Gene description for Epb4.1l3
Gene name erythrocyte protein band 4.1-like 3
Gene symbol Epb4.1l3
Other names/aliases 4.1B
DAL1P
Dal1
Epb41l3
NBL3
Species Mus musculus
 Database cross references - Epb4.1l3
ExoCarta ExoCarta_13823
Vesiclepedia VP_13823
Entrez Gene 13823
UniProt Q9WV92  
 Epb4.1l3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Epb4.1l3
Molecular Function
    actin binding GO:0003779 IEA
    structural constituent of cytoskeleton GO:0005200 TAS
    protein binding GO:0005515 IPI
    cytoskeletal protein-membrane anchor activity GO:0106006 TAS
Biological Process
    protein localization to paranode region of axon GO:0002175 IMP
    apoptotic process GO:0006915 IEA
    regulation of cell shape GO:0008360 IMP
    cortical cytoskeleton organization GO:0030865 TAS
    cortical actin cytoskeleton organization GO:0030866 IEA
    paranodal junction assembly GO:0030913 IMP
    actomyosin structure organization GO:0031032 IBA
    myelin maintenance GO:0043217 IMP
    neuron projection morphogenesis GO:0048812 IMP
    axon development GO:0061564 IMP
    protein localization to juxtaparanode region of axon GO:0071205 IMP
    protein localization to plasma membrane GO:0072659 IMP
    paranodal junction maintenance GO:1990227 IMP
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IBA
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    cell-cell junction GO:0005911 ISO
    cell-cell junction GO:0005911 ISS
    postsynaptic density GO:0014069 IDA
    cell junction GO:0030054 ISO
    axolemma GO:0030673 IDA
    paranode region of axon GO:0033270 IDA
    paranode region of axon GO:0033270 ISO
    juxtaparanode region of axon GO:0044224 IDA
 Experiment description of studies that identified Epb4.1l3 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Epb4.1l3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nckap1 50884
Affinity Capture-MS Mus musculus
2 Fxr1 14359
Affinity Capture-MS Mus musculus
3 SNCA 6622
Affinity Capture-MS Homo sapiens
4 App 11820
Affinity Capture-MS Mus musculus
5 Cyfip1 20430
Affinity Capture-MS Mus musculus
6 Kctd13  
Affinity Capture-MS Mus musculus
7 Kalrn  
Affinity Capture-MS Mus musculus
8 Dlg4  
Affinity Capture-MS Mus musculus
9 Shank3  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
10 Agap2  
Affinity Capture-MS Mus musculus
11 Huwe1  
Affinity Capture-MS Mus musculus
12 Dlgap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
13 Kcnma1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Epb4.1l3 is involved
PathwayEvidenceSource
Neurexins and neuroligins IEA Reactome
Neuronal System IEA Reactome
Protein-protein interactions at synapses IEA Reactome





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