Gene description for DAB1
Gene name Dab, reelin signal transducer, homolog 1 (Drosophila)
Gene symbol DAB1
Other names/aliases -
Species Homo sapiens
 Database cross references - DAB1
ExoCarta ExoCarta_1600
Vesiclepedia VP_1600
Entrez Gene 1600
HGNC 2661
MIM 603448
UniProt O75553  
 DAB1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for DAB1
Molecular Function
    protein binding GO:0005515 IPI
    signaling adaptor activity GO:0035591 ISS
Biological Process
    neuron migration GO:0001764 IBA
    negative regulation of cell adhesion GO:0007162 IEA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IEA
    small GTPase-mediated signal transduction GO:0007264 IEA
    axonogenesis GO:0007409 IEA
    adult walking behavior GO:0007628 IEA
    dendrite development GO:0016358 IEA
    ventral spinal cord development GO:0021517 IEA
    cerebellum structural organization GO:0021589 IEA
    hippocampus development GO:0021766 IEA
    cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration GO:0021813 IEA
    layer formation in cerebral cortex GO:0021819 ISS
    radial glia guided migration of Purkinje cell GO:0021942 IEA
    reelin-mediated signaling pathway GO:0038026 ISS
    positive regulation of neuron differentiation GO:0045666 IEA
    negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 IEA
    astrocyte differentiation GO:0048708 IEA
    negative regulation of astrocyte differentiation GO:0048712 IEA
    negative regulation of axonogenesis GO:0050771 IEA
    Golgi localization GO:0051645 IEA
    regulation of synapse maturation GO:0090128 IEA
    lateral motor column neuron migration GO:0097477 IEA
    radial glia-guided pyramidal neuron migration GO:0140650 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 TAS
    intracellular membrane-bounded organelle GO:0043231 IBA
    intracellular membrane-bounded organelle GO:0043231 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified DAB1 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DAB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
2 PAFAH1B1 5048
Reconstituted Complex Homo sapiens
3 ARID5A  
Two-hybrid Homo sapiens
4 SERF2 10169
Two-hybrid Homo sapiens
5 KRTAP19-7  
Two-hybrid Homo sapiens
6 APLP1 333
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 SOCS3 9021
Affinity Capture-Western Homo sapiens
8 ZC3H10  
Two-hybrid Homo sapiens
9 ERBB2 2064
Protein-peptide Homo sapiens
10 RBFOX2 23543
Two-hybrid Homo sapiens
11 USP53 54532
Two-hybrid Homo sapiens
12 RHOXF2  
Two-hybrid Homo sapiens
13 PRR20A  
Two-hybrid Homo sapiens
14 LGALS9C  
Two-hybrid Homo sapiens
15 KRTAP19-5  
Two-hybrid Homo sapiens
16 KRTAP8-1  
Two-hybrid Homo sapiens
17 PIN1 5300
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
18 ERBB3 2065
Protein-peptide Homo sapiens
19 TOLLIP 54472
Two-hybrid Homo sapiens
20 HNRNPLL 92906
Two-hybrid Homo sapiens
21 HYAL3  
Two-hybrid Homo sapiens
22 VLDLR 7436
Two-hybrid Homo sapiens
23 NAF1  
Two-hybrid Homo sapiens
24 SOCS1  
Affinity Capture-Western Homo sapiens
25 BHLHE40  
Two-hybrid Homo sapiens
26 FAM168A  
Two-hybrid Homo sapiens
27 CIART  
Two-hybrid Homo sapiens
28 RBFOX1 54715
Two-hybrid Homo sapiens
29 CDK5 1020
Biochemical Activity Homo sapiens
30 CDK6 1021
Two-hybrid Homo sapiens
31 SOCS7  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
32 TCEA2  
Two-hybrid Homo sapiens
33 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
34 ROR2 4920
Two-hybrid Homo sapiens
35 SMAP2 64744
Two-hybrid Homo sapiens
36 TMTC3 160418
Two-hybrid Homo sapiens
37 ZNF488  
Two-hybrid Homo sapiens
38 LRP1 4035
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
39 SOCS6  
Reconstituted Complex Homo sapiens
40 APLP2 334
Reconstituted Complex Homo sapiens
41 MBNL1 4154
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
42 HMBOX1  
Two-hybrid Homo sapiens
43 SNRPB 6628
Two-hybrid Homo sapiens
44 MAGED1 9500
Two-hybrid Homo sapiens
45 MKRN2 23609
Affinity Capture-RNA Homo sapiens
46 MYO6 4646
Reconstituted Complex Homo sapiens
47 PPIG 9360
Two-hybrid Homo sapiens
48 WDYHV1  
Two-hybrid Homo sapiens
49 ZBTB32  
Two-hybrid Homo sapiens
50 LGALS9B 284194
Two-hybrid Homo sapiens
51 ZCCHC10  
Two-hybrid Homo sapiens
52 LRP2 4036
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
53 CLASRP  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
54 C1orf94  
Two-hybrid Homo sapiens
55 LDLR 3949
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
56 BCL6  
Affinity Capture-MS Homo sapiens
57 SH3KBP1 30011
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
58 MBNL3  
Two-hybrid Homo sapiens
59 SIRPB1 10326
Two-hybrid Homo sapiens
60 TCEANC  
Two-hybrid Homo sapiens
61 INPP5D 3635
Two-hybrid Homo sapiens
62 VENTX  
Two-hybrid Homo sapiens
63 POGZ 23126
Two-hybrid Homo sapiens
64 STRBP 55342
Two-hybrid Homo sapiens
65 LNX1  
Two-hybrid Homo sapiens
66 FAM103A1  
Two-hybrid Homo sapiens
67 DAZAP2  
Two-hybrid Homo sapiens
68 LRP8 7804
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DAB1 is involved
PathwayEvidenceSource
Axon guidance TAS Reactome
Developmental Biology TAS Reactome
Nervous system development TAS Reactome
Reelin signalling pathway TAS Reactome





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