sEVs include 30-150 nm exosomes that is of endocytic origin and small ectosomes that are shed from the plasma membrane. ExoCarta, an sEV database, provides with the contents that were identified in sEVs in multiple organisms.

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (02/12/2020) from here

Vesiclepedia - Compendium on extracellular vesicles

External links of interest to the extracellular vesicle researchers

Want to contribute to ExoCarta?

We will keep ExoCarta updated with new sEV studies. We would love to have scientific community participation in any of the following ways.

Send unpublished sEV proteome/RNA/lipid datasets (it can be made private until published)
Point out an sEV publication that we missed

Contact us either to upload your sEV data or point to us if we have not added any published sEV study.

ExoCarta citation:

Keerthikumar, S., Chisanga, D., Ariyaratne, D., Al Saffar, H., Anand, S., Zhao, K., Samuel, M., Pathan, M., Jois, M., Chilamkurti, N., Gangoda, L. and Mathivanan, S. ExoCarta: A web-based compendium of exosomal cargo. Journal of Molecular Biology. 2015. PubMed

Simpson, R.J., Kalra, H. and Mathivanan, S. ExoCarta as a resource for exosomal research Journal of Extracellular Vesicles. 2012. PubMed

Mathivanan, S. Fahner, C.J., Reid, G.E., and Simpson, R.J. ExoCarta 2012: database of exosomal proteins, RNA and lipids. Nucleic Acids Research. 2012. PubMed

Mathivanan, S. and Simpson, R.J. ExoCarta: A compendium of exosomal proteins and RNA. Proteomics. 2009. 21, 4997-5000. PubMed

sEV reviews:

1. Simpson RJ and Mathivanan S. Extracellular Microvesicles: The Need for Internationally Recognised Nomenclature and Stringent Purification Criteria J Proteomics Bioinform. 2012. PubMed

2. Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009. 8, 581-93. PubMed

3. Keller S, Sanderson MP, Stoeck A, Altevogt P. Exosomes: from biogenesis and secretion to biological function. Immunol Lett. 2006. 2, 102-8. PubMed

4. Simpson RJ, Lim JW, Moritz RL, Mathivanan S. Exosomes: proteomic insights and diagnostic potential. Expert Rev Proteomics. 2009. 3, 267-83. PubMed

5. Record M, Subra C, Silvente-Poirot S, Poirot M. Exosomes as intercellular signalosomes and pharmacological effectors. Biochem Pharmacol. 2011.10, 1171-82. PubMed

6. Cocucci E, Racchetti G, Meldolesi J. Shedding microvesicles: artefacts no more. Trends Cell Biol. 2009. 2, 43-51. PubMed

7. Schorey JS, Bhatnagar S. Exosome function: from tumor immunology to pathogen biology. Traffic. 2008. 6, 871-81. PubMed

8. Mathivanan S, Ji H, Simpson RJ. Exosomes: Extracellular organelles important in intercellular communication. Journal of Proteomics. 2010. PubMed

9. van Niel G, Porto-Carreiro I, Simoes S, Raposo G. Exosomes: a common pathway for a specialized function. J Biochem. 2006. 1, 13-21. PubMed

10. Johnstone RM. Exosomes biological significance: A concise review. Blood Cells Mol Dis. 2006. 2, 315-21. PubMed

More exosome articles .....