Gene description for HDAC8
Gene name	histone deacetylase 8
Gene symbol	HDAC8
Other names/aliases	CDA07 CDLS5 HD8 HDACL1 MRXS6 RPD3 WTS
Species	Homo sapiens
Database cross references - HDAC8
ExoCarta	ExoCarta_55869
Vesiclepedia	VP_55869
Entrez Gene	55869
HGNC	13315
MIM	300269
UniProt	Q9BY41
HDAC8 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for HDAC8

Molecular Function     histone deacetylase activity GO:0004407 IBA     histone deacetylase activity GO:0004407 IDA     histone deacetylase activity GO:0004407 TAS     protein binding GO:0005515 IPI     Hsp70 protein binding GO:0030544 IPI     histone H3K14 deacetylase activity, hydrolytic mechanism GO:0031078 IEA     histone H3K9 deacetylase activity, hydrolytic mechanism GO:0032129 IEA     protein lysine deacetylase activity GO:0033558 IDA     histone H4K16 deacetylase activity, hydrolytic mechanism GO:0034739 IEA     tubulin deacetylase activity GO:0042903 IEA     metal ion binding GO:0046872 IEA     Hsp90 protein binding GO:0051879 IPI     DNA-binding transcription factor binding GO:0140297 TAS     histone H4K12 deacetylase activity, hydrolytic mechanism GO:0140937 IEA     histone decrotonylase activity GO:0160009 IDA     histone H4K5 deacetylase activity, hydrolytic mechanism GO:0180032 IEA     histone H4K8 deacetylase activity, hydrolytic mechanism GO:0180033 IEA     histone H3K4 deacetylase activity, hydrolytic mechanism GO:1990162 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 TAS     chromatin organization GO:0006325 TAS     mitotic sister chromatid cohesion GO:0007064 IMP     negative regulation of protein ubiquitination GO:0031397 IDA     heterochromatin formation GO:0031507 IBA     regulation of protein stability GO:0031647 IDA     regulation of telomere maintenance GO:0032204 IMP Subcellular Localization     histone deacetylase complex GO:0000118 TAS     nuclear chromosome GO:0000228 TAS     nucleus GO:0005634 TAS     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 TAS