Gene description for Rhoc
Gene name ras homolog gene family, member C
Gene symbol Rhoc
Other names/aliases AI324259
Arh9
Arhc
Species Mus musculus
 Database cross references - Rhoc
ExoCarta ExoCarta_11853
Vesiclepedia VP_11853
Entrez Gene 11853
UniProt Q62159  
 Rhoc identified in sEVs derived from the following tissue/cell type
Embryonic fibroblasts 18494037    
 Gene ontology annotations for Rhoc
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IEA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 IEA
    protein kinase binding GO:0019901 IBA
Biological Process
    mitotic cytokinesis GO:0000281 IBA
    mitotic cytokinesis GO:0000281 ISO
    mitotic cytokinesis GO:0000281 ISS
    actin filament organization GO:0007015 IBA
    signal transduction GO:0007165 IBA
    small GTPase-mediated signal transduction GO:0007264 IEA
    cell migration GO:0016477 IBA
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of cell migration GO:0030335 ISO
    positive regulation of protein-containing complex assembly GO:0031334 IMP
    regulation of actin cytoskeleton organization GO:0032956 IBA
    apical junction assembly GO:0043297 IDA
    apical junction assembly GO:0043297 ISO
    wound healing, spreading of cells GO:0044319 ISS
    positive regulation of stress fiber assembly GO:0051496 IEA
    positive regulation of stress fiber assembly GO:0051496 ISO
    positive regulation of lipase activity GO:0060193 ISO
    skeletal muscle satellite cell migration GO:1902766 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 ISO
    cleavage furrow GO:0032154 ISO
    cleavage furrow GO:0032154 ISS
    stereocilium GO:0032420 IDA
 Experiment description of studies that identified Rhoc in sEVs
1
Experiment ID 73
MISEV standards
EM
Biophysical techniques
HSP70|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 18494037    
Organism Mus musculus
Experiment description Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes.
Authors "Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, Lim JW, Simpson RJ"
Journal name ELEC
Publication year 2008
Sample Embryonic fibroblasts
Sample name NIH3T3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA]
Western blotting
 Protein-protein interactions for Rhoc
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cyfip1 20430
Affinity Capture-MS Mus musculus
2 Eed  
Affinity Capture-MS Mus musculus
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