Gene description for Crmp1
Gene name collapsin response mediator protein 1
Gene symbol Crmp1
Other names/aliases CRMP-1
DRP-1
Dpysl1
ULIP-3
Ulip3
Species Mus musculus
 Database cross references - Crmp1
ExoCarta ExoCarta_12933
Vesiclepedia VP_12933
Entrez Gene 12933
UniProt P97427  
 Crmp1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Crmp1
Molecular Function
    dihydropyrimidinase activity GO:0004157 IBA
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016810 IEA
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides GO:0016812 IBA
    filamin binding GO:0031005 ISO
    identical protein binding GO:0042802 ISO
    phosphoprotein binding GO:0051219 IPI
Biological Process
    pyrimidine nucleobase catabolic process GO:0006208 IBA
    negative regulation of neuron projection development GO:0010977 ISO
    semaphorin-plexin signaling pathway GO:0071526 IEP
    semaphorin-plexin signaling pathway GO:0071526 IGI
    regulation of postsynapse assembly GO:0150052 IDA
    regulation of postsynapse assembly GO:0150052 IEP
Subcellular Localization
    cytoplasm GO:0005737 IEA
    centrosome GO:0005813 IEA
    centrosome GO:0005813 ISO
    spindle GO:0005819 IEA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    actin cytoskeleton GO:0015629 IDA
    dendrite GO:0030425 IDA
    growth cone GO:0030426 IDA
    midbody GO:0030496 ISO
    neuronal cell body GO:0043025 IDA
    perikaryon GO:0043204 IEA
    presynapse GO:0098793 IDA
    presynapse GO:0098793 IEP
    postsynapse GO:0098794 IDA
    postsynapse GO:0098794 IEP
 Experiment description of studies that identified Crmp1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Crmp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atxn1  
Proximity Label-MS Mus musculus
2 Cyfip1 20430
Affinity Capture-MS Mus musculus
3 Kctd13  
Affinity Capture-MS Mus musculus
4 Agap2  
Affinity Capture-MS Mus musculus
5 Mcm3ap  
Co-fractionation Mus musculus
6 MTNR1A  
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
7 Huwe1  
Affinity Capture-MS Mus musculus
8 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here