Gene description for Mapre2
Gene name microtubule-associated protein, RP/EB family, member 2
Gene symbol Mapre2
Other names/aliases AI314113
C820009F03Rik
D18Abb1e
EB1
EB2
RP1
Species Mus musculus
 Database cross references - Mapre2
ExoCarta ExoCarta_212307
Vesiclepedia VP_212307
Entrez Gene 212307
UniProt Q8R001  
 Mapre2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Mapre2
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 ISO
    protein kinase binding GO:0019901 IPI
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    microtubule plus-end binding GO:0051010 IBA
    microtubule plus-end binding GO:0051010 IDA
Biological Process
    regulation of microtubule polymerization or depolymerization GO:0031110 IBA
    positive regulation of ARF protein signal transduction GO:0032014 IMP
    protein localization to microtubule GO:0035372 IBA
    positive regulation of GTPase activity GO:0043547 IMP
    spindle assembly GO:0051225 IBA
    cell division GO:0051301 IEA
    positive regulation of keratinocyte migration GO:0051549 IMP
    positive regulation of focal adhesion disassembly GO:0120183 IMP
Subcellular Localization
    cytoplasm GO:0005737 IEA
    microtubule organizing center GO:0005815 IBA
    microtubule GO:0005874 IEA
    cytoplasmic microtubule GO:0005881 IBA
    focal adhesion GO:0005925 IDA
    focal adhesion GO:0005925 ISO
    microtubule cytoskeleton GO:0015630 ISO
    microtubule plus-end GO:0035371 IBA
    spindle midzone GO:0051233 IBA
 Experiment description of studies that identified Mapre2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Mapre2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRPF6 24148
Two-hybrid Homo sapiens
2 GTSE1 51512
Two-hybrid Homo sapiens
3 Foxp3  
Affinity Capture-MS Mus musculus
4 Apc  
Co-localization Mus musculus
5 Mapt  
Affinity Capture-MS Mus musculus
6 LLPH  
Two-hybrid Homo sapiens
7 YTHDF1 54915
Two-hybrid Homo sapiens
8 Ubc  
Reconstituted Complex Mus musculus
View the network image/svg+xml
 Pathways in which Mapre2 is involved
No pathways found





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