Gene description for TUBGCP5
Gene name tubulin, gamma complex associated protein 5
Gene symbol TUBGCP5
Other names/aliases GCP5
Species Homo sapiens
 Database cross references - TUBGCP5
ExoCarta ExoCarta_114791
Vesiclepedia VP_114791
Entrez Gene 114791
HGNC 18600
MIM 608147
UniProt Q96RT8  
 TUBGCP5 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TUBGCP5
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IDA
    gamma-tubulin binding GO:0043015 IBA
    microtubule minus-end binding GO:0051011 IBA
Biological Process
    mitotic cell cycle GO:0000278 IBA
    microtubule nucleation GO:0007020 IBA
    microtubule nucleation GO:0007020 IDA
    cytoplasmic microtubule organization GO:0031122 IBA
    spindle assembly GO:0051225 IBA
    meiotic cell cycle GO:0051321 IBA
Subcellular Localization
    spindle pole GO:0000922 IEA
    gamma-tubulin complex GO:0000930 IBA
    gamma-tubulin ring complex GO:0000931 IDA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    microtubule GO:0005874 IEA
 Experiment description of studies that identified TUBGCP5 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TUBGCP5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UPK2 7379
Affinity Capture-MS Homo sapiens
2 PRICKLE3  
Affinity Capture-MS Homo sapiens
3 MAGEE1  
Affinity Capture-MS Homo sapiens
4 SYNC  
Affinity Capture-MS Homo sapiens
5 BTRC 8945
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 FBXW11  
Affinity Capture-MS Homo sapiens
7 TMEM132D  
Two-hybrid Homo sapiens
8 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 Tubg1 103733
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
10 MZT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TUBG1 7283
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TUBG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 DAPK2  
Affinity Capture-MS Homo sapiens
14 CD2BP2 10421
Affinity Capture-MS Homo sapiens
15 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TRIM66  
Affinity Capture-MS Homo sapiens
17 SREBF1 6720
Negative Genetic Homo sapiens
18 MZT2B 80097
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 MZT2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TUBGCP3 10426
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 TMEM186  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 RICTOR 253260
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 UBC 7316
Affinity Capture-MS Homo sapiens
24 EGFR 1956
Negative Genetic Homo sapiens
25 TXNDC12 51060
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CLU 1191
Affinity Capture-MS Homo sapiens
27 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
28 DUSP16  
Affinity Capture-MS Homo sapiens
29 ATG4C  
Affinity Capture-MS Homo sapiens
30 TUBGCP4 27229
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 Tubgcp6  
Affinity Capture-MS Mus musculus
32 CDK5RAP2 55755
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
33 ALDH18A1 5832
Affinity Capture-MS Homo sapiens
34 ERF  
Affinity Capture-MS Homo sapiens
35 PTH2R  
Affinity Capture-MS Homo sapiens
36 NEDD1 121441
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 NTRK1 4914
Affinity Capture-MS Homo sapiens
38 NME7 29922
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 Mzt1  
Affinity Capture-MS Mus musculus
40 GPR182  
Affinity Capture-MS Homo sapiens
41 FAM174A 345757
Affinity Capture-MS Homo sapiens
42 SCAF11  
Affinity Capture-MS Homo sapiens
43 HEMK1  
Two-hybrid Homo sapiens
44 PLEKHG1  
Affinity Capture-MS Homo sapiens
45 Mzt2  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
46 Nedd1  
Affinity Capture-MS Mus musculus
47 Tubgcp3  
Affinity Capture-MS Mus musculus
48 CCDC6 8030
Affinity Capture-MS Homo sapiens
49 REPIN1  
Affinity Capture-MS Homo sapiens
50 UBA1 7317
Affinity Capture-MS Homo sapiens
51 DNAJC6  
Affinity Capture-MS Homo sapiens
52 ASPM 259266
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 TUBGCP6 85378
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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