Gene description for Krt1
Gene name keratin 1
Gene symbol Krt1
Other names/aliases Krt-2.1
Krt2-1
Krt86
Species Mus musculus
 Database cross references - Krt1
ExoCarta ExoCarta_16678
Vesiclepedia VP_16678
Entrez Gene 16678
UniProt P04104  
 Krt1 identified in sEVs derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Krt1
Molecular Function
    protein binding GO:0005515 IPI
    carbohydrate binding GO:0030246 IEA
    carbohydrate binding GO:0030246 ISO
    structural constituent of skin epidermis GO:0030280 IBA
    structural constituent of skin epidermis GO:0030280 IEA
    structural constituent of skin epidermis GO:0030280 ISO
    protein heterodimerization activity GO:0046982 ISO
    protein heterodimerization activity GO:0046982 ISS
Biological Process
    complement activation, lectin pathway GO:0001867 IEA
    complement activation, lectin pathway GO:0001867 ISO
    peptide cross-linking GO:0018149 ISO
    keratinization GO:0031424 IBA
    intermediate filament organization GO:0045109 IBA
    negative regulation of inflammatory response GO:0050728 IGI
    negative regulation of inflammatory response GO:0050728 IMP
    protein heterotetramerization GO:0051290 ISO
    protein heterotetramerization GO:0051290 ISS
    establishment of skin barrier GO:0061436 IMP
Subcellular Localization
    cornified envelope GO:0001533 IDA
    cornified envelope GO:0001533 ISO
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    membrane GO:0016020 ISO
    keratin filament GO:0045095 IBA
    keratin filament GO:0045095 IDA
    keratin filament GO:0045095 ISO
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified Krt1 in sEVs
1
Experiment ID 33
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors "Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J"
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Krt1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Invs  
Affinity Capture-MS Mus musculus
2 Nphp3  
Affinity Capture-MS Mus musculus
3 Kctd13  
Affinity Capture-MS Mus musculus
4 Cfap57  
Co-fractionation Mus musculus
5 Nphp4  
Affinity Capture-MS Mus musculus
6 Evpl  
Co-fractionation Mus musculus
7 Eed  
Affinity Capture-MS Mus musculus
8 Thrb  
Affinity Capture-MS Mus musculus
9 Ubash3b  
Co-fractionation Mus musculus
10 Ahi1  
Affinity Capture-MS Mus musculus
11 ITSN1 6453
Two-hybrid Homo sapiens
12 Eps15 13858
Co-fractionation Mus musculus
13 Nphp1  
Affinity Capture-MS Mus musculus
14 Inppl1  
Co-fractionation Mus musculus
15 Krt79  
Co-fractionation Mus musculus
16 Mks1  
Affinity Capture-MS Mus musculus
17 Iqcb1  
Affinity Capture-MS Mus musculus
18 Nanog  
Affinity Capture-MS Mus musculus
19 Fancd2  
Affinity Capture-MS Mus musculus
20 Sbsn  
Co-fractionation Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here