Gene description for LOC102724560
Gene name cystathionine beta-synthase
Gene symbol LOC102724560
Other names/aliases -
Species Homo sapiens
 Database cross references - LOC102724560
ExoCarta ExoCarta_102724560
Vesiclepedia VP_102724560
Entrez Gene 102724560
 LOC102724560 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for LOC102724560
Molecular Function
    cystathionine beta-synthase activity GO:0004122 IBA
    cystathionine beta-synthase activity GO:0004122 IDA
    protein binding GO:0005515 IPI
    oxygen binding GO:0019825 IDA
    enzyme binding GO:0019899 IPI
    heme binding GO:0020037 EXP
    heme binding GO:0020037 IDA
    heme binding GO:0020037 IMP
    pyridoxal phosphate binding GO:0030170 IDA
    ubiquitin protein ligase binding GO:0031625 IPI
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    metal ion binding GO:0046872 IEA
    nitrite reductase (NO-forming) activity GO:0050421 IDA
    carbon monoxide binding GO:0070025 IDA
    nitric oxide binding GO:0070026 IDA
    modified amino acid binding GO:0072341 IDA
    S-adenosyl-L-methionine binding GO:1904047 IDA
Biological Process
    endochondral ossification GO:0001958 IEA
    blood vessel remodeling GO:0001974 IEA
    cysteine biosynthetic process from serine GO:0006535 IBA
    L-serine metabolic process GO:0006563 IDA
    L-serine catabolic process GO:0006565 IDA
    superoxide metabolic process GO:0006801 IEA
    regulation of nitric oxide mediated signal transduction GO:0010749 IEA
    cysteine biosynthetic process via cystathionine GO:0019343 IEA
    cysteine biosynthetic process GO:0019344 IDA
    transsulfuration GO:0019346 IEA
    L-cysteine catabolic process GO:0019448 IDA
    cerebellum morphogenesis GO:0021587 IEA
    DNA protection GO:0042262 IMP
    negative regulation of apoptotic process GO:0043066 IEA
    homocysteine catabolic process GO:0043418 IDA
    homocysteine metabolic process GO:0050667 IDA
    response to folic acid GO:0051593 IEA
    maternal process involved in female pregnancy GO:0060135 IEA
    cartilage development involved in endochondral bone morphogenesis GO:0060351 IEA
    hydrogen sulfide biosynthetic process GO:0070814 IDA
    hydrogen sulfide biosynthetic process GO:0070814 ISS
    cellular response to hypoxia GO:0071456 IEA
    blood vessel diameter maintenance GO:0097746 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 HDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified LOC102724560 in sEVs
1
Experiment ID 211
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LOC102724560
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZMYM5 9205
Two-hybrid Homo sapiens
2 UFL1 23376
Affinity Capture-MS Homo sapiens
3 DDRGK1 65992
Affinity Capture-MS Homo sapiens
4 UBE2I 7329
Two-hybrid Homo sapiens
5 PRMT1 3276
Affinity Capture-MS Homo sapiens
6 OGT 8473
Reconstituted Complex Homo sapiens
7 KIF14 9928
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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