Gene description for G6pdx
Gene name glucose-6-phosphate dehydrogenase X-linked
Gene symbol G6pdx
Other names/aliases G28A
G6pd
Gpdx
Species Mus musculus
 Database cross references - G6pdx
ExoCarta ExoCarta_14381
Vesiclepedia VP_14381
Entrez Gene 14381
UniProt Q00612  
 G6pdx identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for G6pdx
Molecular Function
    glucose-6-phosphate dehydrogenase activity GO:0004345 IBA
    glucose-6-phosphate dehydrogenase activity GO:0004345 IDA
    glucose-6-phosphate dehydrogenase activity GO:0004345 IMP
    glucose-6-phosphate dehydrogenase activity GO:0004345 ISO
    D-glucose binding GO:0005536 ISO
    carbohydrate binding GO:0030246 ISO
    identical protein binding GO:0042802 IPI
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
    NADP binding GO:0050661 IEA
    NADP binding GO:0050661 ISO
Biological Process
    cytokine production GO:0001816 IMP
    angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001998 IMP
    angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002033 IMP
    glucose metabolic process GO:0006006 IBA
    glucose metabolic process GO:0006006 IEA
    pentose-phosphate shunt GO:0006098 ISO
    cholesterol biosynthetic process GO:0006695 ISO
    NADP metabolic process GO:0006739 ISO
    NADP metabolic process GO:0006739 ISS
    NADPH regeneration GO:0006740 ISO
    NADP biosynthetic process GO:0006741 IDA
    NADP biosynthetic process GO:0006741 IMP
    glutathione metabolic process GO:0006749 IMP
    glutathione metabolic process GO:0006749 ISO
    response to oxidative stress GO:0006979 IMP
    pentose-phosphate shunt, oxidative branch GO:0009051 IBA
    pentose-phosphate shunt, oxidative branch GO:0009051 IMP
    pentose-phosphate shunt, oxidative branch GO:0009051 ISO
    negative regulation of protein glutathionylation GO:0010734 ISO
    pentose biosynthetic process GO:0019322 IDA
    pentose biosynthetic process GO:0019322 IMP
    pentose biosynthetic process GO:0019322 ISO
    interleukin-10 production GO:0032613 IMP
    interleukin-12 production GO:0032615 IMP
    cellular response to oxidative stress GO:0034599 ISO
    regulation of multicellular organism growth GO:0040014 IMP
    erythrocyte maturation GO:0043249 ISO
    regulation of neuron apoptotic process GO:0043523 ISO
    response to ethanol GO:0045471 ISO
    ribose phosphate biosynthetic process GO:0046390 ISO
    erythrocyte development GO:0048821 IMP
    glucose 6-phosphate metabolic process GO:0051156 ISO
    glucose 6-phosphate metabolic process GO:0051156 ISS
    negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 ISO
    positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1904879 ISO
    negative regulation of reactive oxygen species metabolic process GO:2000378 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISO
    cytoplasmic side of plasma membrane GO:0009898 ISO
    membrane GO:0016020 IEA
    centriolar satellite GO:0034451 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified G6pdx in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for G6pdx
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Eif4h 22384
Co-fractionation Mus musculus
2 Tagln  
Affinity Capture-Western Rattus norvegicus
3 Tmem173  
Proximity Label-MS Mus musculus
4 Atxn1  
Affinity Capture-MS Mus musculus
5 Ywhab 54401
Co-fractionation Mus musculus
6 Ubfd1  
Co-fractionation Mus musculus
7 Fancd2  
Affinity Capture-MS Mus musculus
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