Gene description for HIST3H3
Gene name histone cluster 3, H3
Gene symbol HIST3H3
Other names/aliases H3.4
H3/g
H3FT
H3t
Species Homo sapiens
 Database cross references - HIST3H3
ExoCarta ExoCarta_8290
Vesiclepedia VP_8290
Entrez Gene 8290
HGNC 4778
MIM 602820
UniProt Q16695  
 HIST3H3 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for HIST3H3
Molecular Function
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
    structural constituent of chromatin GO:0030527 IEA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    chromatin organization GO:0006325 NAS
    nucleosome assembly GO:0006334 IDA
    nucleosome assembly GO:0006334 IMP
Subcellular Localization
    chromosome, telomeric region GO:0000781 HDA
    nucleosome GO:0000786 IDA
    nucleosome GO:0000786 IPI
    nucleus GO:0005634 HDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified HIST3H3 in sEVs
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 138
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
3
Experiment ID 143
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
4
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
5
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 196
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 197
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HIST3H3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
3 TADA1  
Protein-peptide Homo sapiens
4 CHAF1A  
Protein-peptide Homo sapiens
5 MCM7 4176
Affinity Capture-MS Homo sapiens
6 LUZP4  
Affinity Capture-MS Homo sapiens
7 CBX1 10951
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Protein-peptide Homo sapiens
8 KMT2C 58508
Biochemical Activity Homo sapiens
9 HDAC2 3066
Biochemical Activity Homo sapiens
10 ORC4  
Protein-peptide Homo sapiens
11 ANP32A 8125
Reconstituted Complex Homo sapiens
12 JADE3  
Protein-peptide Homo sapiens
13 CTBP2 1488
Biochemical Activity Homo sapiens
14 TAF4B  
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
15 HIST1H1D 3007
Cross-Linking-MS (XL-MS) Homo sapiens
16 BTF3 689
Affinity Capture-MS Homo sapiens
17 VPRBP 9730
Biochemical Activity Homo sapiens
18 NFATC1 4772
Affinity Capture-MS Homo sapiens
19 COPRS  
Reconstituted Complex Homo sapiens
20 SMNDC1  
Protein-peptide Homo sapiens
21 PHF12  
Protein-peptide Homo sapiens
22 TAF3 83860
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
23 TDRD3  
Protein-peptide Homo sapiens
24 ORC2  
Protein-peptide Homo sapiens
25 UBC 7316
Cross-Linking-MS (XL-MS) Homo sapiens
26 KDM6A  
Biochemical Activity Homo sapiens
27 HNRNPR 10236
Protein-peptide Homo sapiens
28 AFF1  
Biochemical Activity Homo sapiens
29 RREB1 6239
Biochemical Activity Homo sapiens
30 TAF1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
31 Ezh2  
Biochemical Activity Mus musculus
32 H2AFV 94239
Cross-Linking-MS (XL-MS) Homo sapiens
33 SFPQ 6421
Protein-peptide Homo sapiens
34 CREBBP  
Biochemical Activity Homo sapiens
35 HIST2H2AA3 8337
Cross-Linking-MS (XL-MS) Homo sapiens
36 MEF2A  
Affinity Capture-MS Homo sapiens
37 TRIM28 10155
Affinity Capture-Western Homo sapiens
38 TAF9 6880
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
39 C11orf30  
Protein-peptide Homo sapiens
40 HIST3H2A 92815
Affinity Capture-Luminescence Homo sapiens
41 MCM2 4171
Affinity Capture-MS Homo sapiens
42 TAF2  
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
43 PHC3  
Protein-peptide Homo sapiens
44 KDM2A  
Biochemical Activity Homo sapiens
45 HIST2H3A 333932
Cross-Linking-MS (XL-MS) Homo sapiens
46 SMYD3 64754
Biochemical Activity Homo sapiens
47 ERAP1 51752
Protein-peptide Homo sapiens
48 NPM1 4869
Far Western Homo sapiens
49 ZMYND11 10771
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
50 C4orf27  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
51 NCOA3  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
52 SIN3B  
Protein-peptide Homo sapiens
53 HIST4H4 121504
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
54 CBX7  
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
55 BMI1  
Protein-peptide Homo sapiens
56 RBP5 83758
Reconstituted Complex Homo sapiens
57 SYNE3 161176
Cross-Linking-MS (XL-MS) Homo sapiens
58 ITGA4 3676
Affinity Capture-MS Homo sapiens
59 EED  
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
60 NASP 4678
Two-hybrid Homo sapiens
61 ASH2L 9070
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
62 PHF7  
Protein-peptide Homo sapiens
63 NAP1L4 4676
Reconstituted Complex Homo sapiens
64 NSD1  
Biochemical Activity Homo sapiens
65 PHF1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
66 RAD50 10111
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
67 WDR5 11091
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
68 MRE11A 4361
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
69 MTA2 9219
Protein-peptide Homo sapiens
70 MSL3  
Protein-peptide Homo sapiens
71 HSPA8 3312
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
72 CHD1 1105
Protein-peptide Homo sapiens
73 ZNF217 7764
Biochemical Activity Homo sapiens
74 AURKA 6790
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
75 HSP90AB4P 664618
Cross-Linking-MS (XL-MS) Homo sapiens
76 TAF8  
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
77 RBBP7 5931
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
78 ING4  
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
79 HIST1H4A 8359
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
80 IRAK1  
Biochemical Activity Homo sapiens
81 KAT6B  
Affinity Capture-Western Homo sapiens
82 TADA3  
Protein-peptide Homo sapiens
83 TGM2 7052
Affinity Capture-Western Homo sapiens
84 WHSC1 7468
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
85 CTBP1 1487
Biochemical Activity Homo sapiens
86 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
87 C17orf49 124944
Protein-peptide Homo sapiens
88 ZNF746  
Affinity Capture-MS Homo sapiens
89 DOT1L 84444
Biochemical Activity Homo sapiens
90 NONO 4841
Protein-peptide Homo sapiens
91 NBN 4683
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
92 TAF11  
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
93 LRIF1  
Protein-peptide Homo sapiens
94 CBX3 11335
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
Protein-peptide Homo sapiens
95 ATAD2 29028
Reconstituted Complex Homo sapiens
96 TAF9B  
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
97 PRDM2  
Co-crystal Structure Homo sapiens
98 TAF10 6881
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
99 RAG1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
Biochemical Activity Homo sapiens
100 DEK 7913
Protein-peptide Homo sapiens
101 TAF4 6874
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
102 POGZ 23126
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
103 CDYL2  
Protein-peptide Homo sapiens
104 DPF2  
Protein-peptide Homo sapiens
105 PSMC5 5705
Affinity Capture-Western Homo sapiens
106 JADE2 23338
Protein-peptide Homo sapiens
107 CBX5 23468
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
108 TRPM7 54822
Biochemical Activity Homo sapiens
109 HIST1H1E 3008
Cross-Linking-MS (XL-MS) Homo sapiens
110 BPTF 2186
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
111 CBX6  
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
112 HIST2H2AC 8338
Cross-Linking-MS (XL-MS) Homo sapiens
113 HIST1H1C 3006
Cross-Linking-MS (XL-MS) Homo sapiens
114 KPNB1 3837
Cross-Linking-MS (XL-MS) Homo sapiens
115 CCDC101  
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
116 CHD5 26038
Affinity Capture-Western Homo sapiens
117 RPL36 25873
Cross-Linking-MS (XL-MS) Homo sapiens
118 WHSC1L1  
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
119 Kdm4c  
Biochemical Activity Mus musculus
120 MAGOH 4116
Affinity Capture-MS Homo sapiens
121 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
122 L3MBTL2  
Affinity Capture-Western Homo sapiens
123 HDAC5 10014
Affinity Capture-MS Homo sapiens
124 PPM1G 5496
Protein-peptide Homo sapiens
125 SETD7 80854
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
126 TAF6L 10629
Protein-peptide Homo sapiens
127 DAXX  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
128 KIF2C 11004
Protein-peptide Homo sapiens
129 FHDC1 85462
Cross-Linking-MS (XL-MS) Homo sapiens
130 ZNF516 9658
Biochemical Activity Homo sapiens
131 MGMT 4255
Affinity Capture-MS Homo sapiens
132 HIST1H2AI 8329
Cross-Linking-MS (XL-MS) Homo sapiens
133 msl-3  
Protein-peptide Drosophila melanogaster
134 ZMYM4  
Protein-peptide Homo sapiens
135 RING1 6015
Protein-peptide Homo sapiens
136 SOX6  
Cross-Linking-MS (XL-MS) Homo sapiens
137 TAF7  
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
138 HIST1H2AD 3013
Cross-Linking-MS (XL-MS) Homo sapiens
139 TAF12  
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
140 MIER1  
Protein-peptide Homo sapiens
141 ORC3  
Protein-peptide Homo sapiens
142 TAF15 8148
Protein-peptide Homo sapiens
143 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
144 FANCD2  
Cross-Linking-MS (XL-MS) Homo sapiens
145 KMT2A  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Protein-peptide Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
146 CDC73  
Affinity Capture-Western Homo sapiens
147 AHDC1  
Protein-peptide Homo sapiens
148 POP1 10940
Cross-Linking-MS (XL-MS) Homo sapiens
149 CBX8 57332
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
Protein-peptide Homo sapiens
150 MGA  
Protein-peptide Homo sapiens
151 NAT10 55226
Cross-Linking-MS (XL-MS) Homo sapiens
152 AHNAK 79026
Cross-Linking-MS (XL-MS) Homo sapiens
153 TAF1B  
Affinity Capture-MS Homo sapiens
154 SETD2  
Biochemical Activity Homo sapiens
155 PHF2  
Affinity Capture-Western Homo sapiens
156 ADNP 23394
Protein-peptide Homo sapiens
157 KIF2A 3796
Protein-peptide Homo sapiens
158 HNRNPA1 3178
Protein-peptide Homo sapiens
159 EPRS 2058
Cross-Linking-MS (XL-MS) Homo sapiens
160 CBX2  
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
Protein-peptide Homo sapiens
161 RBBP4 5928
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Protein-peptide Homo sapiens
162 TBP  
Protein-peptide Homo sapiens
163 AURKB 9212
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
164 KDM3B  
Biochemical Activity Homo sapiens
165 PRMT5 10419
Protein-peptide Homo sapiens
166 HIST1H1B 3009
Cross-Linking-MS (XL-MS) Homo sapiens
167 HNRNPAB 3182
Protein-peptide Homo sapiens
168 SUPT3H  
Protein-peptide Homo sapiens
169 FABP5 2171
Cross-Linking-MS (XL-MS) Homo sapiens
170 JAK1 3716
Biochemical Activity Homo sapiens
171 SET 6418
Reconstituted Complex Homo sapiens
172 ASF1A 25842
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
173 PHF21A  
Affinity Capture-Western Homo sapiens
174 EHMT2 10919
Biochemical Activity Homo sapiens
175 KAT5  
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
176 H2AFJ 55766
Cross-Linking-MS (XL-MS) Homo sapiens
177 PABPN1L  
Cross-Linking-MS (XL-MS) Homo sapiens
178 HIST1H1A 3024
Cross-Linking-MS (XL-MS) Homo sapiens
179 GPBP1  
Cross-Linking-MS (XL-MS) Homo sapiens
180 RNF2  
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
181 MORF4L1  
Protein-peptide Homo sapiens
182 HAT1 8520
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
183 RBBP5 5929
Biochemical Activity Homo sapiens
184 HIST1H1T 3010
Cross-Linking-MS (XL-MS) Homo sapiens
185 APLF  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
186 HIST1H2AJ 8331
Cross-Linking-MS (XL-MS) Homo sapiens
187 MDM2  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
188 SUPT20H 55578
Protein-peptide Homo sapiens
189 SUZ12  
Reconstituted Complex Homo sapiens
190 BIRC5  
Protein-peptide Homo sapiens
191 H2AFX 3014
Cross-Linking-MS (XL-MS) Homo sapiens
192 CBX4  
Biochemical Activity Homo sapiens
Protein-peptide Homo sapiens
193 HSP90AB1 3326
Cross-Linking-MS (XL-MS) Homo sapiens
194 TAF6 6878
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
195 TAF5  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
196 RPS27A 6233
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
197 RARA 5914
Affinity Capture-MS Homo sapiens
198 PARP1 142
Biochemical Activity Homo sapiens
199 SLC25A6 293
Cross-Linking-MS (XL-MS) Homo sapiens
200 KAT2A  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
201 TAF1A  
Reconstituted Complex Homo sapiens
202 H3F3A 3020
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
203 SIN3A  
Protein-peptide Homo sapiens
204 MBD3 53615
Protein-peptide Homo sapiens
205 TAF5L  
Protein-peptide Homo sapiens
206 ASF1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
207 KDM1B  
Biochemical Activity Homo sapiens
208 MCM5 4174
Affinity Capture-MS Homo sapiens
209 PHRF1  
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
210 PCGF6  
Protein-peptide Homo sapiens
211 KAT2B  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
212 CHAMP1  
Protein-peptide Homo sapiens
213 MEN1 4221
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
214 DPY30 84661
Protein-peptide Homo sapiens
215 UBA52 7311
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
216 PDHA1 5160
Affinity Capture-MS Homo sapiens
217 PHF8  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
218 NCOA2 10499
Biochemical Activity Homo sapiens
219 PTBP1 5725
Protein-peptide Homo sapiens
220 SMN1 6606
Protein-peptide Homo sapiens
221 PBRM1 55193
Affinity Capture-Luminescence Homo sapiens
222 CHD6 84181
Protein-peptide Homo sapiens
223 MTA1 9112
Protein-peptide Homo sapiens
224 HDAC1 3065
Biochemical Activity Homo sapiens
Protein-peptide Homo sapiens
225 CHD4 1108
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
226 HSP90AA1 3320
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
227 EIF4A3 9775
Affinity Capture-MS Homo sapiens
228 CREB1  
Affinity Capture-MS Homo sapiens
229 CDYL 9425
Protein-peptide Homo sapiens
230 H2AFY 9555
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-Western Homo sapiens
231 HNRNPK 3190
Protein-peptide Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
232 HDAC8 55869
Affinity Capture-Western Homo sapiens
233 PARP2  
Biochemical Activity Homo sapiens
234 HMGXB4 10042
Protein-peptide Homo sapiens
235 PRAME  
Affinity Capture-MS Homo sapiens
236 UBB 7314
Cross-Linking-MS (XL-MS) Homo sapiens
237 LRWD1  
Protein-peptide Homo sapiens
238 TRIM37  
Co-localization Homo sapiens
239 NOC2L 26155
Reconstituted Complex Homo sapiens
240 NCL 4691
Protein-peptide Homo sapiens
241 EZH2  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
242 HNRNPL 3191
Protein-peptide Homo sapiens
243 RIPPLY1  
Two-hybrid Homo sapiens
244 IPO4 79711
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
245 KDM5A  
Protein-peptide Homo sapiens
246 AIRE  
Affinity Capture-Western Homo sapiens
247 PRKCA 5578
Biochemical Activity Homo sapiens
248 DNM3 26052
Cross-Linking-MS (XL-MS) Homo sapiens
249 HIST1H2AB 8335
Cross-Linking-MS (XL-MS) Homo sapiens
250 DIDO1  
Cross-Linking-MS (XL-MS) Homo sapiens
Protein-peptide Homo sapiens
251 GLYR1 84656
Protein-peptide Homo sapiens
252 TAF13  
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
253 EHMT1  
Biochemical Activity Homo sapiens
254 ORC5  
Protein-peptide Homo sapiens
255 KAT6A  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
256 UHRF1 29128
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Protein-peptide Homo sapiens
Protein-peptide Homo sapiens
Protein-peptide Homo sapiens
Protein-peptide Homo sapiens
257 C9orf72  
Affinity Capture-MS Homo sapiens
258 GATAD1  
Protein-peptide Homo sapiens
259 PHC2  
Protein-peptide Homo sapiens
260 CHAF1B  
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
261 HNRNPA2B1 3181
Protein-peptide Homo sapiens
262 JAK2 3717
Biochemical Activity Homo sapiens
263 ING2  
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
264 RCOR1  
Biochemical Activity Homo sapiens
265 KDM5D  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Phenotypic Enhancement Homo sapiens
266 SGTA 6449
Cross-Linking-MS (XL-MS) Homo sapiens
267 EP300 2033
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
268 PPIB 5479
Protein-peptide Homo sapiens
View the network image/svg+xml
 Pathways in which HIST3H3 is involved
PathwayEvidenceSource
Base Excision Repair TAS Reactome
Base Excision Repair IEA Reactome
Base-Excision Repair, AP Site Formation TAS Reactome
Base-Excision Repair, AP Site Formation IEA Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Chromosome Maintenance TAS Reactome
Cleavage of the damaged purine TAS Reactome
Cleavage of the damaged purine IEA Reactome
Cleavage of the damaged pyrimidine IEA Reactome
Condensation of Prophase Chromosomes TAS Reactome
Depurination TAS Reactome
Depurination IEA Reactome
Depyrimidination IEA Reactome
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
DNA Double Strand Break Response TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA Repair TAS Reactome
DNA Repair IEA Reactome
Formation of the beta-catenin:TCF transactivating complex TAS Reactome
Formation of the beta-catenin:TCF transactivating complex IEA Reactome
G2/M Checkpoints TAS Reactome
G2/M DNA damage checkpoint TAS Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) TAS Reactome
Homology Directed Repair TAS Reactome
Inhibition of DNA recombination at telomere TAS Reactome
M Phase TAS Reactome
Meiosis IEA Reactome
Meiotic recombination IEA Reactome
Meiotic synapsis IEA Reactome
Mitotic Prophase TAS Reactome
Nonhomologous End-Joining (NHEJ) TAS Reactome
Packaging Of Telomere Ends TAS Reactome
Processing of DNA double-strand break ends TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected pyrimidine IEA Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TAS Reactome
Reproduction IEA Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by WNT TAS Reactome
Signaling by WNT IEA Reactome
TCF dependent signaling in response to WNT TAS Reactome
TCF dependent signaling in response to WNT IEA Reactome
Telomere Maintenance TAS Reactome





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