Gene description for TTBK2
Gene name	tau tubulin kinase 2
Gene symbol	TTBK2
Other names/aliases	SCA11 TTBK
Species	Homo sapiens
Database cross references - TTBK2
ExoCarta	ExoCarta_146057
Vesiclepedia	VP_146057
Entrez Gene	146057
HGNC	19141
MIM	611695
UniProt	Q6IQ55
TTBK2 identified in sEVs derived from the following tissue/cell type
Squamous carcinoma cells	20124223

Gene ontology annotations for TTBK2

Molecular Function     protein kinase activity GO:0004672 IDA     protein serine/threonine kinase activity GO:0004674 IBA     protein serine/threonine kinase activity GO:0004674 IDA     protein serine/threonine kinase activity GO:0004674 NAS     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IEA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     ribosomal protein S6 kinase activity GO:0004711 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     kinesin binding GO:0019894 IPI     histone H3S10 kinase activity GO:0035175 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     tau protein binding GO:0048156 NAS     tau-protein kinase activity GO:0050321 NAS     tau-protein kinase activity GO:0050321 TAS     microtubule plus-end binding GO:0051010 TAS     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     protein serine kinase activity GO:0106310 IEA     histone H2BS36 kinase activity GO:0140823 IEA     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     histone H2AT120 kinase activity GO:1990244 IEA Biological Process     microtubule cytoskeleton organization GO:0000226 IGI     chromatin remodeling GO:0006338 IEA     negative regulation of microtubule depolymerization GO:0007026 IDA     signal transduction GO:0007165 IBA     smoothened signaling pathway GO:0007224 ISS     peptidyl-serine phosphorylation GO:0018105 IDA     cerebellum development GO:0021549 ISS     cerebellar granular layer development GO:0021681 ISS     cerebellar granule cell precursor tangential migration GO:0021935 ISS     regulation of cell migration GO:0030334 IGI     cilium assembly GO:0060271 IBA     cilium assembly GO:0060271 IMP     cilium assembly GO:0060271 ISS     negative regulation of protein localization to microtubule GO:1902817 IMP     negative regulation of microtubule binding GO:1904527 IDA Subcellular Localization     extracellular space GO:0005615 HDA     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     cytoplasm GO:0005737 IBA     centriole GO:0005814 IDA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     ciliary transition zone GO:0035869 IBA     ciliary transition zone GO:0035869 IDA     ciliary transition zone GO:0035869 ISS     ciliary basal body GO:0036064 IBA     ciliary basal body GO:0036064 ISS