Gene description for JAK1
Gene name Janus kinase 1
Gene symbol JAK1
Other names/aliases JAK1A
JAK1B
JTK3
Species Homo sapiens
 Database cross references - JAK1
ExoCarta ExoCarta_3716
Vesiclepedia VP_3716
Entrez Gene 3716
HGNC 6190
MIM 147795
UniProt P23458  
 JAK1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 34887515    
Endothelial cells 26027894    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
Melanoma cells 22635005    
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for JAK1
Molecular Function
    protein tyrosine kinase activity GO:0004713 EXP
    protein tyrosine kinase activity GO:0004713 IC
    protein tyrosine kinase activity GO:0004713 IDA
    protein tyrosine kinase activity GO:0004713 TAS
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 TAS
    growth hormone receptor binding GO:0005131 IBA
    growth hormone receptor binding GO:0005131 ISS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    protein phosphatase binding GO:0019903 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
    CCR5 chemokine receptor binding GO:0031730 IEA
    histone H3Y41 kinase activity GO:0035401 IEA
    metal ion binding GO:0046872 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IMP
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IBA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IDA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IMP
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 NAS
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 TAS
    cytokine-mediated signaling pathway GO:0019221 IBA
    cytokine-mediated signaling pathway GO:0019221 TAS
    cell differentiation GO:0030154 IBA
    positive regulation of homotypic cell-cell adhesion GO:0034112 IMP
    intracellular signal transduction GO:0035556 IBA
    interleukin-15-mediated signaling pathway GO:0035723 IDA
    interleukin-4-mediated signaling pathway GO:0035771 IDA
    interleukin-4-mediated signaling pathway GO:0035771 NAS
    interleukin-2-mediated signaling pathway GO:0038110 IDA
    interleukin-2-mediated signaling pathway GO:0038110 TAS
    interleukin-7-mediated signaling pathway GO:0038111 IC
    interleukin-9-mediated signaling pathway GO:0038113 IDA
    interleukin-11-mediated signaling pathway GO:0038154 IDA
    type III interferon-mediated signaling pathway GO:0038196 NAS
    response to antibiotic GO:0046677 IDA
    type II interferon-mediated signaling pathway GO:0060333 IDA
    type II interferon-mediated signaling pathway GO:0060333 NAS
    type II interferon-mediated signaling pathway GO:0060333 TAS
    type I interferon-mediated signaling pathway GO:0060337 IDA
    type I interferon-mediated signaling pathway GO:0060337 NAS
    type I interferon-mediated signaling pathway GO:0060337 TAS
    growth hormone receptor signaling pathway via JAK-STAT GO:0060397 IBA
    interleukin-6-mediated signaling pathway GO:0070102 IDA
    interleukin-6-mediated signaling pathway GO:0070102 TAS
    T-helper 17 cell lineage commitment GO:0072540 TAS
    cellular response to virus GO:0098586 NAS
    interleukin-10-mediated signaling pathway GO:0140105 IDA
    protein localization to cell-cell junction GO:0150105 IMP
    positive regulation of protein localization to nucleus GO:1900182 IDA
    positive regulation of sprouting angiogenesis GO:1903672 IGI
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IC
    cytoplasm GO:0005737 IDA
    endosome GO:0005768 TAS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IC
    plasma membrane GO:0005886 TAS
    focal adhesion GO:0005925 HDA
    cytoplasmic side of plasma membrane GO:0009898 IDA
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IC
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IDA
 Experiment description of studies that identified JAK1 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 1203
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
6
Experiment ID 226
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
7
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 236
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
11
Experiment ID 237
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
12
Experiment ID 200
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22635005    
Organism Homo sapiens
Experiment description Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Authors "Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, Garcia-Santos G, Ghajar C, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D."
Journal name Nat Med
Publication year 2012
Sample Melanoma cells
Sample name B16-F10
SK-MEL-202
SK-MEL035
SK-MEL-265
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
14
Experiment ID 224
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
15
Experiment ID 211
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 212
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 217
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for JAK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 ADAM11 4185
Affinity Capture-MS Homo sapiens
4 LRRIQ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ISG15 9636
Affinity Capture-MS Homo sapiens
6 ABL2  
Affinity Capture-Western Homo sapiens
7 Sgol2  
Affinity Capture-MS Mus musculus
8 UBL4A 8266
Affinity Capture-MS Homo sapiens
9 STAT5B 6777
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
10 LAMP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 STAT5A 6776
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
12 HCST  
Affinity Capture-MS Homo sapiens
13 LPAR6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 YWHAE 7531
Affinity Capture-MS Homo sapiens
15 TRIM66  
Affinity Capture-MS Homo sapiens
16 BRCA1 672
Affinity Capture-Western Homo sapiens
17 SHB 6461
Reconstituted Complex Homo sapiens
18 LAMP2 3920
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 GPR182  
Affinity Capture-MS Homo sapiens
20 IFNGR1 3459
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 SYVN1 84447
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
22 FFAR1  
Affinity Capture-MS Homo sapiens
23 IL21R  
Affinity Capture-Western Homo sapiens
24 AMHR2  
Affinity Capture-MS Homo sapiens
25 KIAA1429 25962
Affinity Capture-MS Homo sapiens
26 SLC18A2  
Affinity Capture-MS Homo sapiens
27 IL6ST 3572
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
28 BTN2A1 11120
Affinity Capture-MS Homo sapiens
29 INSRR 3645
Affinity Capture-MS Homo sapiens
30 CTDSPL2  
Affinity Capture-MS Homo sapiens
31 FAM174A 345757
Affinity Capture-MS Homo sapiens
32 FBXW7  
Affinity Capture-MS Homo sapiens
33 SNX27 81609
Affinity Capture-MS Homo sapiens
34 UFL1 23376
Affinity Capture-MS Homo sapiens
35 GPRC5B 51704
Affinity Capture-MS Homo sapiens
36 STAT3 6774
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
37 AGTR1  
Two-hybrid Homo sapiens
38 ELF3 1999
Affinity Capture-MS Homo sapiens
39 TMEM192 201931
Affinity Capture-MS Homo sapiens
40 EDAR  
Affinity Capture-MS Homo sapiens
41 MARCH1  
Affinity Capture-MS Homo sapiens
42 SOCS3 9021
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
43 KIF15 56992
Affinity Capture-MS Homo sapiens
44 IL13RA2 3598
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 ERBB2 2064
Protein-peptide Homo sapiens
46 STAT6 6778
Biochemical Activity Homo sapiens
47 MAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CLDND1 56650
Affinity Capture-MS Homo sapiens
49 TNF  
Positive Genetic Homo sapiens
50 VSIG4  
Affinity Capture-MS Homo sapiens
51 TSHR 7253
Affinity Capture-Western Homo sapiens
52 PLA2G4A 5321
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
53 EIF2AK2 5610
Affinity Capture-Western Homo sapiens
54 PLAUR 5329
Affinity Capture-Western Homo sapiens
55 MANSC1 54682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 CX3CL1  
Affinity Capture-MS Homo sapiens
57 KCNC3 3748
Affinity Capture-MS Homo sapiens
58 IGF1R 3480
Reconstituted Complex Homo sapiens
59 MCAM 4162
Proximity Label-MS Homo sapiens
60 Arrb2  
Affinity Capture-MS Mus musculus
61 ATF2  
Negative Genetic Homo sapiens
62 IL20RB  
Affinity Capture-MS Homo sapiens
63 CSF2RB  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
64 CHMP4B 128866
Affinity Capture-MS Homo sapiens
65 CSNK1G2 1455
Affinity Capture-MS Homo sapiens
66 TYK2 7297
Affinity Capture-Western Homo sapiens
67 TRIM21 6737
Affinity Capture-MS Homo sapiens
68 NTRK1 4914
Affinity Capture-MS Homo sapiens
69 IFI16 3428
Affinity Capture-MS Homo sapiens
70 PTK2B 2185
Affinity Capture-Western Homo sapiens
71 IL10RA  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
72 IL27RA 9466
Affinity Capture-Western Homo sapiens
73 S100B 6285
Affinity Capture-MS Homo sapiens
74 E2F1 1869
Negative Genetic Homo sapiens
75 ARL15 54622
Affinity Capture-MS Homo sapiens
76 PML 5371
Affinity Capture-Western Homo sapiens
Positive Genetic Homo sapiens
77 OSMR 9180
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 Bmpr1a  
Affinity Capture-MS Mus musculus
79 MAGOH 4116
Affinity Capture-MS Homo sapiens
80 RNF125  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
81 MRAP2  
Affinity Capture-MS Homo sapiens
82 ELOVL5 60481
Proximity Label-MS Homo sapiens
83 CMKLR1 1240
Affinity Capture-MS Homo sapiens
84 HSPB8 26353
Affinity Capture-MS Homo sapiens
85 CYLD  
Affinity Capture-MS Homo sapiens
86 TIRAP  
Affinity Capture-MS Homo sapiens
87 IL9R  
Affinity Capture-Western Homo sapiens
88 SYT11 23208
Affinity Capture-MS Homo sapiens
89 TICAM2  
Affinity Capture-MS Homo sapiens
90 PCDHA8  
Affinity Capture-MS Homo sapiens
91 PRKCZ 5590
Affinity Capture-MS Homo sapiens
92 PTPN11 5781
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
93 SLC15A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 SOCS2  
Protein-peptide Homo sapiens
95 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 CXCR4 7852
Affinity Capture-MS Homo sapiens
97 MGARP  
Affinity Capture-MS Homo sapiens
98 PTPN6 5777
Biochemical Activity Homo sapiens
99 ARRDC4  
Affinity Capture-MS Homo sapiens
100 CD83  
Affinity Capture-MS Homo sapiens
101 HIST3H3 8290
Biochemical Activity Homo sapiens
102 SMAD3 4088
Positive Genetic Homo sapiens
103 PTH2R  
Affinity Capture-MS Homo sapiens
104 SOCS1  
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
105 MEX3A  
Affinity Capture-RNA Homo sapiens
106 GHR  
Affinity Capture-Western Homo sapiens
107 TNFRSF1A 7132
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
108 CLEC4A  
Affinity Capture-MS Homo sapiens
109 EGFR 1956
Affinity Capture-MS Homo sapiens
110 CISH  
Protein-peptide Homo sapiens
111 IL5RA  
Affinity Capture-Western Homo sapiens
112 ELP2 55250
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
113 TAGLN 6876
Affinity Capture-Western Homo sapiens
114 GAB1  
Reconstituted Complex Homo sapiens
115 PRMT5 10419
Reconstituted Complex Homo sapiens
116 KCNE3  
Affinity Capture-MS Homo sapiens
117 AGO4  
Affinity Capture-MS Homo sapiens
118 STAT1 6772
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
119 CSF3R  
Affinity Capture-Western Homo sapiens
120 IFNAR1  
Affinity Capture-MS Homo sapiens
121 JAK1 3716
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
122 USP16  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
123 RELT  
Affinity Capture-MS Homo sapiens
124 GPR45  
Affinity Capture-MS Homo sapiens
125 TOP1 7150
Protein-peptide Homo sapiens
126 FAM46A  
Affinity Capture-MS Homo sapiens
127 NFKB1 4790
Positive Genetic Homo sapiens
128 RAF1 5894
Affinity Capture-Western Homo sapiens
129 IL2RB  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
130 P2RY10  
Affinity Capture-MS Homo sapiens
131 TEC 7006
Affinity Capture-Western Homo sapiens
132 GNB2L1 10399
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
133 MDM2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
134 TGFBR2 7048
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 ATIC 471
Affinity Capture-MS Homo sapiens
136 DSP 1832
Affinity Capture-MS Homo sapiens
137 STUB1 10273
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
138 ZRANB1 54764
Affinity Capture-MS Homo sapiens
139 BTK 695
Affinity Capture-Western Homo sapiens
140 CRLF2 64109
Affinity Capture-MS Homo sapiens
141 KIF24  
Affinity Capture-MS Homo sapiens
142 TMEM9 252839
Affinity Capture-MS Homo sapiens
143 DTX3L 151636
Affinity Capture-Western Homo sapiens
144 GRB2 2885
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
145 TP53 7157
Affinity Capture-MS Homo sapiens
146 OPALIN  
Affinity Capture-MS Homo sapiens
147 MFSD4  
Affinity Capture-MS Homo sapiens
148 OSTM1 28962
Affinity Capture-MS Homo sapiens
149 Tsc1  
Affinity Capture-MS Mus musculus
150 IL2RG  
Affinity Capture-Western Homo sapiens
151 HAVCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 IRS2 8660
Affinity Capture-Western Homo sapiens
153 SMURF1 57154
Affinity Capture-MS Homo sapiens
154 EFNB1 1947
Affinity Capture-MS Homo sapiens
155 ABL1 25
Reconstituted Complex Homo sapiens
156 INSR 3643
Affinity Capture-Western Homo sapiens
157 PRMT1 3276
Affinity Capture-MS Homo sapiens
158 Shoc2  
Affinity Capture-MS Mus musculus
159 DLK1  
Affinity Capture-MS Homo sapiens
160 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
161 EIF4A3 9775
Affinity Capture-MS Homo sapiens
162 SIRT1  
Affinity Capture-Western Homo sapiens
163 IFNLR1  
Affinity Capture-MS Homo sapiens
164 ESR1  
Affinity Capture-MS Homo sapiens
165 IL4R  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 NOC2L 26155
Affinity Capture-Western Homo sapiens
167 IFNAR2 3455
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
168 BSND  
Affinity Capture-MS Homo sapiens
169 ARRB1 408
Affinity Capture-MS Homo sapiens
170 STAM2 10254
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
171 EID1  
Affinity Capture-MS Homo sapiens
172 IL6 3569
Positive Genetic Homo sapiens
173 CFTR 1080
Affinity Capture-Western Homo sapiens
174 SLC1A1 6505
Affinity Capture-MS Homo sapiens
175 MEN1 4221
Affinity Capture-MS Homo sapiens
176 IRS1 3667
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
177 PDCD1  
Affinity Capture-MS Homo sapiens
178 FLG2 388698
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which JAK1 is involved
PathwayEvidenceSource
Antiviral mechanism by IFN-stimulated genes TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
Disease TAS Reactome
Evasion by RSV of host interferon responses TAS Reactome
IFNG signaling activates MAPKs TAS Reactome
IL-6-type cytokine receptor ligand interactions TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Inactivation of CSF3 (G-CSF) signaling IEA Reactome
Inactivation of CSF3 (G-CSF) signaling TAS Reactome
Infectious disease TAS Reactome
Interferon alpha/beta signaling TAS Reactome
Interferon alpha/beta signaling IEA Reactome
Interferon gamma signaling TAS Reactome
Interferon gamma signaling IEA Reactome
Interferon Signaling TAS Reactome
Interferon Signaling IEA Reactome
Interleukin receptor SHC signaling TAS Reactome
Interleukin-10 signaling TAS Reactome
Interleukin-12 family signaling IEA Reactome
Interleukin-12 family signaling TAS Reactome
Interleukin-12 signaling TAS Reactome
Interleukin-12 signaling IEA Reactome
Interleukin-15 signaling TAS Reactome
Interleukin-15 signaling IEA Reactome
Interleukin-2 family signaling TAS Reactome
Interleukin-2 family signaling IEA Reactome
Interleukin-2 signaling TAS Reactome
Interleukin-20 family signaling TAS Reactome
Interleukin-21 signaling TAS Reactome
Interleukin-27 signaling IEA Reactome
Interleukin-27 signaling TAS Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling TAS Reactome
Interleukin-35 Signalling TAS Reactome
Interleukin-4 and Interleukin-13 signaling TAS Reactome
Interleukin-6 family signaling TAS Reactome
Interleukin-6 family signaling IEA Reactome
Interleukin-6 signaling TAS Reactome
Interleukin-6 signaling IEA Reactome
Interleukin-7 signaling TAS Reactome
Interleukin-7 signaling IEA Reactome
Interleukin-9 signaling TAS Reactome
ISG15 antiviral mechanism TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1 (ERK2) activation TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
MAPK3 (ERK1) activation TAS Reactome
Other interleukin signaling TAS Reactome
Potential therapeutics for SARS TAS Reactome
RAF-independent MAPK1/3 activation TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Regulation of IFNA/IFNB signaling TAS Reactome
Regulation of IFNA/IFNB signaling IEA Reactome
Regulation of IFNG signaling IEA Reactome
Regulation of IFNG signaling TAS Reactome
Respiratory Syncytial Virus Infection Pathway TAS Reactome
RSV-host interactions TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-2 activates/modulates innate and adaptive immune responses TAS Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2-host interactions TAS Reactome
Signal Transduction TAS Reactome
Signaling by CSF3 (G-CSF) IEA Reactome
Signaling by CSF3 (G-CSF) TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by Interleukins IEA Reactome
Viral Infection Pathways TAS Reactome





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