Gene description for DOT1L
Gene name	DOT1-like histone H3K79 methyltransferase
Gene symbol	DOT1L
Other names/aliases	DOT1 KMT4
Species	Homo sapiens
Database cross references - DOT1L
ExoCarta	ExoCarta_84444
Vesiclepedia	VP_84444
Entrez Gene	84444
HGNC	24948
MIM	607375
UniProt	Q8TEK3
DOT1L identified in sEVs derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for DOT1L

Molecular Function     nucleic acid binding GO:0003676 EXP     DNA binding GO:0003677 IEA     transcription coactivator activity GO:0003713 IMP     protein binding GO:0005515 IPI     histone H3K79 methyltransferase activity GO:0031151 IBA     histone H3K79 methyltransferase activity GO:0031151 IDA     histone H3K79 methyltransferase activity GO:0031151 IMP     histone methyltransferase activity GO:0042054 IDA     RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI     histone H3 methyltransferase activity GO:0140938 TAS     histone H3K79 trimethyltransferase activity GO:0140956 IEA Biological Process     DNA damage checkpoint signaling GO:0000077 IBA     DNA repair GO:0006281 IBA     gene expression GO:0010467 IEA     subtelomeric heterochromatin formation GO:0031509 IBA     telomere organization GO:0032200 TAS     methylation GO:0032259 IEA     positive regulation of DNA-templated transcription GO:0045893 IEA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     regulation of receptor signaling pathway via JAK-STAT GO:0046425 IDA     regulation of transcription regulatory region DNA binding GO:2000677 IMP Subcellular Localization     chromosome, telomeric region GO:0000781 IEA     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IEA     protein-containing complex GO:0032991 IDA     intracellular membrane-bounded organelle GO:0043231 IDA