Gene description for LRRN2
Gene name leucine rich repeat neuronal 2
Gene symbol LRRN2
Other names/aliases FIGLER7
GAC1
LRANK1
LRRN5
Species Homo sapiens
 Database cross references - LRRN2
ExoCarta ExoCarta_10446
Vesiclepedia VP_10446
Entrez Gene 10446
HGNC 16914
MIM 605492
UniProt O75325  
 LRRN2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for LRRN2
Molecular Function
    signaling receptor activity GO:0038023 TAS
Biological Process
    cell adhesion GO:0007155 TAS
    signal transduction GO:0007165 TAS
Subcellular Localization
    extracellular space GO:0005615 IBA
    membrane GO:0016020 IEA
    extracellular matrix GO:0031012 IBA
 Experiment description of studies that identified LRRN2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LRRN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LRIG3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ZNF669  
Affinity Capture-MS Homo sapiens
3 BIRC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 BTNL2  
Affinity Capture-MS Homo sapiens
5 XIAP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TRAF2 7186
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 FGFR1 2260
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 GYLTL1B 120071
Affinity Capture-MS Homo sapiens
9 PTPRD 5789
Affinity Capture-MS Homo sapiens
10 ATP1A3 478
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 ATF6  
Affinity Capture-MS Homo sapiens
12 USP22 23326
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 NDFIP1 80762
Affinity Capture-MS Homo sapiens
14 NEUROD4  
Two-hybrid Homo sapiens
15 CLEC4A  
Affinity Capture-MS Homo sapiens
16 ETNK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 SFTPC  
Affinity Capture-MS Homo sapiens
18 DNAJC18  
Affinity Capture-MS Homo sapiens
19 ST7L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TRIM13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 FBXO11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 USP33  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LRRN2 is involved
No pathways found





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