Gene description for RN7SK
Gene name RNA, 7SK small nuclear
Gene symbol RN7SK
Other names/aliases 7SK
Species Homo sapiens
 Database cross references - RN7SK
ExoCarta ExoCarta_125050
Vesiclepedia VP_125050
Entrez Gene 125050
HGNC 10037
MIM 606515
 RN7SK identified in sEVs derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for RN7SK
Biological Process
    negative regulation of transcription elongation by RNA polymerase II GO:0034244 IC
Subcellular Localization
    7SK snRNP GO:0120259 IDA
 Experiment description of studies that identified RN7SK in sEVs
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule ncRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for RN7SK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HEXIM1 10614
Affinity Capture-Western Homo sapiens
Affinity Capture-RNA Homo sapiens
Affinity Capture-Western Homo sapiens
2 HNRNPA2B1 3181
Affinity Capture-RNA Homo sapiens
3 HNRNPR 10236
Affinity Capture-RNA Homo sapiens
4 HEXIM2  
Affinity Capture-Western Homo sapiens
5 HMGA1 3159
Protein-RNA Homo sapiens
6 PPM1G 5496
Reconstituted Complex Homo sapiens
7 MEPCE 56257
Biochemical Activity Homo sapiens
8 HNRNPA1 3178
Affinity Capture-RNA Homo sapiens
9 CDK9 1025
Protein-RNA Homo sapiens
Affinity Capture-RNA Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-RNA Homo sapiens
10 DHX9 1660
Affinity Capture-RNA Homo sapiens
View the network image/svg+xml
 Pathways in which RN7SK is involved
No pathways found





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