Gene description for Epb4.1l1
Gene name erythrocyte protein band 4.1-like 1
Gene symbol Epb4.1l1
Other names/aliases 4.1N
Epb41l1
NBL1
mKIAA0338
Species Mus musculus
 Database cross references - Epb4.1l1
ExoCarta ExoCarta_13821
Vesiclepedia VP_13821
Entrez Gene 13821
UniProt Q9Z2H5  
 Epb4.1l1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Epb4.1l1
Molecular Function
    actin binding GO:0003779 IEA
    signaling receptor binding GO:0005102 ISO
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
Biological Process
    cortical actin cytoskeleton organization GO:0030866 IEA
    actomyosin structure organization GO:0031032 IBA
    regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane GO:0099145 IDA
    regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane GO:0099145 IEP
    regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane GO:0099145 IMP
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IBA
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    postsynaptic density GO:0014069 IDA
    protein-containing complex GO:0032991 ISO
    synaptic membrane GO:0097060 ISO
 Experiment description of studies that identified Epb4.1l1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Epb4.1l1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nckap1 50884
Affinity Capture-MS Mus musculus
2 Cadm3  
Affinity Capture-Western Mus musculus
3 Cyfip1 20430
Affinity Capture-MS Mus musculus
4 Kctd13  
Affinity Capture-MS Mus musculus
5 Shank3  
Affinity Capture-MS Mus musculus
6 Agap2  
Affinity Capture-MS Mus musculus
7 Fancd2  
Affinity Capture-MS Mus musculus
8 Epb4.1l2 13822
Co-fractionation Mus musculus
9 Dlgap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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