Gene description for QKI
Gene name QKI, KH domain containing, RNA binding
Gene symbol QKI
Other names/aliases Hqk
QK
QK1
QK3
hqkI
Species Homo sapiens
 Database cross references - QKI
ExoCarta ExoCarta_9444
Vesiclepedia VP_9444
Entrez Gene 9444
HGNC 21100
MIM 609590
UniProt Q96PU8  
 QKI identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for QKI
Molecular Function
    DNA binding GO:0003677 IEA
    transcription coactivator activity GO:0003713 ISS
    RNA binding GO:0003723 HDA
    mRNA binding GO:0003729 IBA
    mRNA binding GO:0003729 IDA
    mRNA binding GO:0003729 ISS
    mRNA 3'-UTR binding GO:0003730 IDA
    mRNA 3'-UTR binding GO:0003730 IEA
    protein binding GO:0005515 IPI
    SH3 domain binding GO:0017124 IEA
    miRNA binding GO:0035198 IDA
    internal N(7)-methylguanine-containing RNA reader activity GO:0160089 IDA
Biological Process
    vasculogenesis GO:0001570 IEA
    spermatid development GO:0007286 IEA
    intracellular mRNA localization GO:0008298 IDA
    positive regulation of gene expression GO:0010628 IEA
    regulation of epithelial to mesenchymal transition GO:0010717 IDA
    microglia differentiation GO:0014004 ISS
    negative regulation of angiogenesis GO:0016525 IDA
    negative regulation of translation GO:0017148 IDA
    negative regulation of translation GO:0017148 IEA
    negative regulation of translation GO:0017148 ISS
    positive regulation of myelination GO:0031643 ISS
    negative regulation of type I interferon production GO:0032480 IDA
    vascular associated smooth muscle cell differentiation GO:0035886 IDA
    myelination GO:0042552 IEA
    long-chain fatty acid biosynthetic process GO:0042759 IEA
    positive regulation of cholesterol biosynthetic process GO:0045542 ISS
    regulation of macrophage differentiation GO:0045649 IDA
    negative regulation of macrophage differentiation GO:0045650 IDA
    positive regulation of DNA-templated transcription GO:0045893 IEA
    regulation of mRNA splicing, via spliceosome GO:0048024 IBA
    regulation of mRNA splicing, via spliceosome GO:0048024 IDA
    regulation of mRNA splicing, via spliceosome GO:0048024 ISS
    mRNA stabilization GO:0048255 IDA
    regulation of astrocyte differentiation GO:0048710 ISS
    positive regulation of oligodendrocyte differentiation GO:0048714 IEA
    mRNA transport GO:0051028 IDA
    negative regulation of cold-induced thermogenesis GO:0120163 ISS
    spliceosome-depend formation of circular RNA GO:0160091 IDA
    negative regulation of 3'-UTR-mediated mRNA stabilization GO:1905869 ISS
    myofibroblast contraction GO:1990764 IEA
    negative regulation of miRNA catabolic process GO:2000626 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 IEA
    cytoplasmic stress granule GO:0010494 IDA
    cytoplasmic stress granule GO:0010494 IEA
    synapse GO:0045202 IEA
 Experiment description of studies that identified QKI in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for QKI
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RALY 22913
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 SLC39A12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 Mrpl13  
Two-hybrid Mus musculus
4 HNRNPC 3183
Affinity Capture-MS Homo sapiens
5 PCGF5  
Two-hybrid Homo sapiens
6 SECISBP2  
Two-hybrid Homo sapiens
7 RBPMS 11030
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
8 ELAVL2 1993
Affinity Capture-MS Homo sapiens
9 MED1 5469
Affinity Capture-MS Homo sapiens
10 YTHDF1 54915
Two-hybrid Homo sapiens
11 TNPO1 3842
Affinity Capture-MS Homo sapiens
12 MED29  
Affinity Capture-MS Homo sapiens
13 QKI 9444
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
14 TEX11  
Two-hybrid Homo sapiens
15 TSG101 7251
Two-hybrid Homo sapiens
16 Rbm47  
Two-hybrid Mus musculus
17 IGF2BP1 10642
Affinity Capture-MS Homo sapiens
18 HNRNPCL1 343069
Affinity Capture-MS Homo sapiens
19 FUBP3 8939
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
20 MED24 9862
Affinity Capture-MS Homo sapiens
21 UNKL  
Two-hybrid Homo sapiens
22 SOX2  
Affinity Capture-MS Homo sapiens
23 APP 351
Reconstituted Complex Homo sapiens
24 PCBP3 54039
Two-hybrid Homo sapiens
25 Pum2  
Two-hybrid Mus musculus
26 APEX1 328
Affinity Capture-RNA Homo sapiens
27 EIF4ENIF1 56478
Two-hybrid Homo sapiens
28 MED13 9969
Affinity Capture-MS Homo sapiens
29 TNRC6A 27327
Two-hybrid Homo sapiens
30 HSPA2 3306
Affinity Capture-MS Homo sapiens
31 TRNAU1AP  
Two-hybrid Homo sapiens
32 NDUFA7 4701
Co-fractionation Homo sapiens
33 LSM5  
Two-hybrid Homo sapiens
34 C8orf82  
Proximity Label-MS Homo sapiens
35 CALD1 800
Two-hybrid Homo sapiens
36 CPSF7 79869
Two-hybrid Homo sapiens
37 Hnrnpk 15387
Two-hybrid Mus musculus
38 SNRPC 6631
Two-hybrid Homo sapiens
39 OIP5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 HNRNPUL2 221092
Affinity Capture-MS Homo sapiens
41 MED17  
Affinity Capture-MS Homo sapiens
42 TIAL1 7073
Two-hybrid Homo sapiens
43 SERF2 10169
Two-hybrid Homo sapiens
44 MED27  
Affinity Capture-MS Homo sapiens
45 MYCN  
Affinity Capture-MS Homo sapiens
46 RBM42  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
47 PRKAB2 5565
Two-hybrid Homo sapiens
48 IL7 3574
Affinity Capture-MS Homo sapiens
49 FAM120A 23196
Affinity Capture-MS Homo sapiens
50 RBM14 10432
Two-hybrid Homo sapiens
51 NEIL3  
Protein-RNA Homo sapiens
52 MED4 29079
Affinity Capture-MS Homo sapiens
53 DMRTB1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
54 RBMX 27316
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 MED26  
Affinity Capture-MS Homo sapiens
56 PRPF6 24148
Two-hybrid Homo sapiens
57 HIST1H4A 8359
Cross-Linking-MS (XL-MS) Homo sapiens
58 FHL3 2275
Two-hybrid Homo sapiens
59 RPL9 6133
Two-hybrid Homo sapiens
60 ATE1 11101
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 RBFOX2 23543
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
62 ZMAT5  
Two-hybrid Homo sapiens
63 RBM7  
Two-hybrid Homo sapiens
64 THAP1  
Two-hybrid Homo sapiens
65 CARM1 10498
Two-hybrid Homo sapiens
66 SLAIN1 122060
Two-hybrid Homo sapiens
67 GATA3  
Proximity Label-MS Homo sapiens
68 NTRK1 4914
Affinity Capture-MS Homo sapiens
69 DAZ1  
Two-hybrid Homo sapiens
70 CENPM  
Affinity Capture-MS Homo sapiens
71 Ywhag 22628
Two-hybrid Mus musculus
72 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 TRIM11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 ANKHD1 54882
Two-hybrid Homo sapiens
75 SNRNP27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 TGM1 7051
Affinity Capture-MS Homo sapiens
77 MBNL2 10150
Two-hybrid Homo sapiens
78 TXNL4A 10907
Two-hybrid Homo sapiens
79 CCDC59  
Two-hybrid Homo sapiens
80 CEBPA  
Proximity Label-MS Homo sapiens
Protein-peptide Homo sapiens
81 ZACN  
Affinity Capture-MS Homo sapiens
82 HCLS1 3059
Two-hybrid Homo sapiens
83 MED15  
Affinity Capture-MS Homo sapiens
84 PCBP2 5094
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
85 USH1C  
Two-hybrid Homo sapiens
86 DUSP22  
Affinity Capture-MS Homo sapiens
87 ATXN1 6310
Two-hybrid Homo sapiens
88 MRPL44  
Two-hybrid Homo sapiens
89 CYB5B 80777
Affinity Capture-MS Homo sapiens
90 Rbm38  
Two-hybrid Mus musculus
91 BAG2 9532
Affinity Capture-MS Homo sapiens
92 PAX9  
Proximity Label-MS Homo sapiens
93 U2AF2 11338
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
94 HYPK 25764
Affinity Capture-MS Homo sapiens
95 CYP1A1  
Affinity Capture-MS Homo sapiens
96 RNF138  
Two-hybrid Homo sapiens
97 RBFOX1 54715
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
98 HNRNPA1 3178
Proximity Label-MS Homo sapiens
99 Hsp90aa1 15519
Two-hybrid Mus musculus
100 Pcbp1 23983
Two-hybrid Mus musculus
101 NIP7 51388
Two-hybrid Homo sapiens
102 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
103 ZC3H10  
Two-hybrid Homo sapiens
104 NXF1 10482
Two-hybrid Homo sapiens
105 PRR3  
Affinity Capture-MS Homo sapiens
106 PCBP4 57060
Two-hybrid Homo sapiens
107 MED10  
Affinity Capture-MS Homo sapiens
108 PCBP1 5093
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
109 Dusp14  
Two-hybrid Mus musculus
110 PIAS1 8554
Two-hybrid Homo sapiens
111 MYC  
Affinity Capture-MS Homo sapiens
112 BAG1 573
Affinity Capture-MS Homo sapiens
113 LSM3 27258
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
114 MSI2 124540
Two-hybrid Homo sapiens
115 HSPA1A 3303
Affinity Capture-MS Homo sapiens
116 MED23 9439
Affinity Capture-MS Homo sapiens
117 DDRGK1 65992
Affinity Capture-MS Homo sapiens
118 Pef1  
Two-hybrid Mus musculus
119 CDKN2D  
Two-hybrid Homo sapiens
120 POLR2A 5430
Affinity Capture-MS Homo sapiens
121 MED25  
Affinity Capture-MS Homo sapiens
122 MED14  
Affinity Capture-MS Homo sapiens
123 RBMS2 5939
Affinity Capture-MS Homo sapiens
124 BAG4  
Two-hybrid Homo sapiens
125 RBM11  
Two-hybrid Homo sapiens
126 ALG13 79868
Two-hybrid Homo sapiens
127 FN1 2335
Affinity Capture-MS Homo sapiens
128 KIF21B 23046
Two-hybrid Homo sapiens
129 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 HNRNPH2 3188
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
131 BCAS2 10286
Two-hybrid Homo sapiens
132 C10orf10  
Two-hybrid Homo sapiens
133 WDR77 79084
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
134 HSPA8 3312
Affinity Capture-MS Homo sapiens
135 VAC14 55697
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 MED31  
Affinity Capture-MS Homo sapiens
137 SNRPA 6626
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
138 NABP1  
Two-hybrid Homo sapiens
139 PTBP1 5725
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
140 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
141 PTBP2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
142 PRRC2B  
Two-hybrid Homo sapiens
143 HNRNPK 3190
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
144 YTHDF3  
Two-hybrid Homo sapiens
145 UFL1 23376
Affinity Capture-MS Homo sapiens
146 MED16 10025
Affinity Capture-MS Homo sapiens
147 RBM23  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
148 USP30  
Affinity Capture-MS Homo sapiens
149 MBNL1 4154
Two-hybrid Homo sapiens
150 MED12  
Affinity Capture-MS Homo sapiens
151 CDV3 55573
Co-fractionation Homo sapiens
152 HNRNPL 3191
Affinity Capture-MS Homo sapiens
153 PRPF39 55015
Two-hybrid Homo sapiens
154 HNRNPLL 92906
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
155 IL7R  
Protein-RNA Homo sapiens
156 PSMF1 9491
Two-hybrid Homo sapiens
157 DUSP4 1846
Affinity Capture-MS Homo sapiens
158 UTP6  
Two-hybrid Homo sapiens
159 SP7  
Proximity Label-MS Homo sapiens
160 FKBP2 2286
Co-fractionation Homo sapiens
161 CCND3  
Two-hybrid Homo sapiens
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