Gene description for JAK2
Gene name Janus kinase 2
Gene symbol JAK2
Other names/aliases JTK10
THCYT3
Species Homo sapiens
 Database cross references - JAK2
ExoCarta ExoCarta_3717
Vesiclepedia VP_3717
Entrez Gene 3717
HGNC 6192
MIM 147796
UniProt O60674  
 JAK2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for JAK2
Molecular Function
    protein kinase activity GO:0004672 NAS
    protein tyrosine kinase activity GO:0004713 EXP
    protein tyrosine kinase activity GO:0004713 IDA
    protein tyrosine kinase activity GO:0004713 ISS
    protein tyrosine kinase activity GO:0004713 TAS
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 TAS
    signaling receptor binding GO:0005102 IPI
    growth hormone receptor binding GO:0005131 IBA
    growth hormone receptor binding GO:0005131 ISS
    interleukin-12 receptor binding GO:0005143 ISS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    protein kinase binding GO:0019901 IDA
    heme binding GO:0020037 IDA
    signaling receptor activator activity GO:0030546 ISS
    type 1 angiotensin receptor binding GO:0031702 IEA
    acetylcholine receptor binding GO:0033130 IEA
    histone H3Y41 kinase activity GO:0035401 IDA
    SH2 domain binding GO:0042169 IPI
    histone binding GO:0042393 IDA
    identical protein binding GO:0042802 IPI
    phosphatidylinositol 3-kinase binding GO:0043548 IEA
    insulin receptor substrate binding GO:0043560 IEA
    metal ion binding GO:0046872 IEA
    peptide hormone receptor binding GO:0051428 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    microglial cell activation GO:0001774 ISS
    adaptive immune response GO:0002250 IEA
    chromatin remodeling GO:0006338 IEA
    transcription by RNA polymerase II GO:0006366 IEA
    apoptotic process GO:0006915 ISS
    immune response GO:0006955 NAS
    cell adhesion GO:0007155 IDA
    signal transduction GO:0007165 ISS
    enzyme-linked receptor protein signaling pathway GO:0007167 ISS
    positive regulation of cytosolic calcium ion concentration GO:0007204 IEA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IBA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IDA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 ISS
    mesoderm development GO:0007498 TAS
    negative regulation of cell population proliferation GO:0008285 ISS
    intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 IEA
    positive regulation of platelet activation GO:0010572 IDA
    negative regulation of cardiac muscle cell apoptotic process GO:0010667 IEA
    positive regulation of cell-substrate adhesion GO:0010811 IDA
    response to amine GO:0014075 IEA
    cytokine-mediated signaling pathway GO:0019221 IBA
    cytokine-mediated signaling pathway GO:0019221 IDA
    cytokine-mediated signaling pathway GO:0019221 ISS
    cytokine-mediated signaling pathway GO:0019221 TAS
    negative regulation of cell-cell adhesion GO:0022408 IEA
    actin filament polymerization GO:0030041 NAS
    cell differentiation GO:0030154 ISS
    erythrocyte differentiation GO:0030218 IBA
    erythrocyte differentiation GO:0030218 ISS
    positive regulation of cell migration GO:0030335 IEA
    axon regeneration GO:0031103 IEA
    lipopolysaccharide-mediated signaling pathway GO:0031663 ISS
    nuclear receptor-mediated mineralocorticoid signaling pathway GO:0031959 IEA
    positive regulation of insulin secretion GO:0032024 IEA
    positive regulation of type II interferon production GO:0032729 IDA
    positive regulation of interleukin-1 beta production GO:0032731 ISS
    positive regulation of interleukin-17 production GO:0032740 NAS
    positive regulation of tumor necrosis factor production GO:0032760 ISS
    positive regulation of tumor necrosis factor production GO:0032760 ISS
    positive regulation of natural killer cell proliferation GO:0032819 IDA
    response to hydroperoxide GO:0033194 IEA
    tumor necrosis factor-mediated signaling pathway GO:0033209 IDA
    symbiont-induced defense-related programmed cell death GO:0034050 IEA
    response to tumor necrosis factor GO:0034612 IDA
    post-embryonic hemopoiesis GO:0035166 IEA
    intracellular signal transduction GO:0035556 IBA
    intracellular signal transduction GO:0035556 ISS
    interleukin-12-mediated signaling pathway GO:0035722 IDA
    cellular response to interleukin-3 GO:0036016 IEA
    interleukin-5-mediated signaling pathway GO:0038043 IDA
    collagen-activated signaling pathway GO:0038065 IMP
    interleukin-23-mediated signaling pathway GO:0038155 IDA
    interleukin-3-mediated signaling pathway GO:0038156 IDA
    granulocyte-macrophage colony-stimulating factor signaling pathway GO:0038157 IDA
    erythropoietin-mediated signaling pathway GO:0038162 IDA
    thrombopoietin-mediated signaling pathway GO:0038163 IDA
    positive regulation of T cell proliferation GO:0042102 IDA
    positive regulation of protein import into nucleus GO:0042307 IEA
    positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 ISS
    activation of Janus kinase activity GO:0042976 ISS
    regulation of apoptotic process GO:0042981 IBA
    positive regulation of MAPK cascade GO:0043410 IEA
    negative regulation of neuron apoptotic process GO:0043524 IEA
    post-translational protein modification GO:0043687 IDA
    positive regulation of MHC class II biosynthetic process GO:0045348 ISS
    regulation of nitric oxide biosynthetic process GO:0045428 ISS
    positive regulation of nitric oxide biosynthetic process GO:0045429 IEA
    positive regulation of cell differentiation GO:0045597 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    regulation of receptor signaling pathway via JAK-STAT GO:0046425 ISS
    positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 IDA
    response to antibiotic GO:0046677 IDA
    protein autophosphorylation GO:0046777 ISS
    platelet-derived growth factor receptor signaling pathway GO:0048008 IEA
    regulation of inflammatory response GO:0050727 IDA
    modulation of chemical synaptic transmission GO:0050804 IEA
    positive regulation of NK T cell proliferation GO:0051142 IDA
    positive regulation of NK T cell proliferation GO:0051142 NAS
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 TAS
    type II interferon-mediated signaling pathway GO:0060333 NAS
    type II interferon-mediated signaling pathway GO:0060333 TAS
    positive regulation of SMAD protein signal transduction GO:0060391 IGI
    growth hormone receptor signaling pathway GO:0060396 IDA
    growth hormone receptor signaling pathway via JAK-STAT GO:0060397 IBA
    growth hormone receptor signaling pathway via JAK-STAT GO:0060397 IDA
    growth hormone receptor signaling pathway via JAK-STAT GO:0060397 ISS
    positive regulation of growth hormone receptor signaling pathway GO:0060399 ISS
    mammary gland epithelium development GO:0061180 ISS
    interleukin-6-mediated signaling pathway GO:0070102 TAS
    positive regulation of leukocyte proliferation GO:0070665 IDA
    response to interleukin-12 GO:0070671 IDA
    interleukin-35-mediated signaling pathway GO:0070757 TAS
    cellular response to dexamethasone stimulus GO:0071549 IEA
    extrinsic apoptotic signaling pathway GO:0097191 ISS
    cellular response to virus GO:0098586 NAS
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
    positive regulation of platelet aggregation GO:1901731 IDA
    positive regulation of growth factor dependent skeletal muscle satellite cell proliferation GO:1902728 IEA
    positive regulation of epithelial cell apoptotic process GO:1904037 IEA
    positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 IEA
    regulation of postsynapse to nucleus signaling pathway GO:1905539 IEA
    positive regulation of T-helper 17 type immune response GO:2000318 NAS
    positive regulation of apoptotic signaling pathway GO:2001235 IEA
Subcellular Localization
    euchromatin GO:0000791 IEA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 NAS
    caveola GO:0005901 ISS
    focal adhesion GO:0005925 IDA
    cytoplasmic side of plasma membrane GO:0009898 IDA
    extrinsic component of plasma membrane GO:0019897 IDA
    granulocyte macrophage colony-stimulating factor receptor complex GO:0030526 IDA
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IC
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IDA
    endosome lumen GO:0031904 TAS
    interleukin-12 receptor complex GO:0042022 NAS
    membrane raft GO:0045121 ISS
    interleukin-23 receptor complex GO:0072536 NAS
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified JAK2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for JAK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SPRR3 6707
Affinity Capture-MS Homo sapiens
2 SHC1 6464
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
3 STAT5B 6777
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
4 STAT5A 6776
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
5 KPNB1 3837
Affinity Capture-MS Homo sapiens
6 PBK  
Affinity Capture-MS Homo sapiens
7 BRCA1 672
Affinity Capture-Western Homo sapiens
8 SLC2A1 6513
Affinity Capture-MS Homo sapiens
9 SOCS1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Protein-peptide Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
10 HSP90AB1 3326
Affinity Capture-Western Homo sapiens
11 PPIA 5478
Affinity Capture-Western Homo sapiens
12 VHL  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 IFNGR1 3459
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
14 PTPN1 5770
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
15 HMMR  
Affinity Capture-MS Homo sapiens
16 PPP1CC 5501
Two-hybrid Homo sapiens
17 IGHA2 3494
Affinity Capture-MS Homo sapiens
18 MAP3K5 4217
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
19 IL6ST 3572
Affinity Capture-Western Homo sapiens
20 PPP2R1B 5519
Affinity Capture-Western Homo sapiens
21 CTLA4  
Affinity Capture-Western Homo sapiens
22 PTPN12 5782
Affinity Capture-Western Homo sapiens
23 ERBB3 2065
Protein-peptide Homo sapiens
24 RCN1 5954
Affinity Capture-MS Homo sapiens
25 STAT3 6774
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
26 AGTR1  
Affinity Capture-Western Homo sapiens
27 ALK 238
Affinity Capture-MS Homo sapiens
28 USP33  
Affinity Capture-Western Homo sapiens
29 EPOR  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
30 JCHAIN 3512
Affinity Capture-MS Homo sapiens
31 SOCS3 9021
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
32 ERBB2 2064
Affinity Capture-Western Homo sapiens
33 FGFR1 2260
Affinity Capture-Western Homo sapiens
34 HSPA8 3312
Affinity Capture-Western Homo sapiens
35 GTF2I 2969
Biochemical Activity Homo sapiens
36 CST2  
Affinity Capture-MS Homo sapiens
37 TSHR 7253
Affinity Capture-Western Homo sapiens
38 PTPN6 5777
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
39 STAM2 10254
Affinity Capture-Western Homo sapiens
40 KIT 3815
Affinity Capture-Western Homo sapiens
41 VAV1 7409
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
42 EMD 2010
Affinity Capture-MS Homo sapiens
43 TUB  
Biochemical Activity Homo sapiens
44 OPTN 10133
Affinity Capture-Western Homo sapiens
45 LYN 4067
Reconstituted Complex Homo sapiens
46 BACH1 571
Affinity Capture-MS Homo sapiens
47 TEC 7006
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
48 CSF2RB  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
49 SH2B2  
Biochemical Activity Homo sapiens
50 UBP1 7342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 FYN 2534
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
52 MUC5B  
Affinity Capture-MS Homo sapiens
53 CCR5 1234
Affinity Capture-Western Homo sapiens
54 PTK2B 2185
Affinity Capture-Western Homo sapiens
55 PRLR  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
56 PIK3R1 5295
Reconstituted Complex Homo sapiens
Negative Genetic Homo sapiens
57 STAM 8027
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
58 PTPN11 5781
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
59 CXCR4 7852
Affinity Capture-Western Homo sapiens
60 SKP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
61 MUC7 4589
Affinity Capture-MS Homo sapiens
62 HIST2H3C 126961
Affinity Capture-Western Homo sapiens
63 ZG16B 124220
Affinity Capture-MS Homo sapiens
64 SIRPA 140885
Affinity Capture-Western Homo sapiens
65 TNFRSF1A 7132
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
66 TRAF6 7189
Two-hybrid Homo sapiens
67 ASS1 445
Two-hybrid Homo sapiens
68 EGFR 1956
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
69 PTK2 5747
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
70 NAP1L1 4673
Affinity Capture-MS Homo sapiens
71 IL5RA  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
72 ELP2 55250
Affinity Capture-Western Homo sapiens
73 HIST3H3 8290
Biochemical Activity Homo sapiens
74 GRB10 2887
Affinity Capture-Western Homo sapiens
75 AMY1C 278
Affinity Capture-MS Homo sapiens
76 PRMT5 10419
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
77 STAT1 6772
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
78 SH2B1 25970
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
79 RAF1 5894
Reconstituted Complex Homo sapiens
80 IL2RB  
Affinity Capture-Western Homo sapiens
81 IL12RB2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
82 CDKN1B 1027
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
83 PTAFR  
Affinity Capture-Western Homo sapiens
84 IFNGR2  
Reconstituted Complex Homo sapiens
85 DTX3L 151636
Affinity Capture-Western Homo sapiens
86 GRB2 2885
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
87 IL2RG  
Affinity Capture-Western Homo sapiens
88 IKBKG 8517
Reconstituted Complex Homo sapiens
89 DNAJA3 9093
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
90 INSR 3643
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
91 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
92 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
93 RBMX 27316
Two-hybrid Homo sapiens
94 BPIFA2 140683
Affinity Capture-MS Homo sapiens
95 HTR2A  
Affinity Capture-Western Homo sapiens
96 IL4R  
Affinity Capture-Western Homo sapiens
97 EZH2  
Biochemical Activity Homo sapiens
98 JOSD1  
Affinity Capture-Western Homo sapiens
99 CISH  
Protein-peptide Homo sapiens
100 GHR  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
101 JAK2 3717
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
102 IRS1 3667
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
103 ASB2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which JAK2 is involved
PathwayEvidenceSource
Cell Cycle TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin organization TAS Reactome
Cyclin D associated events in G1 TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) TAS Reactome
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) IEA Reactome
Erythropoietin activates Phospholipase C gamma (PLCG) IEA Reactome
Erythropoietin activates RAS IEA Reactome
Erythropoietin activates RAS TAS Reactome
Erythropoietin activates STAT5 IEA Reactome
Factors involved in megakaryocyte development and platelet production TAS Reactome
G1 Phase TAS Reactome
Growth hormone receptor signaling TAS Reactome
Growth hormone receptor signaling IEA Reactome
Hemostasis TAS Reactome
IFNG signaling activates MAPKs TAS Reactome
IL-6-type cytokine receptor ligand interactions TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Inactivation of CSF3 (G-CSF) signaling IEA Reactome
Inactivation of CSF3 (G-CSF) signaling TAS Reactome
Infectious disease TAS Reactome
Interferon gamma signaling TAS Reactome
Interferon gamma signaling IEA Reactome
Interferon Signaling TAS Reactome
Interferon Signaling IEA Reactome
Interleukin receptor SHC signaling TAS Reactome
Interleukin-12 family signaling IEA Reactome
Interleukin-12 family signaling TAS Reactome
Interleukin-12 signaling IEA Reactome
Interleukin-12 signaling TAS Reactome
Interleukin-2 family signaling TAS Reactome
Interleukin-20 family signaling TAS Reactome
Interleukin-23 signaling IEA Reactome
Interleukin-23 signaling TAS Reactome
Interleukin-27 signaling IEA Reactome
Interleukin-27 signaling TAS Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling IEA Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling TAS Reactome
Interleukin-35 Signalling TAS Reactome
Interleukin-4 and Interleukin-13 signaling TAS Reactome
Interleukin-6 family signaling TAS Reactome
Interleukin-6 family signaling IEA Reactome
Interleukin-6 signaling TAS Reactome
Interleukin-6 signaling IEA Reactome
MAPK family signaling cascades TAS Reactome
MAPK1 (ERK2) activation TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
MAPK3 (ERK1) activation TAS Reactome
Mitotic G1 phase and G1/S transition TAS Reactome
Oncogenic MAPK signaling TAS Reactome
Paradoxical activation of RAF signaling by kinase inactive BRAF TAS Reactome
Potential therapeutics for SARS TAS Reactome
Prolactin receptor signaling IEA Reactome
Prolactin receptor signaling TAS Reactome
RAF activation TAS Reactome
RAF-independent MAPK1/3 activation TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Regulation of IFNG signaling IEA Reactome
Regulation of IFNG signaling TAS Reactome
RMTs methylate histone arginines TAS Reactome
SARS-CoV Infections TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by BRAF and RAF1 fusions TAS Reactome
Signaling by CSF3 (G-CSF) IEA Reactome
Signaling by CSF3 (G-CSF) TAS Reactome
Signaling by Erythropoietin IEA Reactome
Signaling by Erythropoietin TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by Interleukins IEA Reactome
Signaling by KIT in disease TAS Reactome
Signaling by Leptin IEA Reactome
Signaling by moderate kinase activity BRAF mutants TAS Reactome
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants TAS Reactome
Signaling by RAF1 mutants TAS Reactome
Signaling by RAS mutants TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by SCF-KIT TAS Reactome
Signaling downstream of RAS mutants TAS Reactome
Viral Infection Pathways TAS Reactome





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