Gene description for Tfrc
Gene name	transferrin receptor
Gene symbol	Tfrc
Other names/aliases	Trfr
Species	Rattus norvegicus
Database cross references - Tfrc
ExoCarta	ExoCarta_64678
Vesiclepedia	VP_64678
Entrez Gene	64678
Tfrc identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479

Gene ontology annotations for Tfrc

Molecular Function     double-stranded RNA binding GO:0003725 ISO     transferrin receptor activity GO:0004998 IDA     transferrin receptor activity GO:0004998 IEA     transferrin receptor activity GO:0004998 ISO     transferrin receptor activity GO:0004998 TAS     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 ISO     Hsp70 protein binding GO:0030544 IPI     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 ISO     protein-containing complex binding GO:0044877 ISO     protein-folding chaperone binding GO:0051087 IPI Biological Process     regulation of cell growth GO:0001558 ISO     response to hypoxia GO:0001666 IEP     positive regulation of protein phosphorylation GO:0001934 ISO     iron ion transport GO:0006826 IBA     iron ion transport GO:0006826 ISO     intracellular iron ion homeostasis GO:0006879 IBA     intracellular iron ion homeostasis GO:0006879 IEA     intracellular iron ion homeostasis GO:0006879 ISO     acute-phase response GO:0006953 IEP     response to nutrient GO:0007584 IEP     response to iron ion GO:0010039 IEP     response to manganese ion GO:0010042 IEP     positive regulation of gene expression GO:0010628 ISO     negative regulation of mitochondrial fusion GO:0010637 ISO     osteoclast differentiation GO:0030316 ISO     positive regulation of B cell proliferation GO:0030890 ISO     positive regulation of B cell proliferation GO:0030890 ISS     positive regulation of protein-containing complex assembly GO:0031334 ISO     receptor internalization GO:0031623 IEA     receptor internalization GO:0031623 ISO     receptor internalization GO:0031623 ISS     response to retinoic acid GO:0032526 IEP     positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO     transferrin transport GO:0033572 IEA     transferrin transport GO:0033572 ISO     intracellular signal transduction GO:0035556 ISO     positive regulation of T cell proliferation GO:0042102 ISO     positive regulation of T cell proliferation GO:0042102 ISS     regulation of cell population proliferation GO:0042127 ISO     negative regulation of apoptotic process GO:0043066 ISO     positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO     positive regulation of bone resorption GO:0045780 ISO     positive regulation of isotype switching GO:0045830 ISO     positive regulation of isotype switching GO:0045830 ISS     response to copper ion GO:0046688 IEP     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO     multicellular organismal-level iron ion homeostasis GO:0060586 ISO     cellular response to xenobiotic stimulus GO:0071466 ISO     regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 ISO     positive regulation of protein localization to nucleus GO:1900182 ISO     cellular response to leukemia inhibitory factor GO:1990830 ISO Subcellular Localization     extracellular region GO:0005576 ISO     extracellular space GO:0005615 IDA     endosome GO:0005768 ISO     early endosome GO:0005769 ISO     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISO     clathrin-coated pit GO:0005905 ISO     external side of plasma membrane GO:0009897 IBA     external side of plasma membrane GO:0009897 ISO     cell surface GO:0009986 IDA     cell surface GO:0009986 ISO     endosome membrane GO:0010008 ISO     membrane GO:0016020 ISO     basolateral plasma membrane GO:0016323 ISO     cytoplasmic vesicle GO:0031410 ISO     melanosome GO:0042470 IEA     intracellular membrane-bounded organelle GO:0043231 ISO     perinuclear region of cytoplasm GO:0048471 ISO     recycling endosome GO:0055037 ISO     recycling endosome membrane GO:0055038 IDA     extracellular exosome GO:0070062 ISO     postsynapse GO:0098794 ISO     postsynaptic recycling endosome membrane GO:0098944 IDA     glutamatergic synapse GO:0098978 IDA     HFE-transferrin receptor complex GO:1990712 ISO