Gene description for SDK1
Gene name sidekick cell adhesion molecule 1
Gene symbol SDK1
Other names/aliases -
Species Homo sapiens
 Database cross references - SDK1
ExoCarta ExoCarta_221935
Vesiclepedia VP_221935
Entrez Gene 221935
HGNC 19307
MIM 607216
UniProt Q7Z5N4  
 SDK1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SDK1
Molecular Function
    identical protein binding GO:0042802 ISS
Biological Process
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IBA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 ISS
    synapse assembly GO:0007416 IBA
    synapse assembly GO:0007416 ISS
    retina layer formation GO:0010842 ISS
    behavioral response to cocaine GO:0048148 IEA
    regulation of dendritic spine development GO:0060998 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    synapse GO:0045202 IBA
    synapse GO:0045202 ISS
 Experiment description of studies that identified SDK1 in sEVs
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SDK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RYK 6259
Affinity Capture-MS Homo sapiens
2 MLLT4 4301
Proximity Label-MS Homo sapiens
3 LGALS7 3963
Affinity Capture-MS Homo sapiens
4 LGALS3 3958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 RHOB 388
Proximity Label-MS Homo sapiens
6 KCNE3  
Affinity Capture-MS Homo sapiens
7 KRAS 3845
Proximity Label-MS Homo sapiens
8 LGALS8 3964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 LGALS1 3956
Affinity Capture-MS Homo sapiens
10 MKRN2 23609
Affinity Capture-RNA Homo sapiens
11 UBC 7316
Reconstituted Complex Homo sapiens
12 TMX1 81542
Affinity Capture-MS Homo sapiens
13 LNX1  
Two-hybrid Homo sapiens
14 PRPF40A 55660
Two-hybrid Homo sapiens
15 MYC  
Affinity Capture-MS Homo sapiens
16 GJA1 2697
Proximity Label-MS Homo sapiens
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