Gene description for SLAMF6
Gene name SLAM family member 6
Gene symbol SLAMF6
Other names/aliases CD352
KALI
KALIb
Ly108
NTB-A
NTBA
SF2000
Species Homo sapiens
 Database cross references - SLAMF6
ExoCarta ExoCarta_114836
Vesiclepedia VP_114836
Entrez Gene 114836
HGNC 21392
MIM 606446
UniProt Q96DU3  
 SLAMF6 identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for SLAMF6
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    immune response GO:0006955 IBA
    positive regulation of type II interferon production GO:0032729 IMP
    positive regulation of interleukin-17 production GO:0032740 IDA
    T cell activation GO:0042110 IBA
    innate immune response GO:0045087 IEA
    positive regulation of natural killer cell mediated cytotoxicity GO:0045954 IDA
    T-helper 17 cell lineage commitment GO:0072540 IDA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLAMF6 in sEVs
1
Experiment ID 79
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for SLAMF6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SELENBP1 8991
Affinity Capture-MS Homo sapiens
2 DUSP14 11072
Affinity Capture-MS Homo sapiens
3 FPGT 8790
Affinity Capture-MS Homo sapiens
4 CLDN19  
Two-hybrid Homo sapiens
5 PTPN11 5781
Affinity Capture-Western Homo sapiens
6 CSNK1D 1453
Affinity Capture-MS Homo sapiens
7 BRICD5  
Two-hybrid Homo sapiens
8 TMBIM6 7009
Two-hybrid Homo sapiens
9 RABAC1 10567
Two-hybrid Homo sapiens
10 SH2D1A 4068
Affinity Capture-Western Homo sapiens
11 DGAT1 8694
Affinity Capture-MS Homo sapiens
12 PTPN6 5777
Affinity Capture-Western Homo sapiens
13 JAGN1 84522
Two-hybrid Homo sapiens
14 TMPPE  
Two-hybrid Homo sapiens
View the network image/svg+xml



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