Gene description for PNRC1
Gene name proline-rich nuclear receptor coactivator 1
Gene symbol PNRC1
Other names/aliases B4-2
PNAS-145
PROL2
PRR2
Species Homo sapiens
 Database cross references - PNRC1
ExoCarta ExoCarta_10957
Vesiclepedia VP_10957
Entrez Gene 10957
HGNC 17278
MIM 606714
UniProt Q12796  
 PNRC1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PNRC1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 IBA
Subcellular Localization
    P-body GO:0000932 IBA
    nucleus GO:0005634 IBA
 Experiment description of studies that identified PNRC1 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PNRC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNF4G  
Two-hybrid Homo sapiens
2 UNK  
Affinity Capture-RNA Homo sapiens
3 DDX6 1656
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 NR5A2  
Two-hybrid Homo sapiens
5 HNF4A  
Two-hybrid Homo sapiens
6 ESR2  
Two-hybrid Homo sapiens
7 Edc4  
Affinity Capture-MS Mus musculus
8 DCP1A 55802
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 RARB  
Two-hybrid Homo sapiens
10 MAPK8 5599
Two-hybrid Homo sapiens
11 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
12 DCP1B  
Affinity Capture-MS Homo sapiens
13 CRKL 1399
Affinity Capture-MS Homo sapiens
14 RORA  
Two-hybrid Homo sapiens
15 RARG  
Two-hybrid Homo sapiens
16 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
17 RORB  
Two-hybrid Homo sapiens
18 ESRRG  
Two-hybrid Homo sapiens
19 CLTA 1211
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PNRC1 is involved
No pathways found





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