Gene description for Synj1
Gene name synaptojanin 1
Gene symbol Synj1
Other names/aliases A930006D20Rik
AA675315
mKIAA0910
Species Mus musculus
 Database cross references - Synj1
ExoCarta ExoCarta_104015
Vesiclepedia VP_104015
Entrez Gene 104015
 Synj1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Synj1
Molecular Function
    RNA binding GO:0003723 IEA
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 ISO
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0004439 IBA
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0004439 IMP
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0004439 ISO
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0004439 ISS
    protein binding GO:0005515 IPI
    SH3 domain binding GO:0017124 ISO
    phosphatidylinositol phosphate 5-phosphatase activity GO:0034595 IMP
    phosphatidylinositol phosphate 5-phosphatase activity GO:0034595 ISO
    phosphatidylinositol-4-phosphate phosphatase activity GO:0043812 ISO
    protein-containing complex binding GO:0044877 ISO
    inositol-1,4,5-trisphosphate 5-phosphatase activity GO:0052658 IBA
    inositol-1,4,5-trisphosphate 5-phosphatase activity GO:0052658 ISO
    EH domain binding GO:1990175 ISO
Biological Process
    neurotransmitter transport GO:0006836 IMP
    learning GO:0007612 IMP
    learning GO:0007612 ISO
    positive regulation of gliogenesis GO:0014015 ISO
    synaptic vesicle priming GO:0016082 IMP
    synaptic vesicle uncoating GO:0016191 IDA
    synaptic vesicle uncoating GO:0016191 IMP
    synaptic vesicle uncoating GO:0016191 IMP
    response to retinoic acid GO:0032526 ISO
    response to cytokine GO:0034097 ISO
    phosphatidylinositol metabolic process GO:0046488 IMP
    phosphatidylinositol metabolic process GO:0046488 TAS
    phosphatidylinositol dephosphorylation GO:0046856 IMP
    phosphatidylinositol dephosphorylation GO:0046856 ISO
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    positive regulation of receptor-mediated endocytosis GO:0048260 ISO
    synaptic vesicle endocytosis GO:0048488 IBA
    synaptic vesicle endocytosis GO:0048488 IMP
    synaptic vesicle endocytosis GO:0048488 ISO
    synaptic vesicle transport GO:0048489 IMP
    regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 IDA
    regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 IMP
    positive regulation of synaptic vesicle recycling GO:1903423 TAS
    positive regulation of endosome organization GO:1904980 ISO
Subcellular Localization
    cytoplasm GO:0005737 IBA
    microtubule GO:0005874 ISO
    microtubule GO:0005874 ISS
    vesicle membrane GO:0012506 ISS
    membrane GO:0016020 IBA
    membrane GO:0016020 ISO
    membrane coat GO:0030117 IDA
    clathrin coat GO:0030118 TAS
    clathrin coat of coated pit GO:0030132 ISO
    clathrin coat of coated pit GO:0030132 ISS
    protein-containing complex GO:0032991 ISO
    terminal bouton GO:0043195 ISS
    perinuclear region of cytoplasm GO:0048471 IBA
    perinuclear region of cytoplasm GO:0048471 ISS
    synaptic membrane GO:0097060 ISO
    synaptic membrane GO:0097060 ISS
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IMP
    parallel fiber to Purkinje cell synapse GO:0098688 ISO
    presynapse GO:0098793 IBA
    presynapse GO:0098793 ISO
    presynapse GO:0098793 ISO
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified Synj1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Synj1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ap2a1 11771
Co-fractionation Mus musculus
2 Dnm1 13429
Co-fractionation Mus musculus
3 Kctd13  
Affinity Capture-MS Mus musculus
4 Mettl21e  
Affinity Capture-MS Mus musculus
5 Syngap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
6 Sh3gl2  
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
7 Eed  
Affinity Capture-MS Mus musculus
8 Atg5  
Affinity Capture-MS Mus musculus
9 Dlg4  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
10 Mapt  
Affinity Capture-MS Mus musculus
11 Agap2  
Affinity Capture-MS Mus musculus
12 Cltc 67300
Co-fractionation Mus musculus
13 Park2  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
View the network image/svg+xml
 Pathways in which Synj1 is involved
No pathways found





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