Gene description for DNTT
Gene name DNA nucleotidylexotransferase
Gene symbol DNTT
Other names/aliases TDT
Species Homo sapiens
 Database cross references - DNTT
ExoCarta ExoCarta_1791
Vesiclepedia VP_1791
Entrez Gene 1791
HGNC 2983
MIM 187410
UniProt P04053  
 DNTT identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for DNTT
Molecular Function
    DNA binding GO:0003677 IEA
    DNA-directed DNA polymerase activity GO:0003887 IEA
    DNA nucleotidylexotransferase activity GO:0003912 IBA
    DNA nucleotidylexotransferase activity GO:0003912 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    DNA metabolic process GO:0006259 IDA
    double-strand break repair via nonhomologous end joining GO:0006303 IBA
    DNA modification GO:0006304 IEA
    response to ATP GO:0033198 IEA
    DNA biosynthetic process GO:0071897 IEA
Subcellular Localization
    euchromatin GO:0000791 IEA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    nuclear matrix GO:0016363 IEA
 Experiment description of studies that identified DNTT in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DNTT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNTTIP1 116092
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
2 XRCC6 2547
Affinity Capture-Western Homo sapiens
3 PCNA 5111
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
4 ABTB2 25841
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
5 CUL3 8452
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 PRPF19 27339
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
7 TCF4  
Two-hybrid Homo sapiens
8 DNTTIP2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
9 REL 5966
Two-hybrid Homo sapiens
10 MEI4  
Two-hybrid Homo sapiens
11 APOA1 335
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DNTT is involved
No pathways found





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