Gene description for MXD4
Gene name MAX dimerization protein 4
Gene symbol MXD4
Other names/aliases MAD4
MST149
MSTP149
bHLHc12
Species Homo sapiens
 Database cross references - MXD4
ExoCarta ExoCarta_10608
Vesiclepedia VP_10608
Entrez Gene 10608
HGNC 13906
UniProt Q14582  
 MXD4 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MXD4
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    protein binding GO:0005515 IPI
    protein dimerization activity GO:0046983 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified MXD4 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MXD4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Max  
Affinity Capture-MS Mus musculus
2 SMC3 9126
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
3 Trappc11  
Affinity Capture-MS Mus musculus
4 TCP10L  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
5 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
6 SHBG 6462
Two-hybrid Homo sapiens
7 MAX  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
8 ASXL1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
9 MLX  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml



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