Gene description for SOCS3
Gene name	suppressor of cytokine signaling 3
Gene symbol	SOCS3
Other names/aliases	ATOD4 CIS3 Cish3 SOCS-3 SSI-3 SSI3
Species	Homo sapiens
Database cross references - SOCS3
ExoCarta	ExoCarta_9021
Vesiclepedia	VP_9021
Entrez Gene	9021
HGNC	19391
MIM	604176
UniProt	O14543
SOCS3 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Hepatocytes	26054723

Gene ontology annotations for SOCS3

Molecular Function     phosphotyrosine residue binding GO:0001784 IEA     protein kinase inhibitor activity GO:0004860 TAS     cytokine receptor binding GO:0005126 IBA     protein binding GO:0005515 IPI     protein tyrosine kinase inhibitor activity GO:0030292 IDA     miRNA binding GO:0035198 IEA Biological Process     protein ubiquitination GO:0016567 IEA     cytokine-mediated signaling pathway GO:0019221 IBA     intracellular signal transduction GO:0035556 IEA     negative regulation of apoptotic process GO:0043066 TAS     positive regulation of cell differentiation GO:0045597 IEA     negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 IBA     negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 IMP     negative regulation of insulin receptor signaling pathway GO:0046627 IEA     negative regulation of inflammatory response GO:0050728 IEA     branching involved in labyrinthine layer morphogenesis GO:0060670 IEA     placenta blood vessel development GO:0060674 IEA     T-helper 17 cell lineage commitment GO:0072540 TAS     cellular response to interleukin-17 GO:0097398 IEA     cellular response to leukemia inhibitory factor GO:1990830 IEA Subcellular Localization     cytosol GO:0005829 TAS     cytosol GO:0005829 TAS     cytoplasmic side of plasma membrane GO:0009898 IDA