Gene description for ACVR1
Gene name activin A receptor, type I
Gene symbol ACVR1
Other names/aliases ACTRI
ACVR1A
ACVRLK2
ALK2
FOP
SKR1
TSRI
Species Homo sapiens
 Database cross references - ACVR1
ExoCarta ExoCarta_90
Vesiclepedia VP_90
Entrez Gene 90
HGNC 171
MIM 102576
UniProt Q04771  
 ACVR1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for ACVR1
Molecular Function
    protein kinase activity GO:0004672 IDA
    protein serine/threonine kinase activity GO:0004674 IDA
    transmembrane receptor protein serine/threonine kinase activity GO:0004675 IDA
    transmembrane receptor protein serine/threonine kinase activity GO:0004675 NAS
    transforming growth factor beta receptor activity, type I GO:0005025 IBA
    transforming growth factor beta receptor activity, type II GO:0005026 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    activin receptor activity, type I GO:0016361 IDA
    activin receptor activity, type II GO:0016362 IEA
    peptide hormone binding GO:0017046 NAS
    protein homodimerization activity GO:0042803 IDA
    cadherin binding GO:0045296 IPI
    SMAD binding GO:0046332 IBA
    SMAD binding GO:0046332 IDA
    metal ion binding GO:0046872 IEA
    activin binding GO:0048185 IDA
    transforming growth factor beta binding GO:0050431 IDA
    transforming growth factor beta receptor activity, type III GO:0070123 IEA
    BMP receptor activity GO:0098821 IDA
    protein tyrosine kinase binding GO:1990782 IPI
Biological Process
    branching involved in blood vessel morphogenesis GO:0001569 IEA
    osteoblast differentiation GO:0001649 IDA
    in utero embryonic development GO:0001701 IEA
    gastrulation with mouth forming second GO:0001702 IEA
    mesoderm formation GO:0001707 IEA
    neural crest cell migration GO:0001755 IEA
    acute inflammatory response GO:0002526 IEA
    embryonic heart tube morphogenesis GO:0003143 IMP
    outflow tract septum morphogenesis GO:0003148 ISS
    atrioventricular valve morphogenesis GO:0003181 ISS
    mitral valve morphogenesis GO:0003183 IMP
    endocardial cushion formation GO:0003272 ISS
    endocardial cushion fusion GO:0003274 ISS
    atrial septum primum morphogenesis GO:0003289 IMP
    atrial septum primum morphogenesis GO:0003289 ISS
    transforming growth factor beta receptor signaling pathway GO:0007179 IBA
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    germ cell development GO:0007281 IEA
    determination of left/right symmetry GO:0007368 IEA
    heart development GO:0007507 IBA
    dorsal/ventral pattern formation GO:0009953 IBA
    negative regulation of signal transduction GO:0009968 IMP
    cell differentiation GO:0030154 IBA
    regulation of ossification GO:0030278 IMP
    positive regulation of cell migration GO:0030335 IGI
    positive regulation of bone mineralization GO:0030501 IMP
    BMP signaling pathway GO:0030509 IBA
    BMP signaling pathway GO:0030509 IDA
    BMP signaling pathway GO:0030509 ISS
    activin receptor signaling pathway GO:0032924 IDA
    activin receptor signaling pathway GO:0032924 IMP
    negative regulation of activin receptor signaling pathway GO:0032926 IMP
    positive regulation of osteoblast differentiation GO:0045669 IMP
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IMP
    smooth muscle cell differentiation GO:0051145 IEA
    pharyngeal system development GO:0060037 IEA
    positive regulation of SMAD protein signal transduction GO:0060391 IDA
    positive regulation of SMAD protein signal transduction GO:0060391 ISS
    ventricular septum morphogenesis GO:0060412 ISS
    cardiac muscle cell fate commitment GO:0060923 IMP
    endocardial cushion cell fate commitment GO:0061445 IMP
    positive regulation of cardiac epithelial to mesenchymal transition GO:0062043 ISS
    cellular response to growth factor stimulus GO:0071363 IBA
    cellular response to BMP stimulus GO:0071773 IMP
    positive regulation of determination of dorsal identity GO:2000017 IDA
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IMP
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IMP
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    apical part of cell GO:0045177 IEA
    activin receptor complex GO:0048179 IDA
    BMP receptor complex GO:0070724 IBA
 Experiment description of studies that identified ACVR1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 260
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ACVR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 AXL 558
Affinity Capture-MS Homo sapiens
3 LRRIQ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 GDF2 2658
Reconstituted Complex Homo sapiens
5 Ap2b1 71770
Affinity Capture-Luminescence Mus musculus
6 NRSN1  
Affinity Capture-MS Homo sapiens
7 BAMBI  
Reconstituted Complex Homo sapiens
8 Rab3b  
Affinity Capture-Luminescence Mus musculus
9 GRAMD1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 Fkbp4 14228
Affinity Capture-Luminescence Mus musculus
11 INSRR 3645
Affinity Capture-MS Homo sapiens
12 Rhoj  
Affinity Capture-Luminescence Mus musculus
13 ACVR2B  
Affinity Capture-MS Homo sapiens
14 GDF5 8200
Affinity Capture-Western Homo sapiens
15 EDAR  
Affinity Capture-MS Homo sapiens
16 SMAD5 4090
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
17 Rab6b  
Affinity Capture-Luminescence Mus musculus
18 ERBB2 2064
Affinity Capture-MS Homo sapiens
19 Nras 18176
Affinity Capture-Luminescence Mus musculus
20 Usp21  
Affinity Capture-Luminescence Mus musculus
21 Nkiras1  
Affinity Capture-Luminescence Mus musculus
22 ACVR1 90
FRET Homo sapiens
FRET Homo sapiens
23 KCNK18  
Affinity Capture-MS Homo sapiens
24 Rhebl1  
Affinity Capture-Luminescence Mus musculus
25 ACVR1B 91
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 Fancl  
Affinity Capture-Luminescence Mus musculus
27 FYN 2534
Affinity Capture-MS Homo sapiens
28 Wdr61  
Affinity Capture-Luminescence Mus musculus
29 Ube2r2  
Affinity Capture-Luminescence Mus musculus
30 BMP7 655
Reconstituted Complex Homo sapiens
31 Sqstm1  
Affinity Capture-Luminescence Mus musculus
32 TDGF1  
Reconstituted Complex Homo sapiens
33 MRAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 Ikbkb 16150
Affinity Capture-Luminescence Mus musculus
35 Fcho1  
Affinity Capture-Luminescence Mus musculus
36 INHBA 3624
Affinity Capture-Western Homo sapiens
37 TNFRSF10A 8797
Affinity Capture-MS Homo sapiens
38 Ajuba  
Affinity Capture-Luminescence Mus musculus
39 MYADM 91663
Affinity Capture-MS Homo sapiens
40 CD320 51293
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 Ube2e3  
Affinity Capture-Luminescence Mus musculus
42 USP15 9958
Affinity Capture-Western Homo sapiens
43 ACVRL1 94
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 IGSF1  
Affinity Capture-Western Homo sapiens
45 Plek  
Affinity Capture-Luminescence Mus musculus
46 ACVR2A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 Naa20  
Affinity Capture-Luminescence Mus musculus
48 Stat1 20846
Affinity Capture-Luminescence Mus musculus
49 SMAD1 4086
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
50 KCNE3  
Affinity Capture-MS Homo sapiens
51 Tgfbr1 21812
Affinity Capture-Luminescence Mus musculus
52 Stx8 55943
Affinity Capture-Luminescence Mus musculus
53 Ilkap  
Affinity Capture-Luminescence Mus musculus
54 FNTA 2339
Two-hybrid Homo sapiens
55 Rhobtb1  
Affinity Capture-Luminescence Mus musculus
56 Rap2a  
Affinity Capture-Luminescence Mus musculus
57 Rhod  
Affinity Capture-Luminescence Mus musculus
58 Fgd6  
Affinity Capture-Luminescence Mus musculus
59 Chn1  
Affinity Capture-Luminescence Mus musculus
60 SMAD6  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
61 Rab33b  
Affinity Capture-Luminescence Mus musculus
62 Plekhb1  
Affinity Capture-Luminescence Mus musculus
63 Nuak2  
Affinity Capture-Luminescence Mus musculus
64 Usp39  
Affinity Capture-Luminescence Mus musculus
65 Rps27a 78294
Affinity Capture-Luminescence Mus musculus
66 ARV1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 Cdk14  
Affinity Capture-Luminescence Mus musculus
68 TGFBR2 7048
Two-hybrid Homo sapiens
69 SMAD7  
Affinity Capture-Western Homo sapiens
70 TGFBRAP1 9392
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 Fbxo3  
Affinity Capture-Luminescence Mus musculus
72 Uhmk1  
Affinity Capture-Luminescence Mus musculus
73 Rab17  
Affinity Capture-Luminescence Mus musculus
74 OPALIN  
Affinity Capture-MS Homo sapiens
75 SMURF1 57154
Affinity Capture-Western Homo sapiens
76 BMPR1A 657
FRET Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 OTUB1 55611
Biochemical Activity Homo sapiens
78 FKBP1A 2280
Affinity Capture-Western Homo sapiens
79 Rras2 66922
Affinity Capture-Luminescence Mus musculus
80 MED16 10025
Affinity Capture-MS Homo sapiens
81 TNFRSF10B 8795
Affinity Capture-MS Homo sapiens
82 TSC22D1 8848
Affinity Capture-Western Homo sapiens
83 Rasd2  
Affinity Capture-Luminescence Mus musculus
84 RGMB  
Affinity Capture-Western Homo sapiens
85 BMPR2 659
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
86 ENG 2022
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which ACVR1 is involved
No pathways found





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