Gene description for CYBA
Gene name	cytochrome b-245, alpha polypeptide
Gene symbol	CYBA
Other names/aliases	p22-PHOX
Species	Homo sapiens
Database cross references - CYBA
ExoCarta	ExoCarta_1535
Vesiclepedia	VP_1535
Entrez Gene	1535
HGNC	2577
MIM	608508
UniProt	P13498
CYBA identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for CYBA

Molecular Function     protein binding GO:0005515 IPI     electron transfer activity GO:0009055 IDA     electron transfer activity GO:0009055 TAS     superoxide-generating NAD(P)H oxidase activity GO:0016175 IMP     SH3 domain binding GO:0017124 IPI     heme binding GO:0020037 IEA     metal ion binding GO:0046872 IEA     protein heterodimerization activity GO:0046982 IPI Biological Process     superoxide metabolic process GO:0006801 IMP     inflammatory response GO:0006954 IMP     smooth muscle hypertrophy GO:0014895 ISS     cytochrome complex assembly GO:0017004 IDA     positive regulation of interleukin-6 production GO:0032755 IDA     positive regulation of tumor necrosis factor production GO:0032760 IDA     positive regulation of toll-like receptor 2 signaling pathway GO:0034137 IDA     superoxide anion generation GO:0042554 IBA     superoxide anion generation GO:0042554 IMP     innate immune response GO:0045087 IMP     innate immune response GO:0045087 ISS     respiratory burst GO:0045730 IMP     respiratory burst GO:0045730 NAS     hydrogen peroxide biosynthetic process GO:0050665 ISS     positive regulation of phagocytosis GO:0050766 IDA     regulation of release of sequestered calcium ion into cytosol GO:0051279 IEA     establishment of localization in cell GO:0051649 IEA     mucus secretion GO:0070254 IEA     positive regulation of mucus secretion GO:0070257 IEA     positive regulation of defense response to bacterium GO:1900426 IDA     positive regulation of reactive oxygen species biosynthetic process GO:1903428 IDA Subcellular Localization     endosome GO:0005768 IEA     endoplasmic reticulum membrane GO:0005789 TAS     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 NAS     plasma membrane GO:0005886 TAS     membrane GO:0016020 HDA     secretory granule GO:0030141 TAS     phagocytic vesicle membrane GO:0030670 TAS     specific granule membrane GO:0035579 TAS     NADPH oxidase complex GO:0043020 IBA     NADPH oxidase complex GO:0043020 IDA     NADPH oxidase complex GO:0043020 IMP     NADPH oxidase complex GO:0043020 NAS     tertiary granule membrane GO:0070821 TAS