Gene description for RLTPR
Gene name RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
Gene symbol RLTPR
Other names/aliases CARMIL2
CARMIL2b
LRRC16C
Species Homo sapiens
 Database cross references - RLTPR
ExoCarta ExoCarta_146206
Vesiclepedia VP_146206
Entrez Gene 146206
HGNC 27089
MIM 610859
UniProt Q6F5E8  
 RLTPR identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for RLTPR
Molecular Function
    phospholipid binding GO:0005543 IDA
    protein-containing complex binding GO:0044877 IDA
Biological Process
    establishment or maintenance of cell polarity GO:0007163 IDA
    positive regulation of lamellipodium assembly GO:0010592 IDA
    cell migration GO:0016477 IBA
    positive regulation of cell migration GO:0030335 IDA
    regulation of Arp2/3 complex-mediated actin nucleation GO:0034315 IBA
    wound healing, spreading of cells GO:0044319 IDA
    actin filament network formation GO:0051639 IDA
    establishment or maintenance of monopolar cell polarity GO:0061339 IDA
    positive regulation of extracellular matrix disassembly GO:0090091 IDA
    positive regulation of ruffle assembly GO:1900029 IDA
    positive regulation of lamellipodium organization GO:1902745 IDA
    negative regulation of barbed-end actin filament capping GO:2000813 IDA
Subcellular Localization
    ruffle GO:0001726 IDA
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    actin cytoskeleton GO:0015629 IDA
    membrane GO:0016020 HDA
    lamellipodium GO:0030027 IBA
    lamellipodium GO:0030027 IDA
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 NAS
    cell leading edge GO:0031252 IDA
    macropinosome GO:0044354 IDA
    intermediate filament cytoskeleton GO:0045111 IDA
 Experiment description of studies that identified RLTPR in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RLTPR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FOXD3  
Affinity Capture-MS Homo sapiens
2 IQGAP3 128239
Affinity Capture-MS Homo sapiens
3 KRAS 3845
Proximity Label-MS Homo sapiens
4 CAPZB 832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 MED7  
Affinity Capture-MS Homo sapiens
6 CAPZA2 830
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CAPZA1 829
Affinity Capture-MS Homo sapiens
8 PAXIP1  
Affinity Capture-MS Homo sapiens
9 NOTCH1 4851
Affinity Capture-MS Homo sapiens
10 MED24 9862
Affinity Capture-MS Homo sapiens
11 SLC45A1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RLTPR is involved
No pathways found





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