Gene description for MIER3
Gene name mesoderm induction early response 1, family member 3
Gene symbol MIER3
Other names/aliases -
Species Homo sapiens
 Database cross references - MIER3
ExoCarta ExoCarta_166968
Vesiclepedia VP_166968
Entrez Gene 166968
HGNC 26678
UniProt Q7Z3K6  
 MIER3 identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for MIER3
Molecular Function
    transcription corepressor activity GO:0003714 IBA
    histone deacetylase activity GO:0004407 IDA
    protein binding GO:0005515 IPI
    histone deacetylase binding GO:0042826 IBA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified MIER3 in sEVs
1
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MIER3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 H2AFZ 3015
Affinity Capture-MS Homo sapiens
2 H2AFJ 55766
Affinity Capture-MS Homo sapiens
3 HIST1H2BG 8339
Affinity Capture-MS Homo sapiens
4 WIZ 58525
Affinity Capture-MS Homo sapiens
5 HIST1H2BE 8344
Affinity Capture-MS Homo sapiens
6 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
7 MICAL1 64780
Affinity Capture-MS Homo sapiens
8 STK16 8576
Two-hybrid Homo sapiens
9 HDAC2 3066
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 BAHD1  
Affinity Capture-MS Homo sapiens
11 HIST3H2BB 128312
Affinity Capture-MS Homo sapiens
12 C16orf87 388272
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 HIST1H2BA 255626
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 HIST1H2AE 3012
Affinity Capture-MS Homo sapiens
16 HIST1H2BI 8346
Affinity Capture-MS Homo sapiens
17 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
18 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
19 MCRS1  
Two-hybrid Homo sapiens
20 H2AFX 3014
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 IGSF21  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MIER3 is involved
No pathways found





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