Gene description for IRF2BP1
Gene name interferon regulatory factor 2 binding protein 1
Gene symbol IRF2BP1
Other names/aliases -
Species Homo sapiens
 Database cross references - IRF2BP1
ExoCarta ExoCarta_26145
Vesiclepedia VP_26145
Entrez Gene 26145
HGNC 21728
MIM 615331
UniProt Q8IU81  
 IRF2BP1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for IRF2BP1
Molecular Function
    transcription corepressor activity GO:0003714 IBA
    transcription corepressor activity GO:0003714 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase activity GO:0061630 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    protein polyubiquitination GO:0000209 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified IRF2BP1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IRF2BP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KLF10  
Proximity Label-MS Homo sapiens
2 TLX1  
Proximity Label-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
5 ARHGAP1 392
Co-fractionation Homo sapiens
6 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
7 NMT1 4836
Affinity Capture-MS Homo sapiens
8 NPAS1  
Affinity Capture-MS Homo sapiens
9 PCBD2 84105
Two-hybrid Homo sapiens
10 IRF9 10379
Two-hybrid Homo sapiens
11 NFIB  
Proximity Label-MS Homo sapiens
12 DCP1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SOX6  
Proximity Label-MS Homo sapiens
14 BAG2 9532
Affinity Capture-MS Homo sapiens
15 PPP1R13L 10848
Affinity Capture-MS Homo sapiens
16 TBCE 6905
Affinity Capture-MS Homo sapiens
17 FARSA 2193
Co-fractionation Homo sapiens
18 UBE2L3 7332
Reconstituted Complex Homo sapiens
19 C1orf168  
Affinity Capture-MS Homo sapiens
20 KLF3  
Proximity Label-MS Homo sapiens
21 MLF1  
Affinity Capture-MS Homo sapiens
22 DNAJB1 3337
Co-fractionation Homo sapiens
23 CUL3 8452
Affinity Capture-MS Homo sapiens
24 NR3C1 2908
Proximity Label-MS Homo sapiens
25 QPRT 23475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 IRF2 3660
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
27 METTL21B  
Affinity Capture-MS Homo sapiens
28 PAX9  
Proximity Label-MS Homo sapiens
29 IRF2BPL 64207
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
30 HIP1R 9026
Co-fractionation Homo sapiens
31 FOSL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 PDE6D 5147
Affinity Capture-MS Homo sapiens
33 VGLL4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 DCTN3 11258
Affinity Capture-MS Homo sapiens
35 NFIX 4784
Proximity Label-MS Homo sapiens
36 ATF2  
Reconstituted Complex Homo sapiens
37 SMAD1 4086
Two-hybrid Homo sapiens
38 HNF4A  
Proximity Label-MS Homo sapiens
39 TRIM37  
Proximity Label-MS Homo sapiens
40 MBNL1 4154
Affinity Capture-MS Homo sapiens
41 IRF2BP1 26145
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 CCNL2 81669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 DNAI2  
Affinity Capture-MS Homo sapiens
44 NTRK1 4914
Affinity Capture-MS Homo sapiens
45 RFXANK  
Affinity Capture-MS Homo sapiens
46 TEAD1  
Proximity Label-MS Homo sapiens
47 HSPA1A 3303
Affinity Capture-MS Homo sapiens
48 PAX8  
Proximity Label-MS Homo sapiens
49 NUP35 129401
Proximity Label-MS Homo sapiens
50 SCRIB 23513
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 PRKY  
Affinity Capture-MS Homo sapiens
52 CTSB 1508
Co-fractionation Homo sapiens
53 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
54 KRAS 3845
Negative Genetic Homo sapiens
55 PML 5371
Affinity Capture-MS Homo sapiens
56 OBSL1 23363
Affinity Capture-MS Homo sapiens
57 ELK3  
Proximity Label-MS Homo sapiens
58 KDM3A  
Co-fractionation Homo sapiens
59 IRF2BP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
60 CCT8L2  
Affinity Capture-MS Homo sapiens
61 SP7  
Proximity Label-MS Homo sapiens
62 NFATC2  
Affinity Capture-MS Homo sapiens
63 MKI67  
Affinity Capture-MS Homo sapiens
64 AGR2 10551
Co-fractionation Homo sapiens
65 JDP2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
66 EDRF1  
Affinity Capture-MS Homo sapiens
67 TATDN1 83940
Co-fractionation Homo sapiens
68 DNAJC13 23317
Affinity Capture-MS Homo sapiens
69 CEBPA  
Proximity Label-MS Homo sapiens
Protein-peptide Homo sapiens
View the network image/svg+xml
 Pathways in which IRF2BP1 is involved
No pathways found





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