Gene description for GDF2
Gene name	growth differentiation factor 2
Gene symbol	GDF2
Other names/aliases	BMP-9 BMP9 HHT5
Species	Homo sapiens
Database cross references - GDF2
ExoCarta	ExoCarta_2658
Vesiclepedia	VP_2658
Entrez Gene	2658
HGNC	4217
MIM	605120
UniProt	Q9UK05
GDF2 identified in sEVs derived from the following tissue/cell type
Urine	19056867

Gene ontology annotations for GDF2

Molecular Function     cytokine activity GO:0005125 IBA     cytokine activity GO:0005125 IGI     protein binding GO:0005515 IPI     growth factor activity GO:0008083 IDA     protein serine/threonine kinase activator activity GO:0043539 IDA Biological Process     ossification GO:0001503 TAS     angiogenesis GO:0001525 IMP     branching involved in blood vessel morphogenesis GO:0001569 IDA     vasculogenesis GO:0001570 IEA     osteoblast differentiation GO:0001649 IEA     negative regulation of endothelial cell proliferation GO:0001937 IDA     positive regulation of endothelial cell proliferation GO:0001938 IDA     transcription by RNA polymerase II GO:0006366 IEA     intracellular iron ion homeostasis GO:0006879 TAS     negative regulation of DNA replication GO:0008156 TAS     negative regulation of endothelial cell migration GO:0010596 IDA     negative regulation of angiogenesis GO:0016525 TAS     negative regulation of cell growth GO:0030308 IDA     BMP signaling pathway GO:0030509 IBA     BMP signaling pathway GO:0030509 IDA     positive regulation of BMP signaling pathway GO:0030513 IEA     positive regulation of epithelial cell differentiation GO:0030858 IDA     positive regulation of interleukin-8 production GO:0032757 IDA     activin receptor signaling pathway GO:0032924 IDA     negative regulation of blood vessel endothelial cell migration GO:0043537 TAS     positive regulation of endothelial cell differentiation GO:0045603 IEA     positive regulation of Notch signaling pathway GO:0045747 IDA     positive regulation of angiogenesis GO:0045766 IDA     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     blood vessel morphogenesis GO:0048514 IDA     cartilage development GO:0051216 TAS     positive regulation of SMAD protein signal transduction GO:0060391 IDA     positive regulation of cartilage development GO:0061036 IEA     cellular response to BMP stimulus GO:0071773 IDA     positive regulation of bicellular tight junction assembly GO:1903348 IDA Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular exosome GO:0070062 HDA