO:0004435 IDA
    phosphatidylinositol phospholipase C activity GO:0004435 TAS
    phospholipase C activity GO:0004629 IDA
    phospholipase C activity GO:0004629 IMP
    phospholipase C activity GO:0004629 TAS
    guanyl-nucleotide exchange factor activity GO:0005085 ISS
    neurotrophin TRKA receptor binding GO:0005168 IPI
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IPI
    receptor tyrosine kinase binding GO:0030971 IEA
    glutamate receptor binding GO:0035254 IEA
    calcium-dependent phospholipase C activity GO:0050429 ISS
Biological Process
    in utero embryonic development GO:0001701 IEA
    negative regulation of inflammatory response to antigenic stimulus GO:0002862 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 IMP
    epidermal growth factor receptor signaling pathway GO:0007173 ISS
    phospholipid catabolic process GO:0009395 IEA
    positive regulation of epithelial cell migration GO:0010634 IBA
    positive regulation of epithelial cell migration GO:0010634 IMP
    cell migration GO:0016477 IMP
    calcium-mediated signaling GO:0019722 IMP
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    positive regulation of blood vessel endothelial cell migration GO:0043536 IDA
    positive regulation of angiogenesis GO:0045766 IDA
    phosphatidylinositol metabolic process GO:0046488 IBA
    phosphatidylinositol metabolic process GO:0046488 ISS
    phosphatidylinositol-mediated signaling GO:0048015 IBA
    modulation of chemical synaptic transmission GO:0050804 IEA
    T cell receptor signaling pathway GO:0050852 TAS
    release of sequestered calcium ion into cytosol GO:0051209 IBA
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IMP
    cellular response to epidermal growth factor stimulus GO:0071364 IDA
    cellular response to epidermal growth factor stimulus GO:0071364 IMP
    positive regulation of vascular endothelial cell proliferation GO:1905564 IMP
    positive regulation of endothelial cell apoptotic process GO:2000353 IMP
Subcellular Localization
    ruffle GO:0001726 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 IEA
    COP9 signalosome GO:0008180 IDA
    lamellipodium GO:0030027 IDA
    ruffle membrane GO:0032587 IBA
    ruffle membrane GO:0032587 IDA
    cell projection GO:0042995 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified PLCG1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
6
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PLCG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 WDR6 11180
Co-fractionation Homo sapiens
3 ARHGEF2 9181
Affinity Capture-Western Homo sapiens
4 SHC1 6464
Affinity Capture-Western Homo sapiens
5 HSPA6 3310
Co-fractionation Homo sapiens
6 SKIV2L 6499
Co-fractionation Homo sapiens
7 DLGAP2  
Affinity Capture-MS Homo sapiens
8 RIN3  
Affinity Capture-MS Homo sapiens
9 COPS5 10987
Co-fractionation Homo sapiens
10 PFKP 5214
Co-fractionation Homo sapiens
11 VPRBP 9730
Co-fractionation Homo sapiens
12 PTPN11 5781
Co-fractionation Homo sapiens
13 SOS1 6654
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
14 TLN1 7094
Co-fractionation Homo sapiens
15 EFTUD1 79631
Co-fractionation Homo sapiens
16 SHB 6461
Affinity Capture-Western Homo sapiens
17 HSP90AB1 3326
Co-fractionation Homo sapiens
18 ROCK2 9475
Co-fractionation Homo sapiens
19 RIC8A 60626
Co-fractionation Homo sapiens
20 COPS4 51138
Co-fractionation Homo sapiens
21 RET 5979
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
22 SRSF2 6427
Affinity Capture-MS Homo sapiens
23 HSPA5 3309
Co-fractionation Homo sapiens
24 SELE  
Affinity Capture-Western Homo sapiens
25 ATXN7L1 222255
Affinity Capture-MS Homo sapiens
26 PLCG2 5336
Co-localization Homo sapiens
27 COPS6 10980
Co-fractionation Homo sapiens
28 ZAP70 7535
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
29 SPANXN4  
Affinity Capture-MS Homo sapiens
30 GAB2 9846
Reconstituted Complex Homo sapiens
31 NPM1 4869
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
32 MST1R 4486
Affinity Capture-Western Homo sapiens
33 SRC 6714
Affinity Capture-Western Homo sapiens
34 KDR  
Reconstituted Complex Homo sapiens
35 RHOA 387
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
36 TEKT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PLD2 5338
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
38 DYNLL1 8655
Co-fractionation Homo sapiens
39 ALK 238
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
40 EPOR  
PCA Homo sapiens
41 UCHL5 51377
Co-fractionation Homo sapiens
42 AASDHPPT 60496
Co-fractionation Homo sapiens
43 SYK 6850
Affinity Capture-Western Homo sapiens
44 TTC9B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 KHDRBS1 10657
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
46 LDLRAD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CTPS1 1503
Co-fractionation Homo sapiens
48 PKN2 5586
Reconstituted Complex Homo sapiens
49 GPS1 2873
Co-fractionation Homo sapiens
50 PLCB3 5331
Co-fractionation Homo sapiens
51 ERBB2 2064
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
52 FGFR1 2260
Two-hybrid Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
53 EEF1A1 1915
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
54 NTMT1 28989
Co-fractionation Homo sapiens
55 MVB12B 89853
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 CACNB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 UNC45A 55898
Co-fractionation Homo sapiens
58 ATXN10 25814
Co-fractionation Homo sapiens
59 CAMK2A 815
Affinity Capture-Western Homo sapiens
60 NSUN2 54888
Co-fractionation Homo sapiens
61 KIT 3815
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
62 NCAM1 4684
Reconstituted Complex Homo sapiens
63 VAV1 7409
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
64 DPYSL4 10570
Affinity Capture-MS Homo sapiens
65 NCKIPSD 51517
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
66 PLXNB1 5364
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
67 PARK2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
68 HCK 3055
Co-localization Homo sapiens
69 PDGFRB 5159
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Co-localization Homo sapiens
70 ERBB3 2065
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
71 CBL 867
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
72 WDR61 80349
Co-fractionation Homo sapiens
73 MAPT  
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Co-fractionation Homo sapiens
Protein-peptide Homo sapiens
74 NTRK3 4916
Reconstituted Complex Homo sapiens
75 GIT1 28964
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
76 SH3BP2  
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
77 MYH9 4627
Co-fractionation Homo sapiens
78 CYS1 192668
Affinity Capture-MS Homo sapiens
79 NTRK1 4914
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
80 SNX11 29916
Affinity Capture-MS Homo sapiens
81 TRPM7 54822
Reconstituted Complex Homo sapiens
82 SYNCRIP 10492
Reconstituted Complex Homo sapiens
83 FLT1 2321
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
84 PML 5371
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
85 ITK 3702
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
86 TGM1 7051
Affinity Capture-MS Homo sapiens
87 FYN 2534
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
88 SARNP 84324
Co-fractionation Homo sapiens
89 COPS7B 64708
Co-fractionation Homo sapiens
90 GAREM  
Affinity Capture-MS Homo sapiens
91 PICALM 8301
Reconstituted Complex Homo sapiens
92 PECAM1 5175
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
93 BAG3 9531
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
94 DISC1 27185
Affinity Capture-MS Homo sapiens
95 DOK2 9046
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 LAT 27040
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
97 RNF40 9810
Co-fractionation Homo sapiens
98 RASA1 5921
Affinity Capture-Western Homo sapiens
99 ARHGAP32  
Affinity Capture-Western Homo sapiens
100 PYGB 5834
Co-fractionation Homo sapiens
101 CBFA2T3  
Affinity Capture-MS Homo sapiens
102 COPS7A 50813
Co-fractionation Homo sapiens
103 CD22 933
Affinity Capture-Western Homo sapiens
104 TIPRL 261726
Co-fractionation Homo sapiens
105 PTPN6 5777
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
106 DOCK7 85440
Co-fractionation Homo sapiens
107 CCDC120  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 LCP2 3937
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
109 ZFR 51663
Co-fractionation Homo sapiens
110 PDGFRA 5156
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
111 COPS8 10920
Co-fractionation Homo sapiens
112 UBR7  
Co-fractionation Homo sapiens
113 ERBB4 2066
Reconstituted Complex Homo sapiens
114 PRKD1 5587
Affinity Capture-Western Homo sapiens
115 EGFR 1956
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
116 SEC23A 10484
Co-fractionation Homo sapiens
117 PTK2 5747
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
118 LAT2 7462
Affinity Capture-Western Homo sapiens
119 DPP7 29952
Co-fractionation Homo sapiens
120 BASP1 10409
Co-fractionation Homo sapiens
121 GTF3C4 9329
Co-fractionation Homo sapiens
122 GAB1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
123 NXF1 10482
Affinity Capture-RNA Homo sapiens
124 STRAP 11171
Co-fractionation Homo sapiens
125 LZTS2 84445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 FGFR2 2263
Co-localization Homo sapiens
127 DGKZ  
Affinity Capture-Western Homo sapiens
128 ADD1 118
Co-fractionation Homo sapiens
129 PTPRJ 5795
Biochemical Activity Homo sapiens
130 MCMBP 79892
Co-fractionation Homo sapiens
131 NPEPL1 79716
Co-fractionation Homo sapiens
132 SPRY1 10252
Affinity Capture-Western Homo sapiens
133 MICALL1 85377
Affinity Capture-MS Homo sapiens
134 MET 4233
Reconstituted Complex Homo sapiens
135 DNAJC3 5611
Co-fractionation Homo sapiens
136 FEM1A  
Affinity Capture-MS Homo sapiens
137 TXNDC5 81567
Co-fractionation Homo sapiens
138 AKT1 207
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
139 COPS3 8533
Co-fractionation Homo sapiens
140 LMNA 4000
Co-fractionation Homo sapiens
141 KCNJ5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 PIK3R1 5295
Co-fractionation Homo sapiens
143 KIAA1522 57648
Affinity Capture-MS Homo sapiens
144 COPS2 9318
Co-fractionation Homo sapiens
145 GSN 2934
Reconstituted Complex Homo sapiens
146 PDGFA 5154
Affinity Capture-Western Homo sapiens
147 PLXNB2 23654
Affinity Capture-Western Homo sapiens
148 FASN 2194
Negative Genetic Homo sapiens
149 ZNF785  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 MTPN 136319
Affinity Capture-MS Homo sapiens
151 HEXA 3073
Co-fractionation Homo sapiens
152 GRB2 2885
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
153 THUMPD3 25917
Co-fractionation Homo sapiens
154 TP53 7157
Affinity Capture-MS Homo sapiens
155 EHD4 30844
Co-fractionation Homo sapiens
156 NTRK2 4915
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
157 EPHB2 2048
Two-hybrid Homo sapiens
158 SH2B3  
Affinity Capture-Western Homo sapiens
159 IRS2 8660
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
160 PAK1 5058
Reconstituted Complex Homo sapiens
161 ABL1 25
Reconstituted Complex Homo sapiens
162 INSR 3643
Protein-peptide Homo sapiens
163 TUB  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
164 C19orf25  
Affinity Capture-MS Homo sapiens
165 EPB41L2 2037
Co-fractionation Homo sapiens
166 WAS 7454
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
167 HNRNPK 3190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
168 RNF7  
Affinity Capture-MS Homo sapiens
169 LTK 4058
Affinity Capture-Western Homo sapiens
170 KHDRBS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
171 DOK1 1796
Reconstituted Complex Homo sapiens
172 XPO5 57510
Co-fractionation Homo sapiens
173 RPL38 6169
Co-fractionation Homo sapiens
174 MT1F  
Affinity Capture-MS Homo sapiens
175 ERRFI1 54206
Affinity Capture-MS Homo sapiens
176 IBTK 25998
Affinity Capture-Western Homo sapiens
177 RAB11A 8766
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
178 LIMD1 8994
Co-fractionation Homo sapiens
179 TNK1  
Reconstituted Complex Homo sapiens
180 SOS2 6655
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
181 GHR  
Reconstituted Complex Homo sapiens
182 GNB2L1 10399
Far Western Homo sapiens
183 AR 367
Reconstituted Complex Homo sapiens
184 BLNK  
Affinity Capture-Western Homo sapiens
185 GAS2L1 10634
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
186 RPA3 6119
Proximity Label-MS Homo sapiens
187 CAV1 857
Affinity Capture-Western Homo sapiens
188 NUDT5 11164
Co-fractionation Homo sapiens
189 EP300 2033
Affinity Capture-MS Homo sapiens
190 ATP5A1 498
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which PLCG1 is involved
PathwayEvidenceSource
Activated NTRK2 signals through PLCG1 IEA Reactome
Activated NTRK2 signals through PLCG1 TAS Reactome
Activated NTRK3 signals through PLCG1 IEA Reactome
Activated NTRK3 signals through PLCG1 TAS Reactome
Adaptive Immune System TAS Reactome
Anti-inflammatory response favouring Leishmania parasite infection TAS Reactome
Antiviral mechanism by IFN-stimulated genes TAS Reactome
Axon guidance IEA Reactome
Axon guidance TAS Reactome
Cell surface interactions at the vascular wall TAS Reactome
Constitutive Signaling by EGFRvIII TAS Reactome
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
DAG and IP3 signaling IEA Reactome
DAP12 interactions TAS Reactome
DAP12 signaling TAS Reactome
Developmental Biology IEA Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downstream signal transduction TAS Reactome
Downstream signaling of activated FGFR1 TAS Reactome
Downstream signaling of activated FGFR2 TAS Reactome
Downstream signaling of activated FGFR3 TAS Reactome
Downstream signaling of activated FGFR4 TAS Reactome
EGFR interacts with phospholipase C-gamma TAS Reactome
Erythropoietin activates Phospholipase C gamma (PLCG) IEA Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
Fc epsilon receptor (FCERI) signaling IEA Reactome
FCERI mediated Ca+2 mobilization IEA Reactome
FCERI mediated Ca+2 mobilization TAS Reactome
FCERI mediated MAPK activation TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis IEA Reactome
FCGR3A-mediated IL10 synthesis TAS Reactome
Generation of second messenger molecules TAS Reactome
Hemostasis TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Inositol phosphate metabolism TAS Reactome
Interferon Signaling TAS Reactome
Intracellular signaling by second messengers IEA Reactome
ISG15 antiviral mechanism TAS Reactome
Leishmania infection TAS Reactome
Leishmania parasite growth and survival TAS Reactome
Metabolism TAS Reactome
Nervous system development IEA Reactome
Nervous system development TAS Reactome
Netrin-1 signaling IEA Reactome
Parasitic Infection Pathways TAS Reactome
PECAM1 interactions TAS Reactome
Phospholipase C-mediated cascade: FGFR1 TAS Reactome
Phospholipase C-mediated cascade; FGFR2 TAS Reactome
Phospholipase C-mediated cascade; FGFR3 TAS Reactome
Phospholipase C-mediated cascade; FGFR4 TAS Reactome
PLC-gamma1 signalling IEA Reactome
PLCG1 events in ERBB2 signaling IEA Reactome
RET signaling TAS Reactome
Role of phospholipids in phagocytosis TAS Reactome
Role of phospholipids in phagocytosis IEA Reactome
Role of second messengers in netrin-1 signaling IEA Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Signaling by ALK TAS Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
Signaling by EGFR TAS Reactome
Signaling by EGFR in Cancer TAS Reactome
Signaling by EGFRvIII in Cancer TAS Reactome
Signaling by ERBB2 IEA Reactome
Signaling by ERBB2 ECD mutants TAS Reactome
Signaling by ERBB2 in Cancer TAS Reactome
Signaling by ERBB2 KD Mutants TAS Reactome
Signaling by ERBB2 TMD/JMD mutants TAS Reactome
Signaling by Erythropoietin IEA Reactome
Signaling by FGFR TAS Reactome
Signaling by FGFR in disease TAS Reactome
Signaling by FGFR1 TAS Reactome
Signaling by FGFR1 in disease TAS Reactome
Signaling by FGFR2 TAS Reactome
Signaling by FGFR2 in disease TAS Reactome
Signaling by FGFR3 TAS Reactome
Signaling by FGFR3 in disease TAS Reactome
Signaling by FGFR4 TAS Reactome
Signaling by FGFR4 in disease TAS Reactome
Signaling by Ligand-Responsive EGFR Variants in Cancer TAS Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRK2 (TRKB) IEA Reactome
Signaling by NTRK2 (TRKB) TAS Reactome
Signaling by NTRK3 (TRKC) IEA Reactome
Signaling by NTRK3 (TRKC) TAS Reactome
Signaling by NTRKs IEA Reactome
Signaling by NTRKs TAS Reactome
Signaling by PDGF TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by VEGF TAS Reactome
Signaling by VEGF IEA Reactome
Synthesis of IP3 and IP4 in the cytosol TAS Reactome
TCR signaling TAS Reactome
VEGFA-VEGFR2 Pathway TAS Reactome
VEGFA-VEGFR2 Pathway IEA Reactome
VEGFR2 mediated cell proliferation TAS Reactome
VEGFR2 mediated cell proliferation IEA Reactome





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