Gene description for TBC1D24
Gene name TBC1 domain family, member 24
Gene symbol TBC1D24
Other names/aliases DFNA65
DFNB86
DOORS
EIEE16
FIME
TLDC6
Species Homo sapiens
 Database cross references - TBC1D24
ExoCarta ExoCarta_57465
Vesiclepedia VP_57465
Entrez Gene 57465
HGNC 29203
MIM 613577
UniProt Q9ULP9  
 TBC1D24 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Thymus 23844026    
 Gene ontology annotations for TBC1D24
Molecular Function
    GTPase activator activity GO:0005096 IEA
    protein binding GO:0005515 IPI
Biological Process
    dendrite development GO:0016358 IEA
    neuron projection development GO:0031175 IDA
    neuron projection development GO:0031175 IMP
    cellular response to oxidative stress GO:0034599 IDA
    synaptic vesicle endocytosis GO:0048488 IEA
    positive regulation of dendrite morphogenesis GO:0050775 IEA
    axon development GO:0061564 IEA
    negative regulation of cellular response to oxidative stress GO:1900408 IEA
    regulation of cilium assembly GO:1902017 IMP
    negative regulation of peptidyl-cysteine S-nitrosylation GO:1902083 IEA
    positive regulation of excitatory postsynaptic potential GO:2000463 IEA
    positive regulation of neuron migration GO:2001224 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    cell junction GO:0030054 IDA
    cytoplasmic vesicle membrane GO:0030659 IEA
    neuromuscular junction GO:0031594 ISS
    terminal bouton GO:0043195 ISS
 Experiment description of studies that identified TBC1D24 in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TBC1D24
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SDHD  
Affinity Capture-MS Homo sapiens
2 TNFAIP3 7128
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 TCEAL2  
Affinity Capture-MS Homo sapiens
4 GNG2 54331
Affinity Capture-MS Homo sapiens
5 Cyr61  
Affinity Capture-MS Mus musculus
6 RASSF8 11228
Affinity Capture-MS Homo sapiens
7 ADAT3 113179
Affinity Capture-MS Homo sapiens
8 CUL3 8452
Co-fractionation Homo sapiens
9 TP53 7157
Synthetic Growth Defect Homo sapiens
10 ATP6V1B2 526
Affinity Capture-MS Homo sapiens
11 PRNP 5621
Affinity Capture-MS Homo sapiens
12 ATP6V1G1 9550
Affinity Capture-MS Homo sapiens
13 NFKBIA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ATP6V1D 51382
Affinity Capture-MS Homo sapiens
15 FGB 2244
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 Shoc2  
Affinity Capture-MS Mus musculus
17 PARK2  
Affinity Capture-MS Homo sapiens
18 TLR1 7096
Affinity Capture-MS Homo sapiens
19 NTRK3 4916
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 RPA2 6118
Proximity Label-MS Homo sapiens
21 FAM46A  
Affinity Capture-MS Homo sapiens
22 EPHA2 1969
Proximity Label-MS Homo sapiens
23 ACBD7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 GPAM 57678
Affinity Capture-MS Homo sapiens
25 SLC6A5  
Affinity Capture-MS Homo sapiens
26 ATP6V1B1 525
Affinity Capture-MS Homo sapiens
27 Kctd5  
Affinity Capture-MS Mus musculus
28 OR5H1  
Affinity Capture-MS Homo sapiens
29 RPA3 6119
Proximity Label-MS Homo sapiens
30 DOCK3  
Affinity Capture-MS Homo sapiens
31 HUWE1 10075
Affinity Capture-MS Homo sapiens
32 S1PR4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 POU3F1  
Affinity Capture-MS Homo sapiens
34 TMEM185A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TBC1D24 is involved
PathwayEvidenceSource
Membrane Trafficking TAS Reactome
Rab regulation of trafficking TAS Reactome
TBC/RABGAPs TAS Reactome
Vesicle-mediated transport TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here