Gene description for FYN
Gene name FYN proto-oncogene, Src family tyrosine kinase
Gene symbol FYN
Other names/aliases SLK
SYN
p59-FYN
Species Homo sapiens
 Database cross references - FYN
ExoCarta ExoCarta_2534
Vesiclepedia VP_2534
Entrez Gene 2534
HGNC 4037
MIM 137025
UniProt P06241  
 FYN identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Embryonic kidney cells 36706192    
Embryonic kidney cells 36706192    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Thymus 23844026    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for FYN
Molecular Function
    G protein-coupled receptor binding GO:0001664 IPI
    protein tyrosine kinase activity GO:0004713 EXP
    protein tyrosine kinase activity GO:0004713 IDA
    protein tyrosine kinase activity GO:0004713 IMP
    protein tyrosine kinase activity GO:0004713 ISS
    protein tyrosine kinase activity GO:0004713 TAS
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 NAS
    signaling receptor binding GO:0005102 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    phospholipase activator activity GO:0016004 IDA
    enzyme binding GO:0019899 IPI
    type 5 metabotropic glutamate receptor binding GO:0031802 ISS
    histone H3Y41 kinase activity GO:0035401 IEA
    identical protein binding GO:0042802 IPI
    alpha-tubulin binding GO:0043014 ISS
    phospholipase binding GO:0043274 IPI
    transmembrane transporter binding GO:0044325 IEA
    metal ion binding GO:0046872 IEA
    ephrin receptor binding GO:0046875 IPI
    tau protein binding GO:0048156 ISS
    tau protein binding GO:0048156 NAS
    tau protein binding GO:0048156 TAS
    tau-protein kinase activity GO:0050321 NAS
    growth factor receptor binding GO:0070851 IPI
    scaffold protein binding GO:0097110 IPI
    disordered domain specific binding GO:0097718 IPI
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    response to singlet oxygen GO:0000304 ISS
    neuron migration GO:0001764 IEA
    stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS
    adaptive immune response GO:0002250 IEA
    negative regulation of inflammatory response to antigenic stimulus GO:0002862 TAS
    heart process GO:0003015 IGI
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 NAS
    calcium ion transport GO:0006816 NAS
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    G protein-coupled glutamate receptor signaling pathway GO:0007216 IDA
    axon guidance GO:0007411 TAS
    learning GO:0007612 TAS
    feeding behavior GO:0007631 TAS
    regulation of cell shape GO:0008360 ISS
    gene expression GO:0010467 IEA
    negative regulation of gene expression GO:0010629 IEA
    negative regulation of hydrogen peroxide biosynthetic process GO:0010730 ISS
    positive regulation of neuron projection development GO:0010976 IEA
    negative regulation of angiogenesis GO:0016525 IEA
    protein ubiquitination GO:0016567 IEA
    peptidyl-tyrosine phosphorylation GO:0018108 IMP
    peptidyl-tyrosine phosphorylation GO:0018108 ISS
    natural killer cell activation GO:0030101 IDA
    cell differentiation GO:0030154 IBA
    protein catabolic process GO:0030163 IEA
    forebrain development GO:0030900 IEA
    T cell costimulation GO:0031295 TAS
    negative regulation of protein ubiquitination GO:0031397 IEA
    intracellular signal transduction GO:0035556 IDA
    cellular response to platelet-derived growth factor stimulus GO:0036120 IEA
    reelin-mediated signaling pathway GO:0038026 ISS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    negative regulation of protein catabolic process GO:0042177 IEA
    response to ethanol GO:0045471 IEA
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    ephrin receptor signaling pathway GO:0048013 TAS
    dendrite morphogenesis GO:0048813 IEA
    regulation of peptidyl-tyrosine phosphorylation GO:0050730 ISS
    activated T cell proliferation GO:0050798 IEA
    modulation of chemical synaptic transmission GO:0050804 IEA
    T cell receptor signaling pathway GO:0050852 IBA
    T cell receptor signaling pathway GO:0050852 IDA
    leukocyte migration GO:0050900 TAS
    detection of mechanical stimulus involved in sensory perception of pain GO:0050966 IEA
    cellular response to hydrogen peroxide GO:0070301 ISS
    cellular response to transforming growth factor beta stimulus GO:0071560 IEA
    positive regulation of protein targeting to membrane GO:0090314 ISS
    dendritic spine maintenance GO:0097062 TAS
    positive regulation of protein localization to nucleus GO:1900182 IEA
    regulation of glutamate receptor signaling pathway GO:1900449 ISS
    negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 ISS
    negative regulation of dendritic spine maintenance GO:1902951 ISS
    response to amyloid-beta GO:1904645 ISS
    cellular response to amyloid-beta GO:1904646 IMP
    cellular response to L-glutamate GO:1905232 ISS
    cellular response to glycine GO:1905430 ISS
    positive regulation of protein localization to membrane GO:1905477 TAS
    regulation of calcium ion import across plasma membrane GO:1905664 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
    mitochondrion GO:0005739 ISS
    endosome GO:0005768 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    actin filament GO:0005884 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    postsynaptic density GO:0014069 ISS
    dendrite GO:0030425 IDA
    dendrite GO:0030425 ISS
    perikaryon GO:0043204 IEA
    cell body GO:0044297 ISS
    membrane raft GO:0045121 IDA
    membrane raft GO:0045121 IDA
    membrane raft GO:0045121 IMP
    membrane raft GO:0045121 ISS
    membrane raft GO:0045121 TAS
    perinuclear region of cytoplasm GO:0048471 ISS
    perinuclear endoplasmic reticulum GO:0097038 ISS
    glial cell projection GO:0097386 ISS
    Schaffer collateral - CA1 synapse GO:0098685 IEA
 Experiment description of studies that identified FYN in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
9
Experiment ID 1275
MISEV standards
Biophysical techniques
✔
CD9|TSG101|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 1280
MISEV standards
Biophysical techniques
✔
TSG101|CD9|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T - Fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density 1.151 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 254
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name MNT-1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 255
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name G1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 256
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 501mel
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 257
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 258
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 259
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 260
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
22
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
23
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
24
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
25
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
26
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
27
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
28
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
29
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
30
Experiment ID 196
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
31
Experiment ID 197
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FYN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 SIAH1  
Affinity Capture-MS Homo sapiens
3 FRK 2444
Affinity Capture-Western Homo sapiens
4 Mtx1  
Affinity Capture-MS Mus musculus
5 LRRIQ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 KIF23 9493
Affinity Capture-MS Homo sapiens
7 CPNE9  
Affinity Capture-MS Homo sapiens
8 FAS 355
Affinity Capture-Western Homo sapiens
9 PRKCD 5580
Co-localization Homo sapiens
10 CSK 1445
Affinity Capture-Western Homo sapiens
11 DAG1 1605
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
12 PTPN5  
Affinity Capture-Western Homo sapiens
13 MAGEE1  
Affinity Capture-MS Homo sapiens
14 HOXA9  
Affinity Capture-MS Homo sapiens
15 EFS  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
16 HRAS 3265
Reconstituted Complex Homo sapiens
17 KIF20A 10112
Affinity Capture-MS Homo sapiens
18 C1orf226  
Affinity Capture-MS Homo sapiens
19 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
20 TRMT6 51605
Affinity Capture-MS Homo sapiens
21 TRIM55  
Two-hybrid Homo sapiens
22 FAM135B  
Affinity Capture-MS Homo sapiens
23 SUV39H1  
Two-hybrid Homo sapiens
24 SOX2  
Affinity Capture-MS Homo sapiens
25 FYB 2533
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
26 EPHA8  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
27 YES1 7525
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 WAS 7454
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
29 C2orf73  
Affinity Capture-MS Homo sapiens
30 PLCG2 5336
Reconstituted Complex Homo sapiens
31 SDC3  
Reconstituted Complex Homo sapiens
32 Nedd4 25489
Biochemical Activity Rattus norvegicus
33 TSNAX 7257
Affinity Capture-MS Homo sapiens
34 ZAP70 7535
Phenotypic Enhancement Homo sapiens
Affinity Capture-Western Homo sapiens
35 SRSF10 10772
Affinity Capture-MS Homo sapiens
36 CD2 914
Reconstituted Complex Homo sapiens
37 SRC 6714
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ERGIC1 57222
Proximity Label-MS Homo sapiens
39 KHDRBS1 10657
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
40 SYK 6850
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
41 FAM206A  
Affinity Capture-MS Homo sapiens
42 SLAMF1 6504
Reconstituted Complex Homo sapiens
43 MTUS2 23281
Affinity Capture-MS Homo sapiens
44 PLCG1 5335
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
45 ABCE1 6059
Affinity Capture-MS Homo sapiens
46 Efs  
Reconstituted Complex Mus musculus
Reconstituted Complex Mus musculus
47 TOM1L1 10040
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
48 PRKCI 5584
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 CES2 8824
Affinity Capture-MS Homo sapiens
50 TEX19  
Affinity Capture-MS Homo sapiens
51 TMTC4  
Affinity Capture-MS Homo sapiens
52 PRMT6  
Two-hybrid Homo sapiens
53 TUBA3C 7278
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
54 RPS6KA1 6195
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 Mbp 17196
Protein-peptide Mus musculus
56 SKAP2 8935
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
57 LIMK1 3984
Affinity Capture-MS Homo sapiens
58 RPS6KA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 ANAPC16  
Affinity Capture-MS Homo sapiens
60 NMT1 4836
Biochemical Activity Homo sapiens
61 SDCBP 6386
Affinity Capture-MS Homo sapiens
62 DHCR24 1718
Affinity Capture-MS Homo sapiens
63 NEDD4 4734
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
64 ACVR1 90
Affinity Capture-MS Homo sapiens
65 KCNA4  
Affinity Capture-Western Homo sapiens
66 KIF14 9928
Affinity Capture-MS Homo sapiens
67 MAP2 4133
Affinity Capture-Western Homo sapiens
68 TNF  
Reconstituted Complex Homo sapiens
69 Mta1  
Reconstituted Complex Mus musculus
Reconstituted Complex Mus musculus
70 NEDD9 4739
Affinity Capture-Western Homo sapiens
71 HSP90AB4P 664618
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 BCAR1 9564
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
73 MYO18A 399687
Affinity Capture-MS Homo sapiens
74 KIT 3815
Affinity Capture-Western Homo sapiens
75 FASLG 356
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
76 VAV1 7409
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
77 KCNC3 3748
Affinity Capture-MS Homo sapiens
78 VAV2 7410
Two-hybrid Homo sapiens
79 RPS6KA3 6197
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 Mta3  
Reconstituted Complex Mus musculus
81 POLR3K  
Affinity Capture-MS Homo sapiens
82 IFITM3 10410
Affinity Capture-Western Homo sapiens
83 NPHS1 4868
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
84 NR3C1 2908
Affinity Capture-Western Homo sapiens
85 COPG1 22820
Affinity Capture-MS Homo sapiens
86 JAK2 3717
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
87 MAPRE1 22919
Affinity Capture-MS Homo sapiens
88 MCAM 4162
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
89 CBL 867
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
90 ATP6V1C2 245973
Affinity Capture-MS Homo sapiens
91 CERS2 29956
Affinity Capture-MS Homo sapiens
92 GJB7  
Affinity Capture-MS Homo sapiens
93 PAG1 55824
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
94 ADD2 119
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
95 GID8 54994
Affinity Capture-MS Homo sapiens
96 SSH1  
Affinity Capture-MS Homo sapiens
97 CDH1 999
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
98 CHMP4B 128866
Affinity Capture-MS Homo sapiens
99 FYN 2534
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
100 MYH9 4627
Affinity Capture-MS Homo sapiens
101 SH2D1A 4068
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
102 PTK2B 2185
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
103 SLC4A8 9498
Affinity Capture-MS Homo sapiens
104 MKRN2 23609
Affinity Capture-RNA Homo sapiens
105 KCNA5  
Affinity Capture-Western Homo sapiens
106 UNC119 9094
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
107 ENO1 2023
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
108 TMEM192 201931
Affinity Capture-MS Homo sapiens
109 ITK 3702
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
110 BTK 695
Reconstituted Complex Homo sapiens
111 GRIN2A  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
112 CTNNA3  
Affinity Capture-MS Homo sapiens
113 FGFR1OP2  
Affinity Capture-MS Homo sapiens
114 ITCH 83737
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
115 ELOVL5 60481
Proximity Label-MS Homo sapiens
116 HAUS7  
Affinity Capture-MS Homo sapiens
117 SSX3  
Affinity Capture-MS Homo sapiens
118 TRIM63  
Two-hybrid Homo sapiens
119 PDE4D  
Far Western Homo sapiens
120 TCAP  
Two-hybrid Homo sapiens
121 TMEM185A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 ATXN1 6310
Two-hybrid Homo sapiens
124 PRRG4  
Reconstituted Complex Homo sapiens
125 LAT 27040
Biochemical Activity Homo sapiens
126 PTPN11 5781
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
127 ARHGAP32  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
128 PMS2  
Affinity Capture-MS Homo sapiens
129 Myh9 17886
Affinity Capture-MS Mus musculus
130 STRN3 29966
Affinity Capture-MS Homo sapiens
131 Ptpra 19262
Biochemical Activity Mus musculus
132 ATP5F1 515
Affinity Capture-MS Homo sapiens
133 PANX1 24145
Proximity Label-MS Homo sapiens
134 NDFIP2 54602
Affinity Capture-Western Homo sapiens
135 ECT2 1894
Affinity Capture-MS Homo sapiens
136 PECAM1 5175
Affinity Capture-Western Homo sapiens
137 HOXB5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 CMA1  
Protein-peptide Homo sapiens
139 AKAP9 10142
Affinity Capture-Western Homo sapiens
140 CTNNB1 1499
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
141 SOCS1  
Reconstituted Complex Homo sapiens
142 PTPRA 5786
Affinity Capture-Western Homo sapiens
143 PCDHGC3 5098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 TNFRSF1A 7132
Co-fractionation Homo sapiens
145 TRAF6 7189
Reconstituted Complex Homo sapiens
146 ARNT 405
Affinity Capture-MS Homo sapiens
147 TMEM204  
Affinity Capture-MS Homo sapiens
148 UHRF2  
Far Western Homo sapiens
149 Pde4d  
Affinity Capture-Western Rattus norvegicus
150 HSP90AB3P 3327
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 DLG4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
152 SLC25A41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 TYK2 7297
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
154 CD3G 917
Affinity Capture-Western Homo sapiens
155 CD226 10666
Affinity Capture-Western Homo sapiens
156 GRIN1 2902
Biochemical Activity Homo sapiens
157 SH3BP2  
Two-hybrid Homo sapiens
158 PRKCQ 5588
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
159 FGFR2 2263
Affinity Capture-Western Homo sapiens
160 HSP90AA4P 3323
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 CD5 921
Affinity Capture-Western Homo sapiens
162 IL7R  
Affinity Capture-Western Homo sapiens
163 PTK2 5747
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
164 TMEM132A 54972
Affinity Capture-MS Homo sapiens
165 SMAD2 4087
Affinity Capture-MS Homo sapiens
166 GRIN2B  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
167 PDE4DIP 9659
Affinity Capture-Western Homo sapiens
168 RPL10 6134
Reconstituted Complex Homo sapiens
169 CD244 51744
Affinity Capture-Western Homo sapiens
170 RAF1 5894
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
171 SIT1 27240
Affinity Capture-Western Homo sapiens
172 MAK16  
Affinity Capture-MS Homo sapiens
173 PRUNE2  
Affinity Capture-MS Homo sapiens
174 TRPC6 7225
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
175 CAB39L 81617
Affinity Capture-MS Homo sapiens
176 TRPV4 59341
Affinity Capture-Western Homo sapiens
177 BIRC8  
Affinity Capture-MS Homo sapiens
178 CLDN20  
Affinity Capture-MS Homo sapiens
179 EPHB3 2049
Reconstituted Complex Homo sapiens
180 CSF1R  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
181 THY1 7070
Affinity Capture-Western Homo sapiens
182 GNB2L1 10399
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
183 SUPT20H 55578
Affinity Capture-MS Homo sapiens
184 MALL  
Affinity Capture-MS Homo sapiens
185 CCDC8  
Affinity Capture-MS Homo sapiens
186 TNNT1  
Two-hybrid Homo sapiens
187 CBLC  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
188 GATAD2A 54815
Affinity Capture-MS Homo sapiens
189 Coro1c 23790
Affinity Capture-MS Mus musculus
190 CDK5RAP2 55755
Affinity Capture-Western Homo sapiens
191 SNCA 6622
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
192 TNK2 10188
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
193 C8orf33 65265
Two-hybrid Homo sapiens
194 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
195 SLC25A11 8402
Affinity Capture-MS Homo sapiens
196 GRASP  
Biochemical Activity Homo sapiens
197 ZNFX1 57169
Affinity Capture-MS Homo sapiens
198 MAPT  
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
199 GAB3  
Reconstituted Complex Homo sapiens
200 CLTC 1213
Biochemical Activity Homo sapiens
201 Sod1 20655
Affinity Capture-MS Mus musculus
202 Osgep  
Affinity Capture-MS Mus musculus
203 PTPRD 5789
Affinity Capture-MS Homo sapiens
204 NTRK2 4915
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
205 WBP11  
Two-hybrid Homo sapiens
206 ANKRD12  
Affinity Capture-MS Homo sapiens
207 EPHA4 2043
Affinity Capture-Western Homo sapiens
208 AMHR2  
Affinity Capture-MS Homo sapiens
209 IL1B  
Reconstituted Complex Homo sapiens
210 IKBKG 8517
Affinity Capture-Western Homo sapiens
211 GRB10 2887
Biochemical Activity Homo sapiens
212 MS4A1 931
Affinity Capture-Western Homo sapiens
213 TRAT1 50852
Reconstituted Complex Homo sapiens
214 SOS1 6654
Reconstituted Complex Homo sapiens
215 MRAP2  
Affinity Capture-MS Homo sapiens
216 GRM1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
217 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
218 PIK3R1 5295
Reconstituted Complex Homo sapiens
219 ADAM15 8751
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
220 PRKACA 5566
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
221 CDK1 983
Affinity Capture-Western Homo sapiens
222 CTLA4  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
223 CD36 948
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
224 MAG  
Reconstituted Complex Homo sapiens
225 EPHA3 2042
Reconstituted Complex Homo sapiens
226 SKAP1 8631
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
227 TNFRSF10B 8795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
228 MED21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
229 KDM1A 23028
Two-hybrid Homo sapiens
230 BCL3  
Reconstituted Complex Homo sapiens
231 TMEM257  
Affinity Capture-MS Homo sapiens
232 RNF31 55072
Affinity Capture-MS Homo sapiens
233 CCNL2 81669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
234 MND1  
Affinity Capture-MS Homo sapiens
235 PXN 5829
Affinity Capture-Western Homo sapiens
236 ERRFI1 54206
Affinity Capture-MS Homo sapiens
237 PRKAR1A 5573
Affinity Capture-MS Homo sapiens
238 SH3KBP1 30011
Affinity Capture-Western Homo sapiens
239 ASCL4  
Affinity Capture-MS Homo sapiens
240 GRSF1 2926
Two-hybrid Homo sapiens
241 ACBD7  
Affinity Capture-MS Homo sapiens
242 PIK3R2 5296
Reconstituted Complex Homo sapiens
243 C7orf25  
Two-hybrid Homo sapiens
244 CD44 960
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
245 Flnb 286940
Affinity Capture-MS Mus musculus
246 GP6 51206
Reconstituted Complex Homo sapiens
247 KCNA2  
Affinity Capture-Western Homo sapiens
248 ALS2CR12  
Affinity Capture-MS Homo sapiens
249 CAV1 857
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
250 KCNA3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
251 CDC37 11140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
252 CHRNA7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
253 CTNND1 1500
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
254 MED28  
Affinity Capture-Western Homo sapiens
255 Trim69  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which FYN is involved
PathwayEvidenceSource
Activated NTRK2 signals through FYN IEA Reactome
Activated NTRK2 signals through FYN TAS Reactome
Adaptive Immune System TAS Reactome
Adaptive Immune System IEA Reactome
Anti-inflammatory response favouring Leishmania parasite infection TAS Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IEA Reactome
Axon guidance TAS Reactome
Axon guidance IEA Reactome
C-type lectin receptors (CLRs) TAS Reactome
CD209 (DC-SIGN) signaling TAS Reactome
CD28 co-stimulation TAS Reactome
CD28 dependent PI3K/Akt signaling TAS Reactome
CD28 dependent Vav1 pathway TAS Reactome
Cell surface interactions at the vascular wall TAS Reactome
Cell-Cell communication TAS Reactome
Cell-Cell communication IEA Reactome
Cellular responses to mechanical stimuli IEA Reactome
Cellular responses to stimuli IEA Reactome
Constitutive Signaling by Aberrant PI3K in Cancer TAS Reactome
Costimulation by the CD28 family TAS Reactome
CRMPs in Sema3A signaling IEA Reactome
CRMPs in Sema3A signaling TAS Reactome
CTLA4 inhibitory signaling TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
Cytokine Signaling in Immune system TAS Reactome
DAP12 interactions TAS Reactome
DAP12 interactions IEA Reactome
DAP12 signaling TAS Reactome
DAP12 signaling IEA Reactome
DCC mediated attractive signaling TAS Reactome
DCC mediated attractive signaling IEA Reactome
Dectin-2 family TAS Reactome
Developmental Biology TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
EPH-ephrin mediated repulsion of cells TAS Reactome
EPH-Ephrin signaling TAS Reactome
EPH-Ephrin signaling IEA Reactome
EPHA-mediated growth cone collapse TAS Reactome
EPHA-mediated growth cone collapse IEA Reactome
EPHB-mediated forward signaling TAS Reactome
EPHB-mediated forward signaling IEA Reactome
Ephrin signaling TAS Reactome
Ephrin signaling IEA Reactome
Fc epsilon receptor (FCERI) signaling IEA Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
FCGR activation TAS Reactome
FCGR3A-mediated IL10 synthesis TAS Reactome
FCGR3A-mediated phagocytosis TAS Reactome
FLT3 Signaling IEA Reactome
FLT3 signaling through SRC family kinases IEA Reactome
GPVI-mediated activation cascade TAS Reactome
Hemostasis TAS Reactome
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells IEA Reactome
HIV Infection TAS Reactome
Host Interactions of HIV factors TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling IEA Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling TAS Reactome
Intracellular signaling by second messengers TAS Reactome
Leishmania infection TAS Reactome
Leishmania parasite growth and survival TAS Reactome
Leishmania phagocytosis TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
NCAM signaling for neurite out-growth IEA Reactome
NCAM signaling for neurite out-growth TAS Reactome
Nef and signal transduction TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
Nephrin family interactions TAS Reactome
Nephrin family interactions IEA Reactome
Nervous system development TAS Reactome
Nervous system development IEA Reactome
Netrin-1 signaling TAS Reactome
Netrin-1 signaling IEA Reactome
NTRK2 activates RAC1 IEA Reactome
NTRK2 activates RAC1 TAS Reactome
Parasite infection TAS Reactome
Parasitic Infection Pathways TAS Reactome
PECAM1 interactions TAS Reactome
PI3K/AKT Signaling in Cancer TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet Adhesion to exposed collagen TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Reelin signalling pathway TAS Reactome
Regulation of KIT signaling TAS Reactome
Regulation of signaling by CBL IEA Reactome
Regulation of signaling by CBL TAS Reactome
Response of endothelial cells to shear stress IEA Reactome
Role of LAT2/NTAL/LAB on calcium mobilization IEA Reactome
Sema3A PAK dependent Axon repulsion TAS Reactome
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion IEA Reactome
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion TAS Reactome
Semaphorin interactions IEA Reactome
Semaphorin interactions TAS Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Signaling by CSF1 (M-CSF) in myeloid cells IEA Reactome
Signaling by ERBB2 TAS Reactome
Signaling by Interleukins IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by KIT in disease TAS Reactome
Signaling by NTRK2 (TRKB) IEA Reactome
Signaling by NTRK2 (TRKB) TAS Reactome
Signaling by NTRKs IEA Reactome
Signaling by NTRKs TAS Reactome
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by SCF-KIT IEA Reactome
Signaling by SCF-KIT TAS Reactome
Signaling by the B Cell Receptor (BCR) IEA Reactome
Signaling by VEGF TAS Reactome
The role of Nef in HIV-1 replication and disease pathogenesis TAS Reactome
VEGFA-VEGFR2 Pathway TAS Reactome
Viral Infection Pathways TAS Reactome





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