Gene description for FGL2
Gene name fibrinogen-like 2
Gene symbol FGL2
Other names/aliases T49
pT49
Species Homo sapiens
 Database cross references - FGL2
ExoCarta ExoCarta_10875
Vesiclepedia VP_10875
Entrez Gene 10875
HGNC 3696
MIM 605351
UniProt Q14314  
 FGL2 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for FGL2
Molecular Function
    extracellular matrix structural constituent GO:0005201 RCA
    protein binding GO:0005515 IPI
Biological Process
    T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 IEA
    negative regulation of dendritic cell antigen processing and presentation GO:0002605 IEA
    negative regulation of macrophage antigen processing and presentation GO:0002617 IEA
    negative regulation of memory T cell differentiation GO:0043381 IEA
    negative regulation of defense response to virus GO:0050687 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    fibrinogen complex GO:0005577 TAS
    extracellular space GO:0005615 IBA
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 IBA
    extracellular exosome GO:0070062 HDA
    ficolin-1-rich granule lumen GO:1904813 TAS
 Experiment description of studies that identified FGL2 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for FGL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GPX1 2876
Affinity Capture-MS Homo sapiens
2 ZNF282  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CDK5RAP2 55755
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 POP7  
Affinity Capture-MS Homo sapiens
5 FUT8 2530
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 PCNT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ITPR1 3708
Affinity Capture-MS Homo sapiens
8 GNPDA1 10007
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ITPR3 3710
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 SSFA2 6744
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 KIF7 374654
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CYLD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 MTFR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 SPATA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FGL2 is involved
PathwayEvidenceSource
Immune System TAS Reactome
Innate Immune System TAS Reactome
Neutrophil degranulation TAS Reactome





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