Gene description for KRT222
Gene name keratin 222, type II
Gene symbol KRT222
Other names/aliases KA21
KRT222P
Species Homo sapiens
 Database cross references - KRT222
ExoCarta ExoCarta_125113
Vesiclepedia VP_125113
Entrez Gene 125113
HGNC 28695
UniProt Q8N1A0  
 KRT222 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for KRT222
Molecular Function
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
Subcellular Localization
    intermediate filament GO:0005882 IEA
 Experiment description of studies that identified KRT222 in sEVs
1
Experiment ID 834
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for KRT222
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATG16L1 55054
Affinity Capture-MS Homo sapiens
2 TXLNA 200081
Affinity Capture-MS Homo sapiens
3 EPB41L1 2036
Affinity Capture-MS Homo sapiens
4 BCAS2 10286
Affinity Capture-MS Homo sapiens
5 RUFY3  
Affinity Capture-MS Homo sapiens
6 EXOC5 10640
Affinity Capture-MS Homo sapiens
7 HSPA6 3310
Two-hybrid Homo sapiens
8 CEP63  
Affinity Capture-MS Homo sapiens
9 PLEC 5339
Affinity Capture-MS Homo sapiens
10 CCDC102A 92922
Affinity Capture-MS Homo sapiens
11 EPB41L3 23136
Affinity Capture-MS Homo sapiens
12 SPAG5 10615
Affinity Capture-MS Homo sapiens
13 HOOK2  
Affinity Capture-MS Homo sapiens
14 EPB41L2 2037
Affinity Capture-MS Homo sapiens
15 RNF208  
Affinity Capture-MS Homo sapiens
16 GNMT 27232
Affinity Capture-MS Homo sapiens
17 EXOC4 60412
Affinity Capture-MS Homo sapiens
18 CEP152  
Affinity Capture-MS Homo sapiens
19 KDM1A 23028
Two-hybrid Homo sapiens
20 PRPF19 27339
Affinity Capture-MS Homo sapiens
21 NEFM 4741
Affinity Capture-MS Homo sapiens
22 EPB41 2035
Affinity Capture-MS Homo sapiens
23 C17orf70  
Affinity Capture-MS Homo sapiens
24 CEP164  
Affinity Capture-MS Homo sapiens
25 EPHA2 1969
Proximity Label-MS Homo sapiens
26 TACC1 6867
Affinity Capture-MS Homo sapiens
27 CROCC 9696
Affinity Capture-MS Homo sapiens
28 HSPA12A 259217
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KRT222 is involved
No pathways found





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