Gene description for TOPBP1
Gene name	topoisomerase (DNA) II binding protein 1
Gene symbol	TOPBP1
Other names/aliases	TOP2BP1
Species	Homo sapiens
Database cross references - TOPBP1
ExoCarta	ExoCarta_11073
Vesiclepedia	VP_11073
Entrez Gene	11073
HGNC	17008
MIM	607760
UniProt	Q92547
TOPBP1 identified in sEVs derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for TOPBP1

Molecular Function     DNA binding GO:0003677 IEA     protein binding GO:0005515 IPI     identical protein binding GO:0042802 IPI     protein serine/threonine kinase activator activity GO:0043539 IDA     phosphorylation-dependent protein binding GO:0140031 IDA     chromatin-protein adaptor activity GO:0140463 IDA Biological Process     DNA replication checkpoint signaling GO:0000076 IDA     DNA damage checkpoint signaling GO:0000077 IDA     double-strand break repair via homologous recombination GO:0000724 IDA     DNA metabolic process GO:0006259 TAS     DNA replication initiation GO:0006270 IBA     DNA repair GO:0006281 NAS     chromatin organization GO:0006325 IEA     DNA damage response GO:0006974 IDA     mitotic G2 DNA damage checkpoint signaling GO:0007095 IBA     response to ionizing radiation GO:0010212 IDA     mitotic DNA replication checkpoint signaling GO:0033314 IBA     homologous recombination GO:0035825 NAS     chromosome organization GO:0051276 IDA     double-strand break repair via classical nonhomologous end joining GO:0097680 IDA     double-strand break repair via alternative nonhomologous end joining GO:0097681 IDA     broken chromosome clustering GO:0141112 IDA     protein localization to site of double-strand break GO:1990166 IDA Subcellular Localization     condensed nuclear chromosome GO:0000794 IEA     spindle pole GO:0000922 IEA     male germ cell nucleus GO:0001673 IEA     nucleus GO:0005634 NAS     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     chromosome GO:0005694 IDA     chromosome GO:0005694 IDA     cytoplasm GO:0005737 IEA     centrosome GO:0005813 IEA     plasma membrane GO:0005886 IDA     actin cytoskeleton GO:0015629 IDA     nuclear body GO:0016604 IDA     PML body GO:0016605 IDA     site of double-strand break GO:0035861 IDA     BRCA1-B complex GO:0070532 IPI     site of DNA damage GO:0090734 IDA