Gene description for SLC38A3
Gene name solute carrier family 38, member 3
Gene symbol SLC38A3
Other names/aliases G17
NAT1
SN1
SNAT3
Species Homo sapiens
 Database cross references - SLC38A3
ExoCarta ExoCarta_10991
Vesiclepedia VP_10991
Entrez Gene 10991
HGNC 18044
MIM 604437
UniProt Q99624  
 SLC38A3 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for SLC38A3
Molecular Function
    L-histidine transmembrane transporter activity GO:0005290 IBA
    L-histidine transmembrane transporter activity GO:0005290 IDA
    neutral L-amino acid:sodium symporter activity GO:0005295 ISS
    amino acid transmembrane transporter activity GO:0015171 TAS
    L-alanine transmembrane transporter activity GO:0015180 IDA
    L-asparagine transmembrane transporter activity GO:0015182 IBA
    L-asparagine transmembrane transporter activity GO:0015182 IDA
    L-glutamine transmembrane transporter activity GO:0015186 IBA
    L-glutamine transmembrane transporter activity GO:0015186 IDA
    L-glutamine, sodium:proton antiporter activity GO:0140830 ISS
    L-asparagine, sodium:proton antiporter activity GO:0140831 ISS
    L-histidine, sodium:proton antiporter activity GO:0140832 ISS
Biological Process
    amino acid transmembrane transport GO:0003333 IBA
    sodium ion transport GO:0006814 IEA
    amino acid transport GO:0006865 TAS
    asparagine transport GO:0006867 IBA
    asparagine transport GO:0006867 IDA
    glutamine transport GO:0006868 IBA
    glutamine transport GO:0006868 IDA
    female pregnancy GO:0007565 IEA
    glutamine secretion GO:0010585 ISS
    L-alanine transport GO:0015808 IDA
    histidine transport GO:0015817 IBA
    histidine transport GO:0015817 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    cellular response to potassium ion starvation GO:0051365 IEA
    intracellular amino acid homeostasis GO:0080144 ISS
    transport across blood-brain barrier GO:0150104 NAS
    L-histidine transport GO:1902024 ISS
    L-glutamine import across plasma membrane GO:1903803 ISS
    L-histidine import across plasma membrane GO:1903810 ISS
    L-asparagine import across plasma membrane GO:1903811 ISS
    positive regulation of glutamine transport GO:2000487 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    basolateral plasma membrane GO:0016323 IEA
    apical plasma membrane GO:0016324 ISS
 Experiment description of studies that identified SLC38A3 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for SLC38A3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COL6A2 1292
Two-hybrid Homo sapiens
2 TSPAN15 23555
Affinity Capture-MS Homo sapiens
3 NEDD4 4734
Affinity Capture-Western Homo sapiens
4 CACNG6  
Affinity Capture-MS Homo sapiens
5 SCN3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 HMGN1  
Two-hybrid Homo sapiens
7 SETDB1  
Two-hybrid Homo sapiens
View the network image/svg+xml



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