Gene description for Aldoc
Gene name aldolase C, fructose-bisphosphate
Gene symbol Aldoc
Other names/aliases AI847350
AU040929
Aldo3
Scrg2
Species Mus musculus
 Database cross references - Aldoc
ExoCarta ExoCarta_11676
Vesiclepedia VP_11676
Entrez Gene 11676
UniProt P05063  
 Aldoc identified in sEVs derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Aldoc
Molecular Function
    fructose-bisphosphate aldolase activity GO:0004332 IBA
    fructose-bisphosphate aldolase activity GO:0004332 IDA
    fructose-bisphosphate aldolase activity GO:0004332 ISO
    fructose-bisphosphate aldolase activity GO:0004332 ISS
    fructose-bisphosphate aldolase activity GO:0004332 NAS
    cytoskeletal protein binding GO:0008092 IEA
    cytoskeletal protein binding GO:0008092 ISO
    identical protein binding GO:0042802 ISO
    protein-containing complex binding GO:0044877 ISO
Biological Process
    gluconeogenesis GO:0006094 IDA
    glycolytic process GO:0006096 IBA
    glycolytic process GO:0006096 IEA
    fructose 1,6-bisphosphate metabolic process GO:0030388 IBA
    fructose 1,6-bisphosphate metabolic process GO:0030388 ISO
    fructose 1,6-bisphosphate metabolic process GO:0030388 ISS
    epithelial cell differentiation GO:0030855 IEA
Subcellular Localization
    mitochondrion GO:0005739 HDA
    cytosol GO:0005829 IBA
    axon GO:0030424 ISO
    postsynaptic cytosol GO:0099524 ISO
 Experiment description of studies that identified Aldoc in sEVs
1
Experiment ID 264
MISEV standards
Biophysical techniques
CD63|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-? via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors "Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino"
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Aldoc
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Uqcrh  
Co-fractionation Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Syp  
Co-fractionation Mus musculus
4 MAPT  
Reconstituted Complex Homo sapiens
5 Plp1 18823
Co-fractionation Mus musculus
6 Snap25 20614
Co-fractionation Mus musculus
7 HSD17B10 3028
Affinity Capture-MS Homo sapiens
8 Chaf1a  
Affinity Capture-MS Mus musculus
9 Tia1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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