Gene description for RPL22
Gene name ribosomal protein L22
Gene symbol RPL22
Other names/aliases EAP
HBP15
HBP15/L22
L22
Species Homo sapiens
 Database cross references - RPL22
ExoCarta ExoCarta_6146
Vesiclepedia VP_6146
Entrez Gene 6146
HGNC 10315
MIM 180474
UniProt P35268  
 RPL22 identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
T lymphocytes 34108659    
Thymus 23844026    
 Gene ontology annotations for RPL22
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IBA
    structural constituent of ribosome GO:0003735 IBA
    structural constituent of ribosome GO:0003735 IDA
    structural constituent of ribosome GO:0003735 NAS
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IEA
    identical protein binding GO:0042802 IPI
Biological Process
    cytoplasmic translation GO:0002181 IBA
    cytoplasmic translation GO:0002181 IC
    translation GO:0006412 NAS
    alpha-beta T cell differentiation GO:0046632 IEA
    translation at presynapse GO:0140236 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    focal adhesion GO:0005925 HDA
    cytosolic large ribosomal subunit GO:0022625 HDA
    cytosolic large ribosomal subunit GO:0022625 IDA
    cytosolic ribosome GO:0022626 IDA
    extracellular exosome GO:0070062 HDA
    presynapse GO:0098793 IEA
    glutamatergic synapse GO:0098978 IEA
    ribonucleoprotein complex GO:1990904 IDA
 Experiment description of studies that identified RPL22 in sEVs
1
Experiment ID 79
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 412
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
4
Experiment ID 414
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 494
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 498
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 1203
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
12
Experiment ID 407
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
13
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 405
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
18
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 417
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
22
Experiment ID 411
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
23
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
24
Experiment ID 418
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 413
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 406
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 415
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
28
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
29
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
30
Experiment ID 408
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
31
Experiment ID 409
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
32
Experiment ID 416
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
33
Experiment ID 834
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
34
Experiment ID 835
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
35
Experiment ID 410
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
36
Experiment ID 217
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RPL22
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNL2 29889
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 CENPB 1059
Affinity Capture-MS Homo sapiens
4 EMC4 51234
Affinity Capture-MS Homo sapiens
5 RPSA 3921
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
6 LUZP4  
Affinity Capture-MS Homo sapiens
7 RPL26L1 51121
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
8 RSBN1L  
Affinity Capture-MS Homo sapiens
9 SPRTN  
Affinity Capture-MS Homo sapiens
10 UBL4A 8266
Affinity Capture-MS Homo sapiens
11 RPS3A 6189
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
12 NCAPH 23397
Affinity Capture-MS Homo sapiens
13 EIF2S3 1968
Affinity Capture-MS Homo sapiens
14 RPS4X 6191
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
15 RPL30 6156
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
16 RIN3  
Affinity Capture-MS Homo sapiens
17 SRPK2 6733
Biochemical Activity Homo sapiens
18 CWC22 57703
Affinity Capture-MS Homo sapiens
19 TARDBP 23435
Affinity Capture-MS Homo sapiens
20 HIST1H1D 3007
Cross-Linking-MS (XL-MS) Homo sapiens
21 BTF3 689
Affinity Capture-MS Homo sapiens
22 CD4 920
Affinity Capture-MS Homo sapiens
23 RPL13A 23521
Co-fractionation Homo sapiens
24 RPL37A 6168
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
25 TMEM147 10430
Affinity Capture-MS Homo sapiens
26 EBNA-LP  
Affinity Capture-MS
27 FBXL19  
Affinity Capture-MS Homo sapiens
28 NOP56 10528
Affinity Capture-MS Homo sapiens
29 NMNAT1  
Affinity Capture-MS Homo sapiens
30 RPS19 6223
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
31 RPL10 6134
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
32 RPL15 6138
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
33 RPL14 9045
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Co-fractionation Homo sapiens
34 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
35 CALM1 801
Reconstituted Complex Homo sapiens
36 CAND1 55832
Affinity Capture-MS Homo sapiens
37 Actb 11461
Affinity Capture-MS Mus musculus
38 Ktn1  
Affinity Capture-MS Mus musculus
39 RPS3 6188
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
40 ATG13 9776
Affinity Capture-MS Homo sapiens
41 KIAA1429 25962
Affinity Capture-MS Homo sapiens
42 VANGL2  
Affinity Capture-MS Homo sapiens
43 RPL4 6124
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
44 RPS20 6224
Co-fractionation Homo sapiens
45 METAP2 10988
Affinity Capture-MS Homo sapiens
46 WDR76  
Affinity Capture-MS Homo sapiens
47 PINK1  
Affinity Capture-MS Homo sapiens
48 B3GNT2 10678
Affinity Capture-MS Homo sapiens
49 RPL7A 6130
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
50 PRC1 9055
Affinity Capture-MS Homo sapiens
51 KIF23 9493
Affinity Capture-MS Homo sapiens
52 MCM2 4171
Affinity Capture-MS Homo sapiens
53 EIF3B 8662
Affinity Capture-MS Homo sapiens
54 COPS5 10987
Affinity Capture-MS Homo sapiens
55 FBXW7  
Affinity Capture-MS Homo sapiens
56 RPL24 6152
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
57 CALD1 800
Affinity Capture-MS Homo sapiens
58 NDUFA5 4698
Cross-Linking-MS (XL-MS) Homo sapiens
59 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
60 DDX24 57062
Affinity Capture-MS Homo sapiens
61 POU5F1  
Affinity Capture-RNA Homo sapiens
Affinity Capture-MS Homo sapiens
62 HEXB 3074
Co-fractionation Homo sapiens
63 MAPK14 1432
Two-hybrid Homo sapiens
64 SRP19 6728
Affinity Capture-MS Homo sapiens
65 RPS9 6203
Co-fractionation Homo sapiens
66 ABCE1 6059
Affinity Capture-MS Homo sapiens
67 PRKRA 8575
Affinity Capture-MS Homo sapiens
68 DDX51  
Affinity Capture-MS Homo sapiens
69 ITGA4 3676
Affinity Capture-MS Homo sapiens
70 EED  
Affinity Capture-MS Homo sapiens
71 ATG7 10533
Affinity Capture-MS Homo sapiens
72 LOC101929876 101929876
Co-fractionation Homo sapiens
73 ZCCHC10  
Two-hybrid Homo sapiens
74 VCAM1 7412
Affinity Capture-MS Homo sapiens
75 CEP57  
Affinity Capture-MS Homo sapiens
76 METTL14  
Affinity Capture-MS Homo sapiens
77 MECP2 4204
Affinity Capture-MS Homo sapiens
78 NSFL1C 55968
Two-hybrid Homo sapiens
79 CUL1 8454
Affinity Capture-MS Homo sapiens
80 ARIH2 10425
Affinity Capture-MS Homo sapiens
81 RBM42  
Affinity Capture-MS Homo sapiens
82 SDCBP 6386
Two-hybrid Homo sapiens
83 RPS11 6205
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
84 SREK1 140890
Affinity Capture-MS Homo sapiens
85 RPL19 6143
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
86 DYNLT1 6993
Proximity Label-MS Homo sapiens
87 KIF14 9928
Affinity Capture-MS Homo sapiens
88 RPL10L 140801
Co-fractionation Homo sapiens
89 RPS14 6208
Co-fractionation Homo sapiens
90 FOXP1 27086
Protein-RNA Homo sapiens
91 TPT1 7178
Affinity Capture-MS Homo sapiens
92 EMC9  
Affinity Capture-MS Homo sapiens
93 PSME3 10197
Affinity Capture-MS Homo sapiens
94 PDZD8 118987
Affinity Capture-MS Homo sapiens
95 BRIX1 55299
Affinity Capture-MS Homo sapiens
96 AURKA 6790
Affinity Capture-MS Homo sapiens
97 RRP1B 23076
Affinity Capture-MS Homo sapiens
98 RPL27 6155
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
99 DDX31  
Affinity Capture-MS Homo sapiens
100 YBX1 4904
Affinity Capture-MS Homo sapiens
101 RPS26 6231
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
102 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
103 TOP3B 8940
Affinity Capture-MS Homo sapiens
104 RPL9 6133
Co-fractionation Homo sapiens
105 GSPT1 2935
Affinity Capture-MS Homo sapiens
106 AP2M1 1173
Two-hybrid Homo sapiens
107 STAC3  
Two-hybrid Homo sapiens
108 PARK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 RBM28 55131
Affinity Capture-MS Homo sapiens
110 WDR89  
Affinity Capture-MS Homo sapiens
111 DDX21 9188
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 STAU1 6780
Affinity Capture-MS Homo sapiens
113 SNAPC4  
Affinity Capture-MS Homo sapiens
114 SRRM2 23524
Affinity Capture-MS Homo sapiens
115 VRK1 7443
Affinity Capture-MS Homo sapiens
116 RPL5 6125
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
117 RPL18A 6142
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
118 ZCCHC17  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 Srp72  
Affinity Capture-MS Mus musculus
120 CHMP4B 128866
Affinity Capture-MS Homo sapiens
121 TNRC18  
Affinity Capture-MS Homo sapiens
122 MYH9 4627
Affinity Capture-MS Homo sapiens
123 VCP 7415
Affinity Capture-MS Homo sapiens
124 HECTD1 25831
Affinity Capture-MS Homo sapiens
125 OGT 8473
Reconstituted Complex Homo sapiens
126 RPL31 6160
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
127 RPS7 6201
Co-fractionation Homo sapiens
128 RPS24 6229
Co-fractionation Homo sapiens
129 HIST1H1E 3008
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
130 BEND7 222389
Two-hybrid Homo sapiens
131 RPS10 6204
Co-fractionation Homo sapiens
132 LUC7L2 51631
Co-fractionation Homo sapiens
133 HUWE1 10075
Affinity Capture-MS Homo sapiens
134 HIST1H1C 3006
Cross-Linking-MS (XL-MS) Homo sapiens
135 RPL27A 6157
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
136 DHFRL1  
Proximity Label-MS Homo sapiens
137 RPS6 6194
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
138 Coro1c 23790
Affinity Capture-MS Mus musculus
139 ENY2 56943
Affinity Capture-MS Homo sapiens
140 SNAPC1  
Affinity Capture-MS Homo sapiens
141 RPLP0 6175
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
142 CEP76  
Affinity Capture-MS Homo sapiens
143 RPLP0P6 220717
Co-fractionation Homo sapiens
144 EPB41L5 57669
Affinity Capture-MS Homo sapiens
145 SRP68 6730
Affinity Capture-MS Homo sapiens
146 DDX27 55661
Affinity Capture-MS Homo sapiens
147 Ksr1  
Affinity Capture-MS Mus musculus
148 SEC61B 10952
Affinity Capture-MS Homo sapiens
149 RAD21 5885
Affinity Capture-Western Homo sapiens
150 NFX1  
Affinity Capture-MS Homo sapiens
151 ARFGAP1 55738
Co-fractionation Homo sapiens
152 HMGB2 3148
Affinity Capture-MS Homo sapiens
153 RPL11 6135
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
154 ANLN 54443
Affinity Capture-MS Homo sapiens
155 TRIM21 6737
Affinity Capture-MS Homo sapiens
156 RPL37 6167
Co-fractionation Homo sapiens
157 CT45A1  
Two-hybrid Homo sapiens
158 EIF3G 8666
Affinity Capture-MS Homo sapiens
159 ATG4B 23192
Affinity Capture-MS Homo sapiens
160 RPL32 6161
Affinity Capture-MS Homo sapiens
161 DDX6 1656
Affinity Capture-MS Homo sapiens
162 RBM39 9584
Affinity Capture-MS Homo sapiens
163 EFNA4  
Affinity Capture-MS Homo sapiens
164 RPLP2 6181
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
165 FANCD2  
Affinity Capture-MS Homo sapiens
166 NOC3L 64318
Affinity Capture-MS Homo sapiens
167 CDC73  
Affinity Capture-MS Homo sapiens
168 TRIM31  
Affinity Capture-MS Homo sapiens
169 RPS2 6187
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
170 KIF20A 10112
Affinity Capture-MS Homo sapiens
171 RC3H2  
Affinity Capture-MS Homo sapiens
172 ECT2 1894
Affinity Capture-MS Homo sapiens
173 ZBTB24  
Affinity Capture-MS Homo sapiens
174 DNAJC2 27000
Affinity Capture-MS Homo sapiens
175 RPL35 11224
Co-fractionation Homo sapiens
176 Ccdc9  
Affinity Capture-MS Mus musculus
177 CTCF  
Affinity Capture-MS Homo sapiens
178 UBC 7316
Affinity Capture-MS Homo sapiens
179 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
180 Rrbp1  
Affinity Capture-MS Mus musculus
181 RPL21 6144
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
182 RPL3 6122
Co-fractionation Homo sapiens
183 EGFR 1956
Affinity Capture-MS Homo sapiens
184 THOC5 8563
Affinity Capture-MS Homo sapiens
185 Eif3a 13669
Affinity Capture-MS Mus musculus
186 ATP1B3 483
Co-fractionation Homo sapiens
187 BBX 56987
Affinity Capture-MS Homo sapiens
188 MYC  
Affinity Capture-MS Homo sapiens
189 RPL7 6129
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
190 SIN3B  
Affinity Capture-MS Homo sapiens
191 GTF3C4 9329
Co-fractionation Homo sapiens
192 FN1 2335
Affinity Capture-MS Homo sapiens
193 ZC3H10  
Affinity Capture-MS Homo sapiens
194 THAP1  
Two-hybrid Homo sapiens
195 CDC42 998
Two-hybrid Homo sapiens
196 STRAP 11171
Co-fractionation Homo sapiens
197 AURKB 9212
Affinity Capture-MS Homo sapiens
198 RPS27 6232
Co-fractionation Homo sapiens
199 CDK2 1017
Affinity Capture-MS Homo sapiens
200 RPL29 6159
Co-fractionation Homo sapiens
201 HSP90AA4P 3323
Co-fractionation Homo sapiens
202 RPL36 25873
Co-fractionation Homo sapiens
203 IL7R  
Protein-RNA Homo sapiens
204 Flnb 286940
Affinity Capture-MS Mus musculus
205 PSPC1 55269
Affinity Capture-MS Homo sapiens
206 BAG1 573
Affinity Capture-MS Homo sapiens
207 RPS13 6207
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
208 DHX30 22907
Affinity Capture-MS Homo sapiens
209 PHF6  
Affinity Capture-MS Homo sapiens
210 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
211 RPL26 6154
Co-fractionation Homo sapiens
212 RPL35A 6165
Co-fractionation Homo sapiens
213 RPL12 6136
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
214 SCAF11  
Cross-Linking-MS (XL-MS) Homo sapiens
215 RPL22 6146
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
216 MYCN  
Affinity Capture-MS Homo sapiens
217 URB1 9875
Affinity Capture-MS Homo sapiens
218 UBTF 7343
Affinity Capture-MS Homo sapiens
219 RPL18 6141
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
220 DDRGK1 65992
Affinity Capture-MS Homo sapiens
221 RNF2  
Affinity Capture-MS Homo sapiens
222 RPS18 6222
Co-fractionation Homo sapiens
223 Rpl35 66489
Affinity Capture-MS Mus musculus
224 NAF1  
Affinity Capture-MS Homo sapiens
225 Eif3e 16341
Affinity Capture-MS Mus musculus
226 BMP4 652
Affinity Capture-MS Homo sapiens
227 PSMC5 5705
Cross-Linking-MS (XL-MS) Homo sapiens
228 FTSJ3 117246
Affinity Capture-MS Homo sapiens
229 HDGF 3068
Affinity Capture-MS Homo sapiens
230 CCDC8  
Affinity Capture-MS Homo sapiens
231 RPS16 6217
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
232 NIP7 51388
Affinity Capture-MS Homo sapiens
233 AHSA1 10598
Affinity Capture-MS Homo sapiens
234 RPL13 6137
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
235 DHX15 1665
Co-fractionation Homo sapiens
236 SURF6  
Two-hybrid Homo sapiens
237 RPS27A 6233
Co-fractionation Homo sapiens
238 ARRB2 409
Affinity Capture-MS Homo sapiens
239 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
240 FGF11  
Two-hybrid Homo sapiens
241 RPS25 6230
Co-fractionation Homo sapiens
242 ILF3 3609
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
243 CUL2 8453
Affinity Capture-MS Homo sapiens
244 RPL6 6128
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
245 CIT 11113
Affinity Capture-MS Homo sapiens
246 SDCBP2 27111
Two-hybrid Homo sapiens
247 TUBG1 7283
Affinity Capture-MS Homo sapiens
248 FOLR1 2348
Affinity Capture-MS Homo sapiens
249 SSB 6741
Affinity Capture-MS Homo sapiens
250 SRP14 6727
Affinity Capture-MS Homo sapiens
251 USP36  
Affinity Capture-MS Homo sapiens
252 RPS8 6202
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
253 RPS17 6218
Co-fractionation Homo sapiens
254 RPS21 6227
Co-fractionation Homo sapiens
255 CUL5 8065
Affinity Capture-MS Homo sapiens
256 RPS12 6206
Co-fractionation Homo sapiens
257 KNOP1 400506
Affinity Capture-MS Homo sapiens
258 HNRNPM 4670
Co-fractionation Homo sapiens
259 SMURF1 57154
Affinity Capture-MS Homo sapiens
260 HIST1H2BN 8341
Two-hybrid Homo sapiens
261 G3BP1 10146
Affinity Capture-MS Homo sapiens
262 SRP72 6731
Affinity Capture-MS Homo sapiens
263 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
264 CAPZB 832
Affinity Capture-MS Homo sapiens
265 G3BP2 9908
Affinity Capture-MS Homo sapiens
266 DDIT4L  
Two-hybrid Homo sapiens
267 RPS5 6193
Co-fractionation Homo sapiens
268 RPS15A 6210
Co-fractionation Homo sapiens
269 RPL34 6164
Co-fractionation Homo sapiens
270 CSE1L 1434
Two-hybrid Homo sapiens
271 TOP2A 7153
Affinity Capture-MS Homo sapiens
272 ESR1  
Affinity Capture-MS Homo sapiens
273 DRG1 4733
Affinity Capture-MS Homo sapiens
274 UFL1 23376
Affinity Capture-MS Homo sapiens
275 PRAME  
Affinity Capture-MS Homo sapiens
276 RPL10A 4736
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
277 HDGFRP2 84717
Co-fractionation Homo sapiens
278 NOC2L 26155
Affinity Capture-MS Homo sapiens
279 RPL38 6169
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
280 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
281 NCL 4691
Affinity Capture-MS Homo sapiens
282 GTPBP4 23560
Affinity Capture-MS Homo sapiens
283 RPS23 6228
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
284 EIF4B 1975
Affinity Capture-MS Homo sapiens
285 ARRB1 408
Affinity Capture-MS Homo sapiens
286 CYLD  
Affinity Capture-MS Homo sapiens
287 RPL23 9349
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
288 CBX8 57332
Affinity Capture-MS Homo sapiens
289 RBM8A 9939
Affinity Capture-MS Homo sapiens
290 CUL4A 8451
Affinity Capture-MS Homo sapiens
291 RPL8 6132
Co-fractionation Homo sapiens
292 RPS15 6209
Co-fractionation Homo sapiens
293 ZNF48  
Affinity Capture-MS Homo sapiens
294 RPS27L 51065
Co-fractionation Homo sapiens
295 SERBP1 26135
Affinity Capture-MS Homo sapiens
296 RPL23A 6147
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
297 KRAS 3845
Synthetic Lethality Homo sapiens
298 HNRNPU 3192
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
299 GNB2L1 10399
Affinity Capture-MS Homo sapiens
300 SRP9 6726
Affinity Capture-MS Homo sapiens
301 RC3H1 149041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
302 GGT1 2678
Cross-Linking-MS (XL-MS) Homo sapiens
303 VANGL1 81839
Affinity Capture-MS Homo sapiens
304 NUCKS1 64710
Affinity Capture-MS Homo sapiens
305 RPA3 6119
Proximity Label-MS Homo sapiens
306 NVL  
Affinity Capture-MS Homo sapiens
307 RPL17 6139
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
308 CCDC47 57003
Cross-Linking-MS (XL-MS) Homo sapiens
309 EIF5 1983
Affinity Capture-MS Homo sapiens
310 BOP1 23246
Affinity Capture-MS Homo sapiens
311 CEBPZ  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RPL22 is involved
PathwayEvidenceSource
Axon guidance IEA Reactome
Cap-dependent Translation Initiation TAS Reactome
Cellular response to starvation IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Eukaryotic Translation Elongation IEA Reactome
Eukaryotic Translation Initiation TAS Reactome
Eukaryotic Translation Termination IEA Reactome
Formation of a pool of free 40S subunits TAS Reactome
GTP hydrolysis and joining of the 60S ribosomal subunit TAS Reactome
Infectious disease TAS Reactome
Influenza Infection TAS Reactome
Influenza Viral RNA Transcription and Replication TAS Reactome
L13a-mediated translational silencing of Ceruloplasmin expression TAS Reactome
Major pathway of rRNA processing in the nucleolus and cytosol TAS Reactome
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome
Metabolism of proteins TAS Reactome
Metabolism of proteins IEA Reactome
Metabolism of RNA TAS Reactome
Nervous system development IEA Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) TAS Reactome
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) TAS Reactome
Nonsense-Mediated Decay (NMD) TAS Reactome
Peptide chain elongation IEA Reactome
Regulation of expression of SLITs and ROBOs IEA Reactome
Response of EIF2AK4 (GCN2) to amino acid deficiency IEA Reactome
rRNA processing TAS Reactome
rRNA processing in the nucleus and cytosol TAS Reactome
Selenoamino acid metabolism IEA Reactome
Selenocysteine synthesis IEA Reactome
Signaling by ROBO receptors IEA Reactome
SRP-dependent cotranslational protein targeting to membrane IEA Reactome
SRP-dependent cotranslational protein targeting to membrane TAS Reactome
Translation TAS Reactome
Translation IEA Reactome
Viral Infection Pathways TAS Reactome
Viral mRNA Translation TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here